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• W3038971566 abstract "Severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug rash with eosinophilia and systemic symptoms (DRESS), are idiosyncratic and unpredictable drug hypersensitivity reactions with high mortality rate from 10% to over 30% that cause a major burden on the healthcare system. Recent pharmacogenomic studies have revealed strong associations between SCAR and the genes encoding human leukocyte antigens (HLAs) or drug-metabolizing enzymes. Some of pharmacogenetic markers have been successfully applied in clinical practice to prevent patients from SCAR, such as HLA-B*1502 and HLA-A*3101 for new users of carbamazepine, HLA-B*5801 for allopurinol and HLA-B*5701 for abacavir. This article aims to update the current knowledge in the field of pharmacogenomics on drug hypersensitivities or SCAR and the implementation in clinical practice." @default.
• W3038971566 created "2020-07-10" @default.
• W3038971566 creator A5014258731 @default.
• W3038971566 creator A5043638381 @default.
• W3038971566 creator A5057475035 @default.
• W3038971566 creator A5067205844 @default.
• W3038971566 creator A5074346604 @default.
• W3038971566 date "2020-07-02" @default.
• W3038971566 modified "2023-10-12" @default.
• W3038971566 title "Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions" @default.
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