FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3038975603> ?p ?o ?g. }

• W3038975603 abstract "The aim was to investigate the long-term prophylactic efficacy, drug retention and safety of low-dose sulfamethoxazole-trimethoprim (SMX/TMP) prophylaxis against Pneumocystis pneumonia (PCP).Adult patients with rheumatic diseases receiving prednisolone ≥0.6 mg/kg/day were randomized into the single-strength group (SS; SMX/TMP 400/80 mg daily), the half-strength group (HS; 200/40 mg daily) or the escalation group (ES; starting at 40/8 mg and increasing incrementally to 200/40 mg daily) and treated for 24 weeks, then observed for 52 weeks. The primary endpoint, the PCP non-incidence rate (non-IR) at week 24, has been reported previously. The secondary endpoints were the PCP non-IR at week 52, treatment discontinuation rate and adverse events.Fifty-eight, 59 and 55 patients in the SS, HS and ES, respectively, received SMX/TMP. PCP did not develop in any of the patients by week 52. The estimated PCP non-IR in patients receiving SMX/TMP 200/40 mg daily (HS and ES) was 96.8-100%. Throughout the 52-week observation period, the overall discontinuation rate was significantly lower in HS than in SS (22.7 vs 47.2%, P = 0.004). The discontinuation rates attributable to adverse events were significantly lower in HS (19.1%, P = 0.007) and ES (20.3%, P = 0.007) than in SS (41.8%). The IRs of adverse events requiring SMX/TMP dose reduction before week 52 differed among the three groups, with a significantly higher IR in SS than in HS or ES (P = 0.007).SMX/TMP 200/40 mg had a high PCP prevention rate and was superior to SMX/TMP 400/80 mg in terms of drug retention and safety.University Hospital Medical Information Network Clinical Trials Registry, UMIN000007727." @default.
• W3038975603 created "2020-07-10" @default.
• W3038975603 creator A5006135689 @default.
• W3038975603 creator A5010908061 @default.
• W3038975603 creator A5019029901 @default.
• W3038975603 creator A5020106035 @default.
• W3038975603 creator A5022742352 @default.
• W3038975603 creator A5024926145 @default.
• W3038975603 creator A5027120492 @default.
• W3038975603 creator A5029149453 @default.
• W3038975603 creator A5030963270 @default.
• W3038975603 creator A5033302978 @default.
• W3038975603 creator A5034587395 @default.
• W3038975603 creator A5041976581 @default.
• W3038975603 creator A5043341144 @default.
• W3038975603 creator A5044262898 @default.
• W3038975603 creator A5048198478 @default.
• W3038975603 creator A5050880728 @default.
• W3038975603 creator A5051390394 @default.
• W3038975603 creator A5057897107 @default.
• W3038975603 creator A5060555424 @default.
• W3038975603 creator A5064918848 @default.
• W3038975603 creator A5071289620 @default.
• W3038975603 creator A5071663801 @default.
• W3038975603 creator A5074265016 @default.
• W3038975603 creator A5081181665 @default.
• W3038975603 creator A5083044716 @default.
• W3038975603 creator A5089912304 @default.
• W3038975603 date "2020-01-01" @default.
• W3038975603 modified "2023-10-12" @default.
• W3038975603 title "An open-label, randomized controlled trial of sulfamethoxazole–trimethoprim for Pneumocystis prophylaxis: results of 52-week follow-up" @default.
• W3038975603 cites W1495954281 @default.
• W3038975603 cites W1963733265 @default.
• W3038975603 cites W1968696159 @default.
• W3038975603 cites W1969452774 @default.
• W3038975603 cites W1994062747 @default.
• W3038975603 cites W2071257400 @default.
• W3038975603 cites W2095621848 @default.
• W3038975603 cites W2112908451 @default.
• W3038975603 cites W2125803267 @default.
• W3038975603 cites W2129246503 @default.
• W3038975603 cites W2137591261 @default.
• W3038975603 cites W2176976630 @default.
• W3038975603 cites W2384346244 @default.
• W3038975603 cites W2488421632 @default.
• W3038975603 cites W2578004401 @default.
• W3038975603 cites W2607650379 @default.
• W3038975603 cites W2766715376 @default.
• W3038975603 cites W2928402904 @default.
• W3038975603 cites W4235171022 @default.
• W3038975603 cites W4245401508 @default.
• W3038975603 cites W4250846836 @default.
• W3038975603 cites W4256642426 @default.
• W3038975603 cites W4320300927 @default.
• W3038975603 cites W4321429245 @default.
• W3038975603 doi "https://doi.org/10.1093/rap/rkaa029" @default.
• W3038975603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7585401" @default.
• W3038975603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33134810" @default.
• W3038975603 hasPublicationYear "2020" @default.
• W3038975603 type Work @default.
• W3038975603 sameAs 3038975603 @default.
• W3038975603 citedByCount "6" @default.
• W3038975603 countsByYear W30389756032021 @default.
• W3038975603 countsByYear W30389756032022 @default.
• W3038975603 crossrefType "journal-article" @default.
• W3038975603 hasAuthorship W3038975603A5006135689 @default.
• W3038975603 hasAuthorship W3038975603A5010908061 @default.
• W3038975603 hasAuthorship W3038975603A5019029901 @default.
• W3038975603 hasAuthorship W3038975603A5020106035 @default.
• W3038975603 hasAuthorship W3038975603A5022742352 @default.
• W3038975603 hasAuthorship W3038975603A5024926145 @default.
• W3038975603 hasAuthorship W3038975603A5027120492 @default.
• W3038975603 hasAuthorship W3038975603A5029149453 @default.
• W3038975603 hasAuthorship W3038975603A5030963270 @default.
• W3038975603 hasAuthorship W3038975603A5033302978 @default.
• W3038975603 hasAuthorship W3038975603A5034587395 @default.
• W3038975603 hasAuthorship W3038975603A5041976581 @default.
• W3038975603 hasAuthorship W3038975603A5043341144 @default.
• W3038975603 hasAuthorship W3038975603A5044262898 @default.
• W3038975603 hasAuthorship W3038975603A5048198478 @default.
• W3038975603 hasAuthorship W3038975603A5050880728 @default.
• W3038975603 hasAuthorship W3038975603A5051390394 @default.
• W3038975603 hasAuthorship W3038975603A5057897107 @default.
• W3038975603 hasAuthorship W3038975603A5060555424 @default.
• W3038975603 hasAuthorship W3038975603A5064918848 @default.
• W3038975603 hasAuthorship W3038975603A5071289620 @default.
• W3038975603 hasAuthorship W3038975603A5071663801 @default.
• W3038975603 hasAuthorship W3038975603A5074265016 @default.
• W3038975603 hasAuthorship W3038975603A5081181665 @default.
• W3038975603 hasAuthorship W3038975603A5083044716 @default.
• W3038975603 hasAuthorship W3038975603A5089912304 @default.
• W3038975603 hasBestOaLocation W30389756031 @default.
• W3038975603 hasConcept C120665830 @default.
• W3038975603 hasConcept C121332964 @default.
• W3038975603 hasConcept C126322002 @default.
• W3038975603 hasConcept C141071460 @default.
• W3038975603 hasConcept C162156334 @default.
• W3038975603 hasConcept C168563851 @default.
• W3038975603 hasConcept C197934379 @default.
• W3038975603 hasConcept C203092338 @default.

• next