FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039009612> ?p ?o ?g. }

• W3039009612 endingPage "1084" @default.
• W3039009612 startingPage "1074" @default.
• W3039009612 abstract "Intervertebral disc degeneration (IDD) is a condition involving disruption of the bone tissue distribution. Nucleus pulposus mesenchymal stem cells (NPMSCs) and Sirtuin 1 (SIRT1) play important roles in bone diseases, therefore the aim of the present study was to evaluate the roles of SIRT1 and NPMSCs in IDD. First, NPMSCs were harvested from patients with IDD. Then, the NPMSCs were treated with a SIRT activator, and monocyte chemoattractant protein 1 (MCP1) and chemokine receptor 2 (CCR2) inhibitors. Indices related to NPMSC growth, proliferation, differentiation and apoptosis were measured. Subsequently, IDD rat models were established and were transfected with NPMSCs overexpressing SIRT1. NPMSC apoptosis and cartilage differentiation were detected in the rat IDD model. SIRT1 expression was found to be decreased, and the expression of MCP1 and CCR2 increased in NPMSCs of patients with IDD. The upregulation of SIRT1 and the downregulation of the MCP1/CCR2 axis promoted cartilage differentiation and reduced the number of apoptotic NPMSCs. Furthermore, MCP1 reversed the progression of the cartilage differentiation of NPMSCs and the inhibition of NPMSC apoptosis induced by SIRT1 overexpression. Moreover, the transplantation of rat NPMSCs overexpressing SIRT1 relieved IDD in rats. Therefore, SIRT1 overexpression improved cartilage differentiation and reduced the apoptosis of NPMSCs by inactivating the MCP1/CCR2 axis, thus attenuating IDD in rats." @default.
• W3039009612 created "2020-07-10" @default.
• W3039009612 creator A5043405694 @default.
• W3039009612 creator A5046659695 @default.
• W3039009612 creator A5065382355 @default.
• W3039009612 creator A5067295958 @default.
• W3039009612 creator A5077235314 @default.
• W3039009612 date "2020-07-03" @default.
• W3039009612 modified "2023-10-16" @default.
• W3039009612 title "Activation of SIRT1 promotes cartilage differentiation and reduces apoptosis of nucleus pulposus mesenchymal stem cells via the MCP1/CCR2 axis in subjects with intervertebral disc degeneration" @default.
• W3039009612 cites W178666107 @default.
• W3039009612 cites W1995045618 @default.
• W3039009612 cites W2006736938 @default.
• W3039009612 cites W2030437338 @default.
• W3039009612 cites W2197102422 @default.
• W3039009612 cites W2288482594 @default.
• W3039009612 cites W2338692354 @default.
• W3039009612 cites W2481034678 @default.
• W3039009612 cites W2538795414 @default.
• W3039009612 cites W2545116789 @default.
• W3039009612 cites W2559958272 @default.
• W3039009612 cites W2591259489 @default.
• W3039009612 cites W2591635052 @default.
• W3039009612 cites W2595806588 @default.
• W3039009612 cites W2613556062 @default.
• W3039009612 cites W2617435689 @default.
• W3039009612 cites W2746671913 @default.
• W3039009612 cites W2755966035 @default.
• W3039009612 cites W2762017125 @default.
• W3039009612 cites W2775188988 @default.
• W3039009612 cites W2809899663 @default.
• W3039009612 cites W2810124170 @default.
• W3039009612 cites W2811287043 @default.
• W3039009612 cites W2884101530 @default.
• W3039009612 cites W2885613245 @default.
• W3039009612 cites W2892426195 @default.
• W3039009612 cites W2894561292 @default.
• W3039009612 cites W2896077768 @default.
• W3039009612 cites W2901834597 @default.
• W3039009612 cites W2911230790 @default.
• W3039009612 cites W2913105578 @default.
• W3039009612 cites W2914515734 @default.
• W3039009612 cites W2936021205 @default.
• W3039009612 cites W2943719115 @default.
• W3039009612 cites W2946171504 @default.
• W3039009612 cites W2972702332 @default.
• W3039009612 cites W2984409972 @default.
• W3039009612 doi "https://doi.org/10.3892/ijmm.2020.4668" @default.
• W3039009612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7387093" @default.
• W3039009612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32705163" @default.
• W3039009612 hasPublicationYear "2020" @default.
• W3039009612 type Work @default.
• W3039009612 sameAs 3039009612 @default.
• W3039009612 citedByCount "5" @default.
• W3039009612 countsByYear W30390096122021 @default.
• W3039009612 countsByYear W30390096122022 @default.
• W3039009612 countsByYear W30390096122023 @default.
• W3039009612 crossrefType "journal-article" @default.
• W3039009612 hasAuthorship W3039009612A5043405694 @default.
• W3039009612 hasAuthorship W3039009612A5046659695 @default.
• W3039009612 hasAuthorship W3039009612A5065382355 @default.
• W3039009612 hasAuthorship W3039009612A5067295958 @default.
• W3039009612 hasAuthorship W3039009612A5077235314 @default.
• W3039009612 hasBestOaLocation W30390096121 @default.
• W3039009612 hasConcept C104317684 @default.
• W3039009612 hasConcept C105702510 @default.
• W3039009612 hasConcept C127561419 @default.
• W3039009612 hasConcept C12823836 @default.
• W3039009612 hasConcept C13373296 @default.
• W3039009612 hasConcept C185592680 @default.
• W3039009612 hasConcept C190283241 @default.
• W3039009612 hasConcept C198826908 @default.
• W3039009612 hasConcept C203014093 @default.
• W3039009612 hasConcept C206615009 @default.
• W3039009612 hasConcept C2776536020 @default.
• W3039009612 hasConcept C2776914184 @default.
• W3039009612 hasConcept C2777755357 @default.
• W3039009612 hasConcept C2780550940 @default.
• W3039009612 hasConcept C502942594 @default.
• W3039009612 hasConcept C55493867 @default.
• W3039009612 hasConcept C86803240 @default.
• W3039009612 hasConcept C95444343 @default.
• W3039009612 hasConceptScore W3039009612C104317684 @default.
• W3039009612 hasConceptScore W3039009612C105702510 @default.
• W3039009612 hasConceptScore W3039009612C127561419 @default.
• W3039009612 hasConceptScore W3039009612C12823836 @default.
• W3039009612 hasConceptScore W3039009612C13373296 @default.
• W3039009612 hasConceptScore W3039009612C185592680 @default.
• W3039009612 hasConceptScore W3039009612C190283241 @default.
• W3039009612 hasConceptScore W3039009612C198826908 @default.
• W3039009612 hasConceptScore W3039009612C203014093 @default.
• W3039009612 hasConceptScore W3039009612C206615009 @default.
• W3039009612 hasConceptScore W3039009612C2776536020 @default.
• W3039009612 hasConceptScore W3039009612C2776914184 @default.
• W3039009612 hasConceptScore W3039009612C2777755357 @default.
• W3039009612 hasConceptScore W3039009612C2780550940 @default.
• W3039009612 hasConceptScore W3039009612C502942594 @default.
• W3039009612 hasConceptScore W3039009612C55493867 @default.

• next