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- W3039060043 abstract "Human papillomavirus (HPV) is a DNA virus from Papillomavirus family, and is one of the mostwidely reported sexual infection, which is not only related to ano-genital malignancies, but also associated with head and neck cancers, with chronic periodontitis being one of the risk factor for the same.Chronic periodontitis leads to loss of tissue structures of and around periodontium and is clinicallydetectable in the form of periodontal pocket and loss of alveolar bone. A variety of other systemicdiseases have also been found to be linked to chronic periodontitis, such as cardiovascular diseases,respiratory diseases, etc., and recent data show that it is also related to malignancies of oral cavity.Junctional epithelium of periodontal pocket helps HPV to survive by facilitating the cellular functions to grow and hence, acts as a reservoir for the virus. Porphyromonas gingivalis, a Gram-negativeanaerobic bacteria and HPV interacts both directly and indirectly in a series of complex reactionsand as a result of some inflammatory reactions, this association further leads to commencement andprogression of head and neck squamous cell carcinoma or oral squamous cell carcinoma. This articlereviews the pathophysiology of oral human papillomavirus infection and its role in head and neckcancers, with chronic periodontitis as one of the causative factors" @default.
- W3039060043 created "2020-07-10" @default.
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- W3039060043 date "2020-01-01" @default.
- W3039060043 modified "2023-10-14" @default.
- W3039060043 title "Periodontitis as a reservoir of human papillomavirus in the causation of oral squamous cell carcinoma: a review" @default.
- W3039060043 doi "https://doi.org/10.5114/hivar.2020.96430" @default.
- W3039060043 hasPublicationYear "2020" @default.
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