Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039069304> ?p ?o ?g. }
- W3039069304 endingPage "1765" @default.
- W3039069304 startingPage "1765" @default.
- W3039069304 abstract "Tumor cells can hijack chemokine networks to support tumor progression. In this context, the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5) axis is gaining increasing attention, since abnormal expression and activity of CCL5 and its receptor CCR5 have been found in hematological malignancies and solid tumors. Numerous preclinical in vitro and in vivo studies have shown a key role of the CCL5/CCR5 axis in cancer, and thus provided the rationale for clinical trials using the repurposed drug maraviroc, a CCR5 antagonist used to treat HIV/AIDS. This review summarizes current knowledge on the role of the CCL5/CCR5 axis in cancer. First, it describes the involvement of the CCL5/CCR5 axis in cancer progression, including autocrine and paracrine tumor growth, ECM (extracellular matrix) remodeling and migration, cancer stem cell expansion, DNA damage repair, metabolic reprogramming, and angiogenesis. Then, it focuses on individual hematological and solid tumors in which CCL5 and CCR5 have been studied preclinically. Finally, it discusses clinical trials of strategies to counteract the CCL5/CCR5 axis in different cancers using maraviroc or therapeutic monoclonal antibodies." @default.
- W3039069304 created "2020-07-10" @default.
- W3039069304 creator A5006278471 @default.
- W3039069304 creator A5016581593 @default.
- W3039069304 creator A5020517759 @default.
- W3039069304 date "2020-07-02" @default.
- W3039069304 modified "2023-10-14" @default.
- W3039069304 title "The CCL5/CCR5 Axis in Cancer Progression" @default.
- W3039069304 cites W1107917109 @default.
- W3039069304 cites W1506568005 @default.
- W3039069304 cites W1512694675 @default.
- W3039069304 cites W1532258142 @default.
- W3039069304 cites W1547160344 @default.
- W3039069304 cites W1565568215 @default.
- W3039069304 cites W1860605136 @default.
- W3039069304 cites W1886545902 @default.
- W3039069304 cites W1909018478 @default.
- W3039069304 cites W194396632 @default.
- W3039069304 cites W1968028469 @default.
- W3039069304 cites W1968101362 @default.
- W3039069304 cites W1971422550 @default.
- W3039069304 cites W1972319813 @default.
- W3039069304 cites W1976978160 @default.
- W3039069304 cites W1982673084 @default.
- W3039069304 cites W1983261726 @default.
- W3039069304 cites W1983891041 @default.
- W3039069304 cites W1990703790 @default.
- W3039069304 cites W1991060586 @default.
- W3039069304 cites W1992254343 @default.
- W3039069304 cites W1995213909 @default.
- W3039069304 cites W1995557161 @default.
- W3039069304 cites W1998310721 @default.
- W3039069304 cites W1998392042 @default.
- W3039069304 cites W1999648081 @default.
- W3039069304 cites W2001399830 @default.
- W3039069304 cites W2001868807 @default.
- W3039069304 cites W2002349915 @default.
- W3039069304 cites W2003409252 @default.
- W3039069304 cites W2003562985 @default.
- W3039069304 cites W2004007490 @default.
- W3039069304 cites W2006778528 @default.
- W3039069304 cites W2007936467 @default.
- W3039069304 cites W2010375889 @default.
- W3039069304 cites W2011797653 @default.
- W3039069304 cites W2017570593 @default.
- W3039069304 cites W2022292514 @default.
- W3039069304 cites W2025591832 @default.
- W3039069304 cites W2027535817 @default.
- W3039069304 cites W2029525850 @default.
- W3039069304 cites W2032434507 @default.
- W3039069304 cites W2040016252 @default.
- W3039069304 cites W2040048742 @default.
- W3039069304 cites W2040241698 @default.
- W3039069304 cites W2043398751 @default.
- W3039069304 cites W2047594721 @default.
- W3039069304 cites W2058188568 @default.
- W3039069304 cites W2059695760 @default.
- W3039069304 cites W2063220206 @default.
- W3039069304 cites W2064873657 @default.
- W3039069304 cites W2064964116 @default.
- W3039069304 cites W2069986720 @default.
- W3039069304 cites W2070771684 @default.
- W3039069304 cites W2073244735 @default.
- W3039069304 cites W2073428139 @default.
- W3039069304 cites W2075561524 @default.
- W3039069304 cites W2075966373 @default.
- W3039069304 cites W2079317778 @default.
- W3039069304 cites W2086354032 @default.
- W3039069304 cites W2086423745 @default.
- W3039069304 cites W2089275178 @default.
- W3039069304 cites W2090464229 @default.
- W3039069304 cites W2094903014 @default.
- W3039069304 cites W2095098163 @default.
- W3039069304 cites W2097216067 @default.
- W3039069304 cites W2098913562 @default.
- W3039069304 cites W2102054577 @default.
- W3039069304 cites W2103560672 @default.
- W3039069304 cites W2109889966 @default.
- W3039069304 cites W2115096627 @default.
- W3039069304 cites W2116455112 @default.
- W3039069304 cites W2116511683 @default.
- W3039069304 cites W2120100742 @default.
- W3039069304 cites W2120159810 @default.
- W3039069304 cites W2124373181 @default.
- W3039069304 cites W2127107746 @default.
- W3039069304 cites W2127909824 @default.
- W3039069304 cites W2135558815 @default.
- W3039069304 cites W2139171427 @default.
- W3039069304 cites W2140299974 @default.
- W3039069304 cites W2141815918 @default.
- W3039069304 cites W2142583019 @default.
- W3039069304 cites W2146590054 @default.
- W3039069304 cites W2147820545 @default.
- W3039069304 cites W2153657104 @default.
- W3039069304 cites W2155061120 @default.
- W3039069304 cites W2157235421 @default.
- W3039069304 cites W2162060250 @default.
- W3039069304 cites W2163807830 @default.