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- W3039080821 abstract "NeurodevelopmentEven in adults, neurons in the brain can regenerate. Progenitor neural stem cells (NSCs) in adult rodents are found in the subventricular zone of the lateral ventricles and the hippocampus. Radial-glia–like NSCs in the hippocampus, as their name suggests, have a tree-like structure. They send thin terminal processes from the subgranular zone into an area called the inner molecular layer. When activated by exercise, for example, NSCs transform into new neurons, but this requires bloodborne components. Licht et al. show that NSC processes form direct membrane-to-membrane contact with endothelial cells in specialized areas where the basement membrane is interrupted by zones of vesicular activity. In this way, NSCs circumvent the blood-brain barrier to access molecules that normally cannot penetrate the brain.eLife 9 , e52134 (2020)." @default.
- W3039080821 created "2020-07-10" @default.
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- W3039080821 date "2020-07-02" @default.
- W3039080821 modified "2023-10-18" @default.
- W3039080821 title "Bloodborne privilege for stem cells" @default.
- W3039080821 doi "https://doi.org/10.1126/science.369.6499.46-a" @default.
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