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- W3039093919 abstract "Aim: Antidrug antibody (ADA) assessment may be challenged in studies that involve the administration of high doses of biotherapeutics and/or with long half-lives. In such cases, ADA assays with optimized drug tolerance are desired. Material & Methods: We evaluated the use of MgCl 2 to develop high ionic strength dissociation assays in two investigational examples (bridging enzyme-linked immunosorbent ADA assays) to attain high drug tolerance while maintaining best possible structural integrity of ADAs. Results: Both ADA-bridging assays treated with MgCl 2 showed improved drug tolerance and higher signal-to-blank values compared with overnight incubation or acid treatment. Conclusion: The use of MgCl 2 treatment in ADA-bridging assays provides a sensitive, drug tolerant and easy-to-use alternative in cases where acid dissociation is not possible or unwanted." @default.
- W3039093919 created "2020-07-10" @default.
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- W3039093919 date "2020-06-30" @default.
- W3039093919 modified "2023-10-16" @default.
- W3039093919 title "High ionic strength dissociation assay (HISDA) for high drug tolerant immunogenicity testing" @default.
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- W3039093919 doi "https://doi.org/10.4155/bio-2020-0138" @default.
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