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- W3039094805 abstract "Solid tumors frequently contain cells that are heterogeneous in the copy number of DNA loci. This fact implies the existence of genetic instability, which may be associated with disease aggressiveness. Accurate measurement of this phenomenon requires analysis of intact nuclei within their natural tissue context. We perform these measurements by preparing >30μm thick tissue sections, labeling them with fluorescent labels for total DNA and for specific DNA loci using fluorescence in situ hybridization (FISH) which retain the transparency of the tissue and acquiring 3D images of the tissue using confocal microscopy (figure 1). In this study, we combined automated 3D image analysis (IA) algorithms for segmenting individual nuclei based on the total DNA stain1 and for segmenting the punctuate FISH signals of DNA loci. This enables us to efficiently enumerate the copy number of specific DNA loci in individual cells and as a function of the cell's location in the tissue." @default.
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- W3039094805 date "1999-08-01" @default.
- W3039094805 modified "2023-10-18" @default.
- W3039094805 title "3d Confocal Microscopy and Image Analysis for Measurement of Genetic Instability" @default.
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- W3039094805 doi "https://doi.org/10.1017/s1431927600018432" @default.
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