FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039123050> ?p ?o ?g. }

• W3039123050 endingPage "4791" @default.
• W3039123050 startingPage "4791" @default.
• W3039123050 abstract "Clinical and preclinical studies indicate that zinc (Zn) is an essential factor in the development and treatment of major depressive disorder (MDD). Conventional monoamine-based antidepressants mobilize zinc in the blood and brain of depressed patients as well as rodents. N-methyl-D-aspartate acid receptor (NMDAR) antagonists exhibit antidepressant-like activity. However, not much is known about the antidepressant efficacy of NMDAR antagonists in zinc-deficient (ZnD) animals. We evaluated the antidepressant-like activity of two NMDAR antagonists (ketamine; global NMDAR antagonist and Ro 25-6981 (Ro); selective antagonist of the GluN2B NMDAR subunit) in ZnD rats using the forced swim test (FST) and sucrose intake test (SIT). A single dose of either Ro 25-6981 or ketamine normalized depressive-like behaviors in ZnD rats; however, Ro was effective in both tests, while ketamine was only effective in the FST. Additionally, we investigated the mechanism of antidepressant action of Ro at the molecular (analysis of protein expression by Western blotting) and anatomical (density of dendritic spines by Golgi Cox-staining) levels. ZnD rats exhibited decreased phosphorylation of the p70S6K protein, and enhanced density of dendritic spines in the prefrontal cortex (PFC) compared to control rats. The antidepressant-like activity of Ro was associated with the increased phosphorylation of p70S6K and ERK in the PFC. In summary, single doses of the NMDAR antagonists ketamine and Ro exhibited antidepressant-like activity in the ZnD animal model of depression. Animals were only deprived of Zn for 4 weeks and the biochemical effects of Zn deprivation and Ro were investigated in the PFC and hippocampus. The shorter duration of dietary Zn restriction may be a limitation of the study. However, future studies with longer durations of dietary Zn restriction, as well as the investigation of multiple brain structures, are encouraged as a supplement to this study." @default.
• W3039123050 created "2020-07-10" @default.
• W3039123050 creator A5028212666 @default.
• W3039123050 creator A5034328473 @default.
• W3039123050 creator A5044015773 @default.
• W3039123050 creator A5045678056 @default.
• W3039123050 creator A5087036644 @default.
• W3039123050 date "2020-07-06" @default.
• W3039123050 modified "2023-09-26" @default.
• W3039123050 title "Ketamine and Ro 25-6981 Reverse Behavioral Abnormalities in Rats Subjected to Dietary Zinc Restriction" @default.
• W3039123050 cites W1136508987 @default.
• W3039123050 cites W1746596066 @default.
• W3039123050 cites W1971979491 @default.
• W3039123050 cites W1976392245 @default.
• W3039123050 cites W1978130328 @default.
• W3039123050 cites W1990697514 @default.
• W3039123050 cites W2004320420 @default.
• W3039123050 cites W2008310959 @default.
• W3039123050 cites W2023081218 @default.
• W3039123050 cites W2033676408 @default.
• W3039123050 cites W2034154165 @default.
• W3039123050 cites W2035015498 @default.
• W3039123050 cites W2036609223 @default.
• W3039123050 cites W2039178606 @default.
• W3039123050 cites W2040122143 @default.
• W3039123050 cites W2042783249 @default.
• W3039123050 cites W2045076279 @default.
• W3039123050 cites W2045413945 @default.
• W3039123050 cites W2048431959 @default.
• W3039123050 cites W2051045531 @default.
• W3039123050 cites W2053913132 @default.
• W3039123050 cites W2059585701 @default.
• W3039123050 cites W2061943108 @default.
• W3039123050 cites W2074243201 @default.
• W3039123050 cites W2076054524 @default.
• W3039123050 cites W2080797234 @default.
• W3039123050 cites W2084475427 @default.
• W3039123050 cites W2086726646 @default.
• W3039123050 cites W2089351762 @default.
• W3039123050 cites W2093932385 @default.
• W3039123050 cites W2097951289 @default.
• W3039123050 cites W2103255996 @default.
• W3039123050 cites W2109334244 @default.
• W3039123050 cites W2121208444 @default.
• W3039123050 cites W2130139152 @default.
• W3039123050 cites W2144269887 @default.
• W3039123050 cites W2153347959 @default.
• W3039123050 cites W2179322633 @default.
• W3039123050 cites W2327348530 @default.
• W3039123050 cites W2410876341 @default.
• W3039123050 cites W2510927228 @default.
• W3039123050 cites W2618399463 @default.
• W3039123050 cites W2744283556 @default.
• W3039123050 cites W2779386549 @default.
• W3039123050 cites W2796940952 @default.
• W3039123050 cites W2890611676 @default.
• W3039123050 cites W2897256412 @default.
• W3039123050 cites W2931112790 @default.
• W3039123050 cites W2936542920 @default.
• W3039123050 cites W2950045154 @default.
• W3039123050 cites W2963643921 @default.
• W3039123050 cites W2986257172 @default.
• W3039123050 cites W2987474448 @default.
• W3039123050 cites W3003830815 @default.
• W3039123050 doi "https://doi.org/10.3390/ijms21134791" @default.
• W3039123050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7369754" @default.
• W3039123050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32640759" @default.
• W3039123050 hasPublicationYear "2020" @default.
• W3039123050 type Work @default.
• W3039123050 sameAs 3039123050 @default.
• W3039123050 citedByCount "4" @default.
• W3039123050 countsByYear W30391230502021 @default.
• W3039123050 countsByYear W30391230502022 @default.
• W3039123050 crossrefType "journal-article" @default.
• W3039123050 hasAuthorship W3039123050A5028212666 @default.
• W3039123050 hasAuthorship W3039123050A5034328473 @default.
• W3039123050 hasAuthorship W3039123050A5044015773 @default.
• W3039123050 hasAuthorship W3039123050A5045678056 @default.
• W3039123050 hasAuthorship W3039123050A5087036644 @default.
• W3039123050 hasBestOaLocation W30391230501 @default.
• W3039123050 hasConcept C126322002 @default.
• W3039123050 hasConcept C134018914 @default.
• W3039123050 hasConcept C136569192 @default.
• W3039123050 hasConcept C169760540 @default.
• W3039123050 hasConcept C170493617 @default.
• W3039123050 hasConcept C185592680 @default.
• W3039123050 hasConcept C2776885963 @default.
• W3039123050 hasConcept C2779177272 @default.
• W3039123050 hasConcept C2780795376 @default.
• W3039123050 hasConcept C2781161787 @default.
• W3039123050 hasConcept C61174792 @default.
• W3039123050 hasConcept C67018056 @default.
• W3039123050 hasConcept C71924100 @default.
• W3039123050 hasConcept C86803240 @default.
• W3039123050 hasConcept C98274493 @default.
• W3039123050 hasConceptScore W3039123050C126322002 @default.
• W3039123050 hasConceptScore W3039123050C134018914 @default.
• W3039123050 hasConceptScore W3039123050C136569192 @default.

• next