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- W3039131097 abstract "After 300 million years of evolution, the first land‐living mammals reentered the marine environment some 50 million years ago. The driving forces for this dramatic lifestyle change are still a matter of discussion but the struggle for food resources and the opportunity to escape predators probably contributed. Reentering the oceans requires metabolic adaption putting evolutionary pressure on a number of genes. To explore whether eicosanoid signaling has been part of this adaptive response, we first explored whether the genomes of marine mammals involve functional genes encoding for key enzymes of eicosanoid biosynthesis. Cyclooxygenase (COX) and lipoxygenase (ALOX) genes are present in the genome of all marine mammals tested. Interestingly, ALOX12B, which has been implicated in skin development of land‐living mammals, is lacking in whales and dolphins and genes encoding for its sister enzyme (ALOXE3) involve premature stop codons and/or frameshifting point mutations, which interrupt the open reading frames. ALOX15 orthologs have been detected in all marine mammals, and the recombinant enzymes exhibit similar catalytic properties as those of land‐living species. All marine mammals express arachidonic acid 12‐lipoxygenating ALOX15 orthologs, and these data are consistent with the Evolutionary Hypothesis of ALOX15 specificity. These enzymes exhibit membrane oxygenase activity and introduction of big amino acids at the triad positions altered the reaction specificity in favor of arachidonic acid 15‐lipoxygenation. Thus, the ALOX15 orthologs of marine mammals follow the Triad concept explaining their catalytic specificity." @default.
- W3039131097 created "2020-07-10" @default.
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- W3039131097 creator A5083619672 @default.
- W3039131097 date "2020-07-18" @default.
- W3039131097 modified "2023-10-15" @default.
- W3039131097 title "Eicosanoid biosynthesis in marine mammals" @default.
- W3039131097 cites W1490851239 @default.
- W3039131097 cites W1514733921 @default.
- W3039131097 cites W1540646729 @default.
- W3039131097 cites W1542997309 @default.
- W3039131097 cites W1549591697 @default.
- W3039131097 cites W1562016580 @default.
- W3039131097 cites W1562310953 @default.
- W3039131097 cites W1627304319 @default.
- W3039131097 cites W1973784980 @default.
- W3039131097 cites W1974961079 @default.
- W3039131097 cites W1975207791 @default.
- W3039131097 cites W1976321027 @default.
- W3039131097 cites W1978603467 @default.
- W3039131097 cites W1978704058 @default.
- W3039131097 cites W1979107796 @default.
- W3039131097 cites W1985941719 @default.
- W3039131097 cites W1987090231 @default.
- W3039131097 cites W1992794298 @default.
- W3039131097 cites W1994616470 @default.
- W3039131097 cites W1995663832 @default.
- W3039131097 cites W1996649892 @default.
- W3039131097 cites W2002754258 @default.
- W3039131097 cites W2004006318 @default.
- W3039131097 cites W2004704496 @default.
- W3039131097 cites W2008654319 @default.
- W3039131097 cites W2010355242 @default.
- W3039131097 cites W2011710650 @default.
- W3039131097 cites W2013571533 @default.
- W3039131097 cites W2014818104 @default.
- W3039131097 cites W2015899470 @default.
- W3039131097 cites W2016239417 @default.
- W3039131097 cites W2025122196 @default.
- W3039131097 cites W2028705982 @default.
- W3039131097 cites W2029387641 @default.
- W3039131097 cites W2032763669 @default.
- W3039131097 cites W2037567873 @default.
- W3039131097 cites W2041860844 @default.
- W3039131097 cites W2043952276 @default.
- W3039131097 cites W2050568232 @default.
- W3039131097 cites W2052624151 @default.
- W3039131097 cites W2055023776 @default.
- W3039131097 cites W2058823227 @default.
- W3039131097 cites W2065377708 @default.
- W3039131097 cites W2072000048 @default.
- W3039131097 cites W2072537434 @default.
- W3039131097 cites W2077694076 @default.
- W3039131097 cites W2081521523 @default.
- W3039131097 cites W2082973874 @default.
- W3039131097 cites W2084852947 @default.
- W3039131097 cites W2085067780 @default.
- W3039131097 cites W2096648902 @default.
- W3039131097 cites W2100073813 @default.
- W3039131097 cites W2106114908 @default.
- W3039131097 cites W2108207007 @default.
- W3039131097 cites W2114374331 @default.
- W3039131097 cites W2116591510 @default.
- W3039131097 cites W2125376440 @default.
- W3039131097 cites W2127161627 @default.
- W3039131097 cites W2129280925 @default.
- W3039131097 cites W2134966116 @default.
- W3039131097 cites W2147276198 @default.
- W3039131097 cites W2149233326 @default.
- W3039131097 cites W2156973347 @default.
- W3039131097 cites W2184888523 @default.
- W3039131097 cites W2190162356 @default.
- W3039131097 cites W2300552860 @default.
- W3039131097 cites W2316741846 @default.
- W3039131097 cites W2327673880 @default.
- W3039131097 cites W2473287368 @default.
- W3039131097 cites W2483488371 @default.
- W3039131097 cites W2504045125 @default.
- W3039131097 cites W2508163039 @default.
- W3039131097 cites W2577013444 @default.
- W3039131097 cites W2793586505 @default.
- W3039131097 cites W2890899921 @default.
- W3039131097 cites W2892316903 @default.
- W3039131097 cites W2905449420 @default.
- W3039131097 cites W2905586714 @default.
- W3039131097 cites W2907899175 @default.
- W3039131097 cites W2927894892 @default.
- W3039131097 cites W2982410994 @default.
- W3039131097 doi "https://doi.org/10.1111/febs.15469" @default.
- W3039131097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32627384" @default.
- W3039131097 hasPublicationYear "2020" @default.
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