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- W3039190222 abstract "Background: Brain-derived neurotrophic factor (BDNF), recognized to be involved in differentiation andproliferation of specialized cell such as endothelial cell and osteoblast cell.Aim of the Study: The study was designed to identify the effect of exogenous BDNF on development ofjaw and on neural marker expression.Materials and Method: Twenty pregnant rats,ten injected (I.M) with normal saline,other ten injected(I.M) with 0.1 ml of BDNF that received three doses at intervals (0,7,14 day of gestation period).Embryosat 16th and 18th intra-uterine life were used for histological and immunohistochemical evaluation for thedevelopment of prenatal jaw .Results: Illustrate an enhancement of bone development during proceeding embryonic periods for bothstudy groups .Moreover, the experimental group shows a high significant difference in the mean of bone cellcount at the period 18th day in comparisum to 16th day IUL,and in comparisum to control at 18th day IUL.Results show positive expression of neuronal marker by proliferating nerve cells in control and experimentalgroups with significant difference.Conclusion: The study suggest that BDNF contributes to promoting the differentiation of bone cells andenhancement of bone formation by increasing expression of neuron marker" @default.
- W3039190222 created "2020-07-10" @default.
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- W3039190222 date "2020-02-01" @default.
- W3039190222 modified "2023-09-23" @default.
- W3039190222 title "Neurological And Non Neurological Role of Brain-Derived Neurotrophic Factor (BDNF) in Developing Jaw" @default.
- W3039190222 doi "https://doi.org/10.37506/v11/i2/2020/ijphrd/195050" @default.
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