FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039200746> ?p ?o ?g. }

• W3039200746 abstract "Abstract DNA replication in eukaryotic cells initiates from chromosomal locations, called replication origins, that bind the Origin Recognition Complex (ORC) prior to S phase. Origin establishment is guided by well-defined DNA sequence motifs in Saccharomyces cerevisiae and some other budding yeasts, but most eukaryotes lack sequence-specific origins. At present, the mechanistic and evolutionary reasons for this difference are unclear. A 3.9 Å structure of S. cerevisiae ORC-Cdc6-Cdt1-Mcm2-7 (OCCM) bound to origin DNA revealed, among other things, that a loop within Orc2 inserts into a DNA minor groove and an α-helix within Orc4 inserts into a DNA major groove 1 . We show that this Orc4 α-helix mediates the sequence-specificity of origins in S. cerevisiae . Specifically, mutations were identified within this α-helix that alter the sequence-dependent activity of individual origins as well as change global genomic origin firing patterns. This was accomplished using a massively parallel origin selection assay analyzed using a custom mutual-information-based modeling approach and a separate analysis of whole-genome replication profiling and statistics. Interestingly, the sequence specificity of DNA replication initiation, as mediated by the Orc4 α-helix, has evolved in close conjunction with the gain of ORC-Sir4-mediated gene silencing and the loss of RNA interference." @default.
• W3039200746 created "2020-07-10" @default.
• W3039200746 creator A5011415232 @default.
• W3039200746 creator A5026134956 @default.
• W3039200746 creator A5045530101 @default.
• W3039200746 creator A5054594638 @default.
• W3039200746 creator A5063449249 @default.
• W3039200746 creator A5069407651 @default.
• W3039200746 creator A5071437258 @default.
• W3039200746 creator A5076746607 @default.
• W3039200746 creator A5088677145 @default.
• W3039200746 date "2020-07-04" @default.
• W3039200746 modified "2023-09-26" @default.
• W3039200746 title "Evolution of DNA Replication Origin Specification and Gene Silencing Mechanisms" @default.
• W3039200746 cites W1499220571 @default.
• W3039200746 cites W1962652794 @default.
• W3039200746 cites W1974126704 @default.
• W3039200746 cites W1978617734 @default.
• W3039200746 cites W1982453928 @default.
• W3039200746 cites W2003885532 @default.
• W3039200746 cites W2015635728 @default.
• W3039200746 cites W2019772640 @default.
• W3039200746 cites W2023870674 @default.
• W3039200746 cites W2028873833 @default.
• W3039200746 cites W2037061918 @default.
• W3039200746 cites W2044279758 @default.
• W3039200746 cites W2045178475 @default.
• W3039200746 cites W2059594509 @default.
• W3039200746 cites W2060599714 @default.
• W3039200746 cites W2061449183 @default.
• W3039200746 cites W2095146606 @default.
• W3039200746 cites W2101013700 @default.
• W3039200746 cites W2102473929 @default.
• W3039200746 cites W2134421533 @default.
• W3039200746 cites W2141919058 @default.
• W3039200746 cites W2147208232 @default.
• W3039200746 cites W2149676146 @default.
• W3039200746 cites W2150308082 @default.
• W3039200746 cites W2152731657 @default.
• W3039200746 cites W2154467428 @default.
• W3039200746 cites W2155802675 @default.
• W3039200746 cites W2159933659 @default.
• W3039200746 cites W2166459599 @default.
• W3039200746 cites W2171460421 @default.
• W3039200746 cites W2194086801 @default.
• W3039200746 cites W2255538802 @default.
• W3039200746 cites W2263529005 @default.
• W3039200746 cites W2316990088 @default.
• W3039200746 cites W2327727661 @default.
• W3039200746 cites W2473838984 @default.
• W3039200746 cites W2497129027 @default.
• W3039200746 cites W2517008357 @default.
• W3039200746 cites W2518735686 @default.
• W3039200746 cites W2588958371 @default.
• W3039200746 cites W2606660232 @default.
• W3039200746 cites W2743954317 @default.
• W3039200746 cites W2912756262 @default.
• W3039200746 cites W2944831967 @default.
• W3039200746 cites W2977607727 @default.
• W3039200746 cites W2995997429 @default.
• W3039200746 doi "https://doi.org/10.1101/2020.07.04.187286" @default.
• W3039200746 hasPublicationYear "2020" @default.
• W3039200746 type Work @default.
• W3039200746 sameAs 3039200746 @default.
• W3039200746 citedByCount "3" @default.
• W3039200746 countsByYear W30392007462020 @default.
• W3039200746 crossrefType "posted-content" @default.
• W3039200746 hasAuthorship W3039200746A5011415232 @default.
• W3039200746 hasAuthorship W3039200746A5026134956 @default.
• W3039200746 hasAuthorship W3039200746A5045530101 @default.
• W3039200746 hasAuthorship W3039200746A5054594638 @default.
• W3039200746 hasAuthorship W3039200746A5063449249 @default.
• W3039200746 hasAuthorship W3039200746A5069407651 @default.
• W3039200746 hasAuthorship W3039200746A5071437258 @default.
• W3039200746 hasAuthorship W3039200746A5076746607 @default.
• W3039200746 hasAuthorship W3039200746A5088677145 @default.
• W3039200746 hasBestOaLocation W30392007461 @default.
• W3039200746 hasConcept C104690221 @default.
• W3039200746 hasConcept C151158763 @default.
• W3039200746 hasConcept C175193931 @default.
• W3039200746 hasConcept C54355233 @default.
• W3039200746 hasConcept C552990157 @default.
• W3039200746 hasConcept C58337764 @default.
• W3039200746 hasConcept C70721500 @default.
• W3039200746 hasConcept C73573662 @default.
• W3039200746 hasConcept C86803240 @default.
• W3039200746 hasConcept C98086919 @default.
• W3039200746 hasConceptScore W3039200746C104690221 @default.
• W3039200746 hasConceptScore W3039200746C151158763 @default.
• W3039200746 hasConceptScore W3039200746C175193931 @default.
• W3039200746 hasConceptScore W3039200746C54355233 @default.
• W3039200746 hasConceptScore W3039200746C552990157 @default.
• W3039200746 hasConceptScore W3039200746C58337764 @default.
• W3039200746 hasConceptScore W3039200746C70721500 @default.
• W3039200746 hasConceptScore W3039200746C73573662 @default.
• W3039200746 hasConceptScore W3039200746C86803240 @default.
• W3039200746 hasConceptScore W3039200746C98086919 @default.
• W3039200746 hasLocation W30392007461 @default.
• W3039200746 hasLocation W30392007462 @default.
• W3039200746 hasLocation W30392007463 @default.

• next