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• W3039221818 startingPage "305" @default.
• W3039221818 abstract "The recent outbreak of 2019 coronavirus disease (COVID-19), caused by a novel coronavirus, has now spread quickly worldwide. Like the severe acute respiratory syndrome coronavirus (SARS-CoV), this novel type of coronavirus, SARS-CoV-2, has been demonstrated to utilize angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. There is a growing body of reports indicating that COVID-19 patients, especially those in severe condition, exhibit neurological symptoms, thus supporting the possibility that SARS-CoV-2 could infect and damage neurons within the central nervous system in humans. Using human pluripotent stem cells-derived neurons, here we show the expression of ACE2 in human neurons via immunocytochemistry. From this perspective, we elaborate on the idea that the neuro-invasive potential of SARS-CoV-2 should be considered as a possible contributory factor, as well as a therapeutic target, for the severe respiratory symptoms in critical COVID-19 cases." @default.
• W3039221818 created "2020-07-10" @default.
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• W3039221818 date "2020-07-04" @default.
• W3039221818 modified "2023-10-14" @default.
• W3039221818 title "Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus" @default.
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• W3039221818 doi "https://doi.org/10.1007/s10571-020-00915-1" @default.
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