FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039222561> ?p ?o ?g. }

• W3039222561 endingPage "1600" @default.
• W3039222561 startingPage "1600" @default.
• W3039222561 abstract "The ubiquitin E3 ligase RNF220 and its co-factor ZC4H2 are required for multiple neural developmental processes through different targets, including spinal cord patterning and the development of the cerebellum and the locus coeruleus. Here, we explored the effects of loss of ZC4H2 and RNF220 on the proliferation and differentiation of neural stem cells (NSCs) derived from mouse embryonic cortex. We showed that loss of either ZC4H2 or RNF220 inhibits the proliferation and promotes the differentiation abilities of NSCs in vitro. RNA-Seq profiling revealed 132 and 433 differentially expressed genes in the ZC4H2−/− and RNF220−/− NSCs, compared to wild type (WT) NSCs, respectively. Specifically, Cend1, a key regulator of cell cycle exit and differentiation of neuronal precursors, was found to be upregulated in both ZC4H2−/− and RNF220−/− NSCs at the mRNA and protein levels. The targets of Cend1, such as CyclinD1, Notch1 and Hes1, were downregulated both in ZC4H2−/− and RNF220−/− NSCs, whereas p53 and p21 were elevated. ZC4H2−/− and RNF220−/− NSCs showed G0/G1 phase arrest compared to WT NSCs in cell cycle analysis. These results suggested that ZC4H2 and RNF220 are likely involved in the regulation of neural stem cell proliferation and differentiation through Cend1." @default.
• W3039222561 created "2020-07-10" @default.
• W3039222561 creator A5015441271 @default.
• W3039222561 creator A5018670313 @default.
• W3039222561 creator A5025364983 @default.
• W3039222561 creator A5036204556 @default.
• W3039222561 creator A5057665531 @default.
• W3039222561 creator A5073326801 @default.
• W3039222561 creator A5082517606 @default.
• W3039222561 date "2020-07-01" @default.
• W3039222561 modified "2023-10-09" @default.
• W3039222561 title "Loss of ZC4H2 and RNF220 Inhibits Neural Stem Cell Proliferation and Promotes Neuronal Differentiation" @default.
• W3039222561 cites W1224329310 @default.
• W3039222561 cites W1930450407 @default.
• W3039222561 cites W1963619510 @default.
• W3039222561 cites W1990736719 @default.
• W3039222561 cites W2019520565 @default.
• W3039222561 cites W2033822105 @default.
• W3039222561 cites W2035618305 @default.
• W3039222561 cites W2043821791 @default.
• W3039222561 cites W2055950005 @default.
• W3039222561 cites W2063896137 @default.
• W3039222561 cites W2079356804 @default.
• W3039222561 cites W2083072084 @default.
• W3039222561 cites W2084318043 @default.
• W3039222561 cites W2110905563 @default.
• W3039222561 cites W2112055300 @default.
• W3039222561 cites W2143129177 @default.
• W3039222561 cites W2143730501 @default.
• W3039222561 cites W2146111983 @default.
• W3039222561 cites W2155892454 @default.
• W3039222561 cites W2162015825 @default.
• W3039222561 cites W2169456326 @default.
• W3039222561 cites W2179438025 @default.
• W3039222561 cites W2345071900 @default.
• W3039222561 cites W2598916786 @default.
• W3039222561 cites W2768184598 @default.
• W3039222561 cites W2804121313 @default.
• W3039222561 cites W2890955041 @default.
• W3039222561 cites W2952177710 @default.
• W3039222561 cites W2957148050 @default.
• W3039222561 cites W2963466130 @default.
• W3039222561 cites W3007616814 @default.
• W3039222561 cites W3022424576 @default.
• W3039222561 cites W3023427661 @default.
• W3039222561 doi "https://doi.org/10.3390/cells9071600" @default.
• W3039222561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7408363" @default.
• W3039222561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32630355" @default.
• W3039222561 hasPublicationYear "2020" @default.
• W3039222561 type Work @default.
• W3039222561 sameAs 3039222561 @default.
• W3039222561 citedByCount "8" @default.
• W3039222561 countsByYear W30392225612021 @default.
• W3039222561 countsByYear W30392225612022 @default.
• W3039222561 countsByYear W30392225612023 @default.
• W3039222561 crossrefType "journal-article" @default.
• W3039222561 hasAuthorship W3039222561A5015441271 @default.
• W3039222561 hasAuthorship W3039222561A5018670313 @default.
• W3039222561 hasAuthorship W3039222561A5025364983 @default.
• W3039222561 hasAuthorship W3039222561A5036204556 @default.
• W3039222561 hasAuthorship W3039222561A5057665531 @default.
• W3039222561 hasAuthorship W3039222561A5073326801 @default.
• W3039222561 hasAuthorship W3039222561A5082517606 @default.
• W3039222561 hasBestOaLocation W30392225611 @default.
• W3039222561 hasConcept C104317684 @default.
• W3039222561 hasConcept C136834591 @default.
• W3039222561 hasConcept C145103041 @default.
• W3039222561 hasConcept C148738053 @default.
• W3039222561 hasConcept C1491633281 @default.
• W3039222561 hasConcept C161879069 @default.
• W3039222561 hasConcept C2777933648 @default.
• W3039222561 hasConcept C2780283210 @default.
• W3039222561 hasConcept C28328180 @default.
• W3039222561 hasConcept C29537977 @default.
• W3039222561 hasConcept C4746552 @default.
• W3039222561 hasConcept C54355233 @default.
• W3039222561 hasConcept C62112901 @default.
• W3039222561 hasConcept C62478195 @default.
• W3039222561 hasConcept C86803240 @default.
• W3039222561 hasConcept C95444343 @default.
• W3039222561 hasConceptScore W3039222561C104317684 @default.
• W3039222561 hasConceptScore W3039222561C136834591 @default.
• W3039222561 hasConceptScore W3039222561C145103041 @default.
• W3039222561 hasConceptScore W3039222561C148738053 @default.
• W3039222561 hasConceptScore W3039222561C1491633281 @default.
• W3039222561 hasConceptScore W3039222561C161879069 @default.
• W3039222561 hasConceptScore W3039222561C2777933648 @default.
• W3039222561 hasConceptScore W3039222561C2780283210 @default.
• W3039222561 hasConceptScore W3039222561C28328180 @default.
• W3039222561 hasConceptScore W3039222561C29537977 @default.
• W3039222561 hasConceptScore W3039222561C4746552 @default.
• W3039222561 hasConceptScore W3039222561C54355233 @default.
• W3039222561 hasConceptScore W3039222561C62112901 @default.
• W3039222561 hasConceptScore W3039222561C62478195 @default.
• W3039222561 hasConceptScore W3039222561C86803240 @default.
• W3039222561 hasConceptScore W3039222561C95444343 @default.
• W3039222561 hasIssue "7" @default.
• W3039222561 hasLocation W30392225611 @default.

• next