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• W3039224043 abstract "The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of STING is phosphorylated, leading to induction of type I interferons (IFNs). Additionally, evolutionary conserved responses such as autophagy also occur downstream of STING, but their relative importance during in vivo infections remains unclear. Here we report that mice harboring a serine 365-to-alanine (S365A) mutation in STING are unexpectedly resistant to Herpes Simplex Virus (HSV)-1, despite lacking STING-induced type I IFN responses. By contrast, resistance to HSV-1 is abolished in mice lacking the STING CTT, suggesting that the STING CTT initiates protective responses against HSV-1, independently of type I IFNs. Interestingly, we find that STING-induced autophagy is a CTT- and TBK1-dependent but IRF3-independent process that is conserved in the STING S365A mice. Thus, interferon-independent functions of STING mediate STING-dependent antiviral responses in vivo." @default.
• W3039224043 created "2020-07-10" @default.
• W3039224043 creator A5000724016 @default.
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• W3039224043 date "2020-07-07" @default.
• W3039224043 modified "2023-10-15" @default.
• W3039224043 title "Interferon-independent STING signaling promotes resistance to HSV-1 in vivo" @default.
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• W3039224043 doi "https://doi.org/10.1038/s41467-020-17156-x" @default.
• W3039224043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7341812" @default.
• W3039224043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32636381" @default.
• W3039224043 hasPublicationYear "2020" @default.
• W3039224043 type Work @default.

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