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• W3039225135 endingPage "116715" @default.
• W3039225135 startingPage "116715" @default.
• W3039225135 abstract "Tumor-associated macrophages (TAMs) with an M2-like phenotype have been linked to immunosuppression and resistance to chemotherapies of cancer, thus targeting TAMs has been an attractive therapeutic strategy to cancer immunotherapy. We have reported that the β-D-(1→6) glucan (AAMP-A70) isolated from Amillariella Mellea could promote macrophage activation. The present study showed that the β-1,6-glucan could promote the transformation of M2-like macrophages to M1-like phenotype and inhibit the viability of colon cancer cells in vitro and in vivo. On a cellular mechanistic level, the β-1,6-glucan reset tumor-promoting M2-like macrophages to tumor-inhibiting M1-like phenotype via increasing the phosphorylation of Akt/NF-κB and MAPK. Further, TLR2 was identified as the receptor of β-1,6-glucan in the transformation effect. In addition, a very similar β-1,6-glucan with side chains of β-Glc or α-Galρ which was purified from Lentinus edodes showed same activities with those from Amillariella Mellea. Our findings shed light on the action mode of β-1,6-glucan in cancer immunotherapy." @default.
• W3039225135 created "2020-07-10" @default.
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• W3039225135 date "2020-11-01" @default.
• W3039225135 modified "2023-10-06" @default.
• W3039225135 title "Beta-1,6 glucan converts tumor-associated macrophages into an M1-like phenotype" @default.
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• W3039225135 doi "https://doi.org/10.1016/j.carbpol.2020.116715" @default.
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