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• W3039230007 endingPage "107827" @default.
• W3039230007 startingPage "107827" @default.
• W3039230007 abstract "The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in the PD-1 pathway exhibit impaired CD8+ T cell memory following acute influenza infection, including reduced virus-specific CD8+ T cell numbers and compromised recall responses. PD-1 blockade during priming leads to similar differences early post-infection but without the defect in memory formation, suggesting that timing and/or duration of PD-1 blockade could be tailored to modulate host responses. Our studies reveal a role for PD-1 as an integrator of CD8+ T cell signals that promotes CD8+ T cell memory formation and suggest PD-1 continues to fine-tune CD8+ T cells after they migrate into non-lymphoid tissues. These findings have important implications for PD-1-based immunotherapy, in which PD-1 inhibition may influence memory responses in patients." @default.
• W3039230007 created "2020-07-10" @default.
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• W3039230007 date "2020-06-01" @default.
• W3039230007 modified "2023-10-17" @default.
• W3039230007 title "The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection" @default.
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• W3039230007 doi "https://doi.org/10.1016/j.celrep.2020.107827" @default.
• W3039230007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7377452" @default.
• W3039230007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32610128" @default.
• W3039230007 hasPublicationYear "2020" @default.
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