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• W3039238419 abstract "espanolIntroduccion y objetivos El volumen metabolico tumoral (VMT) es un indicador de pronostico prometedor en el linfoma B difuso de celulas grandes (LBDCG). El objetivo del presente estudio es evaluar los diferentes metodos para el calculo del VMT basal con la tomografia por emision de positrones/tomografia computarizada con 18F-fluorodesoxiglucosa (18F-FDG PET/TC) en pacientes con LBDCG, relacionando cada uno de los volumenes medidos con la supervivencia libre de progresion (SLP) y la supervivencia global (SG). Metodologia Se trata de un estudio de cohortes retrospectivo analitico, en el que se incluyeron 34 pacientes sometidos a un 18F-FDG PET/TC basal previo al tratamiento. Comparamos tres umbrales SUV 2,5, SUV 40% del SUV maximo y SUV medio hepatico (PERCIST), para el calculo de los biomarcadores VMT y glucolisis total de la lesion (TLG) relacionandolos con la SLP y SG. El mejor modelo predictivo se selecciono en funcion del valor de criterio de informacion de Akaike (AIC) despues de realizar una regresion de riesgos proporcionales de Cox. Resultados Con relacion a la SLP, muestran diferencias estadisticamente significativas: VMT 2,5, TLG 2,5, VMT 40%, TLG 40%, VMT y TLG calculados con el umbral PERCIST. Entre estos, el que tiene un AIC menor es VMT 2,5, por lo que se considera el mejor parametro para predecir la SLP. Con respecto a la SG, muestra diferencias estadisticamente significativas: VMT 2,5, VMT y TLG calculados con el umbral PERCIST. Entre estos tres, el que tiene un AIC menor es VMT 2,5, por lo que se considera el mejor parametro para predecir la SG. Ademas, un mayor valor de VMT y TLG, se asocia a peor SLP y SG Conclusion El VMT calculado con el umbral SUV 2,5 parece ser el mejor parametro para predecir la SLP y SG en los pacientes diagnosticados con LBDCG con el 18F-FDG PET/TC. EnglishIntroduction and objectives Metabolic tumor volume (MTV) is a promising indicator of prognosis in diffuse large B-cell lymphoma (DLBCL). The aim of the present study is to evaluate the different methods for the calculation of the basal metabolic tumor volume with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in the patients with DLBCL, relating each one of the volumes measured with progression-free survival (PFS) and overall survival (OS). Methodology This is a retrospective analytical cohort study, in which 34 patients underwent to 18F-FDG PET/CT baseline prior to treatment. We compared three SUV thresholds 2.5, SUV 40% of the maximum SUV and SUV mean hepatic uptake (PERCIST) for the calculation of MTV and total lesion glycolysis (TLG) biomarkers, relating them to the PFS and OS. The best predictive model was selected based on the Akaike‘s information criterion (AIC) after performing a Cox proportional hazards regression. Results In relation to the PFS, they show statistically significant differences: MTV 2.5, TLG 2.5, MTV 40, TLG 40, MTV and TLG calculated with the PERCIST threshold. Among these, the one that has a lower AIC is MTV 2.5, so it is considered the best parameter to predict the PFS. With respect to OS, it shows statistically significant differences: MTV 2.5, VMT and TLG calculated with the PERCIST threshold. Among these three, the one with the lowest AIC is MTV 2.5, which is why it is considered the best parameter to predict OS. In addition, a higher value of MTV and total tumor glycolysis (TLG), is associated with worse PFS and OS Conclusion The MTV calculated with the threshold SUV 2.5 seems to be the best parameter to predict PFS and OS in patients diagnosed with DLBCL with 18F-FDG PET/CT." @default.
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• W3039238419 date "2020-11-01" @default.
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• W3039238419 title "Evaluación del valor pronóstico de los diferentes métodos de cálculo del volumen metabólico tumoral con 18F-FDG PET/TC, en pacientes con linfoma B difuso de células grandes" @default.
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• W3039238419 doi "https://doi.org/10.1016/j.remn.2020.06.007" @default.
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