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- W3039239743 endingPage "4761" @default.
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- W3039239743 abstract "The ductus arteriosus (DA) is a shunt vessel between the aorta and the pulmonary artery during the fetal period that is essential for the normal development of the fetus. Complete closure usually occurs after birth but the vessel might remain open in certain infants, as patent ductus arteriosus (PDA), causing morbidity or mortality. The mechanism of DA closure is a complex process involving an orchestration of cell–matrix interaction between smooth muscle cells (SMC), endothelial cells, and extracellular matrix (ECM). ECM is defined as the noncellular component secreted by cells that consists of macromolecules such as elastin, collagens, proteoglycan, hyaluronan, and noncollagenous glycoproteins. In addition to its role as a physical scaffold, ECM mediates diverse signaling that is critical in development, maintenance, and repair in the cardiovascular system. In this review, we aim to outline the current understandings of ECM and its role in the pathophysiology of PDA, with emphasis on DA remodeling and highlight future outlooks. The molecular diversity and plasticity of ECM present a rich array of potential therapeutic targets for the management of PDA." @default.
- W3039239743 created "2020-07-10" @default.
- W3039239743 creator A5007695335 @default.
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- W3039239743 date "2020-07-04" @default.
- W3039239743 modified "2023-10-12" @default.
- W3039239743 title "Role of Extracellular Matrix in Pathophysiology of Patent Ductus Arteriosus: Emphasis on Vascular Remodeling" @default.
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- W3039239743 doi "https://doi.org/10.3390/ijms21134761" @default.
- W3039239743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7369762" @default.
- W3039239743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32635482" @default.
- W3039239743 hasPublicationYear "2020" @default.
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