Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039259486> ?p ?o ?g. }
- W3039259486 endingPage "104638" @default.
- W3039259486 startingPage "104638" @default.
- W3039259486 abstract "Triclosan (TCS) is commonly used worldwide in a range of personal care and sanitizing products. A number of studies have revealed the presence of TCS in human tissues. It has recently been shown that TCS can interact with AhR in mouse neurons and the one of its effects is the stimulation of reactive oxygen species (ROS) production. Reactive oxygen species perform a wide spectrum of functions in neuronal cells, where they are generated as by-products of cellular metabolism. Therefore the aim of the study was to investigate effects of two synthetic naphthoflavones, the beta-naphthoflavone (βNF) and alpha-naphthoflavone (αNF), well known agonist and antagonist of AhR on TCS-stimulated cytotoxicity, apoptosis and ROS production in mouse primary cortical neurons in vitro cultures. The results showed that both agonist (βNF) and antagonist (αNF) of AhR enhanced the LDH release and caspase-3 activity stimulated by TCS. Interestingly, both naphthoflavones decreased the TCS-stimulated ROS production, however, they showed no scavenging properties as revealed by ABTS•+ and DPPH• methods. What's more, both βNF as well as αNF inhibited the activity of xanthine oxidase (XO) stimulated by TCS. Thus, we can assume that αNF or βNF act in a competitive way over TCS and inhibit its effect on antioxidant enzyme activity." @default.
- W3039259486 created "2020-07-10" @default.
- W3039259486 creator A5022069988 @default.
- W3039259486 creator A5030350384 @default.
- W3039259486 creator A5046611907 @default.
- W3039259486 creator A5049449423 @default.
- W3039259486 date "2020-09-01" @default.
- W3039259486 modified "2023-10-16" @default.
- W3039259486 title "The interference of alpha- and beta-naphthoflavone with triclosan effects on viability, apoptosis and reactive oxygen species production in mouse neocortical neurons" @default.
- W3039259486 cites W1528991278 @default.
- W3039259486 cites W1965721848 @default.
- W3039259486 cites W1975336183 @default.
- W3039259486 cites W1982717166 @default.
- W3039259486 cites W1988664425 @default.
- W3039259486 cites W1995078515 @default.
- W3039259486 cites W1998575939 @default.
- W3039259486 cites W2003902516 @default.
- W3039259486 cites W2008890880 @default.
- W3039259486 cites W2010264974 @default.
- W3039259486 cites W2012991711 @default.
- W3039259486 cites W2023503340 @default.
- W3039259486 cites W2024923464 @default.
- W3039259486 cites W2028971810 @default.
- W3039259486 cites W2034930960 @default.
- W3039259486 cites W2038214163 @default.
- W3039259486 cites W2042992123 @default.
- W3039259486 cites W2044918618 @default.
- W3039259486 cites W2051083360 @default.
- W3039259486 cites W2052783274 @default.
- W3039259486 cites W2062447063 @default.
- W3039259486 cites W2065853716 @default.
- W3039259486 cites W2066446478 @default.
- W3039259486 cites W2076494603 @default.
- W3039259486 cites W2077318232 @default.
- W3039259486 cites W2081145901 @default.
- W3039259486 cites W2083513354 @default.
- W3039259486 cites W2084433959 @default.
- W3039259486 cites W2085273994 @default.
- W3039259486 cites W2089468803 @default.
- W3039259486 cites W2094063441 @default.
- W3039259486 cites W2101537600 @default.
- W3039259486 cites W2110199291 @default.
- W3039259486 cites W2114467922 @default.
- W3039259486 cites W2127778297 @default.
- W3039259486 cites W2133971230 @default.
- W3039259486 cites W2153586723 @default.
- W3039259486 cites W2261347553 @default.
- W3039259486 cites W2300230761 @default.
- W3039259486 cites W2300622504 @default.
- W3039259486 cites W2503430441 @default.
- W3039259486 cites W2568450381 @default.
- W3039259486 cites W2571013059 @default.
- W3039259486 cites W2576498511 @default.
- W3039259486 cites W2578128645 @default.
- W3039259486 cites W2598258837 @default.
- W3039259486 cites W2598934739 @default.
- W3039259486 cites W2607133235 @default.
- W3039259486 cites W2607394075 @default.
- W3039259486 cites W2619880604 @default.
- W3039259486 cites W2790793156 @default.
- W3039259486 cites W2801079612 @default.
- W3039259486 cites W2893882601 @default.
- W3039259486 cites W2897198390 @default.
- W3039259486 cites W2920035930 @default.
- W3039259486 cites W2940274052 @default.
- W3039259486 cites W2954521888 @default.
- W3039259486 cites W4245333844 @default.
- W3039259486 doi "https://doi.org/10.1016/j.pestbp.2020.104638" @default.
- W3039259486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32711772" @default.
- W3039259486 hasPublicationYear "2020" @default.
- W3039259486 type Work @default.
- W3039259486 sameAs 3039259486 @default.
- W3039259486 citedByCount "5" @default.
- W3039259486 countsByYear W30392594862021 @default.
- W3039259486 countsByYear W30392594862022 @default.
- W3039259486 crossrefType "journal-article" @default.
- W3039259486 hasAuthorship W3039259486A5022069988 @default.
- W3039259486 hasAuthorship W3039259486A5030350384 @default.
- W3039259486 hasAuthorship W3039259486A5046611907 @default.
- W3039259486 hasAuthorship W3039259486A5049449423 @default.
- W3039259486 hasConcept C170493617 @default.
- W3039259486 hasConcept C181199279 @default.
- W3039259486 hasConcept C185592680 @default.
- W3039259486 hasConcept C190283241 @default.
- W3039259486 hasConcept C2778004101 @default.
- W3039259486 hasConcept C2778102346 @default.
- W3039259486 hasConcept C2778938600 @default.
- W3039259486 hasConcept C48349386 @default.
- W3039259486 hasConcept C55493867 @default.
- W3039259486 hasConcept C86803240 @default.
- W3039259486 hasConcept C95444343 @default.
- W3039259486 hasConcept C98274493 @default.
- W3039259486 hasConceptScore W3039259486C170493617 @default.
- W3039259486 hasConceptScore W3039259486C181199279 @default.
- W3039259486 hasConceptScore W3039259486C185592680 @default.
- W3039259486 hasConceptScore W3039259486C190283241 @default.
- W3039259486 hasConceptScore W3039259486C2778004101 @default.
- W3039259486 hasConceptScore W3039259486C2778102346 @default.