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• W3039275317 endingPage "2023" @default.
• W3039275317 startingPage "2007" @default.
• W3039275317 abstract "Acidic tumor microenvironment has been extensively explored to design pH-responsive paclitaxel prodrug micelles for cancer therapy. The object of this study is to investigate the pH-responsive drug release behavior and the anti-proliferation capacity of acetal-linked paclitaxel polymeric prodrug micelles. The prodrug was synthesized and evaluated for paclitaxel content. The prodrug micelles were fabricated and characterized for morphology, size, in vitro pH-responsive paclitaxel release, cellular uptake, and anti-proliferation. Paclitaxel content was 33 wt%. The prodrug micelles exhibited spherical structure with the hydrodynamic diameter of 154 nm. Besides, the in vitro paclitaxel release behavior was verified to be pH-responsive, and 77%, 38%, and 17% of parent free paclitaxel was released from the nano-sized prodrug micelles in 13 h at pH 5.5, 6.5, and 7.4, respectively. The cellular uptake assessment demonstrated the time-dependent internalization of prodrug micelles. Meanwhile, CCK-8 analysis showed that prodrug micelles possessed the potent anti-proliferation effects. Prodrug micelles based on aliphatic polycarbonates present a promising platform for cancer chemotherapy due to the pH-responsive characteristics of acetal bond, potent anti-proliferation effects, and outstanding cytocompatibility of aliphatic polycarbonates." @default.
• W3039275317 created "2020-07-10" @default.
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• W3039275317 date "2020-07-20" @default.
• W3039275317 modified "2023-10-12" @default.
• W3039275317 title "Acetal-linked polymeric prodrug micelles based on aliphatic polycarbonates for paclitaxel delivery: preparation, characterization, <i>in vitro</i> release and anti-proliferation effects" @default.
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• W3039275317 doi "https://doi.org/10.1080/09205063.2020.1792046" @default.
• W3039275317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32619161" @default.
• W3039275317 hasPublicationYear "2020" @default.
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