FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039277544> ?p ?o ?g. }

• W3039277544 abstract "Host response biomarkers offer a promising alternative diagnostic solution for identifying acute respiratory infection (ARI) cases involving influenza infection. However, most of the published panels involve multiple genes, which is problematic in clinical settings because polymerase chain reaction (PCR)-based technology is the most widely used genomic technology in these settings, and it can only be used to measure a small number of targets. This study aimed to identify a single-gene biomarker with a high diagnostic accuracy by using integrated bioinformatics analysis with XGBoost. The gene expression profiles in dataset GSE68310 were used to construct a co-expression network using weighted correlation network analysis (WGCNA). Fourteen hub genes related to influenza infection (blue module) that were common to both the co-expression network and the protein-protein interaction network were identified. Thereafter, a single hub gene was selected using XGBoost, with feature selection conducted using recursive feature elimination with cross-validation (RFECV). The identified biomarker was oligoadenylate synthetases-like (OASL). The robustness of this biomarker was further examined using three external datasets. OASL expression profiling triggered by various infections was different enough to discriminate between influenza and non-influenza ARI infections. Thus, this study presented a workflow to identify a single-gene classifier across multiple datasets. Moreover, OASL was revealed as a biomarker that could identify influenza patients from among those with flu-like ARI. OASL has great potential for improving influenza diagnosis accuracy in ARI patients in the clinical setting." @default.
• W3039277544 created "2020-07-10" @default.
• W3039277544 creator A5016609966 @default.
• W3039277544 creator A5021295192 @default.
• W3039277544 creator A5032130196 @default.
• W3039277544 creator A5038572440 @default.
• W3039277544 creator A5044544424 @default.
• W3039277544 creator A5047701629 @default.
• W3039277544 creator A5063975762 @default.
• W3039277544 creator A5078433604 @default.
• W3039277544 creator A5080943944 @default.
• W3039277544 creator A5083203760 @default.
• W3039277544 date "2020-07-02" @default.
• W3039277544 modified "2023-09-27" @default.
• W3039277544 title "OASL as a Diagnostic Marker for Influenza Infection Revealed by Integrative Bioinformatics Analysis With XGBoost" @default.
• W3039277544 cites W1966327575 @default.
• W3039277544 cites W1973221350 @default.
• W3039277544 cites W1978527132 @default.
• W3039277544 cites W2006617902 @default.
• W3039277544 cites W2009518589 @default.
• W3039277544 cites W2035618305 @default.
• W3039277544 cites W2038698914 @default.
• W3039277544 cites W2052633053 @default.
• W3039277544 cites W2068353535 @default.
• W3039277544 cites W2069869279 @default.
• W3039277544 cites W2103017472 @default.
• W3039277544 cites W2103912979 @default.
• W3039277544 cites W2106608030 @default.
• W3039277544 cites W2114805242 @default.
• W3039277544 cites W2120839730 @default.
• W3039277544 cites W2146512944 @default.
• W3039277544 cites W2159675211 @default.
• W3039277544 cites W2218326748 @default.
• W3039277544 cites W2273717373 @default.
• W3039277544 cites W2274116767 @default.
• W3039277544 cites W2285903333 @default.
• W3039277544 cites W2474277182 @default.
• W3039277544 cites W2517204460 @default.
• W3039277544 cites W2559588208 @default.
• W3039277544 cites W2620416311 @default.
• W3039277544 cites W2625889480 @default.
• W3039277544 cites W2897215926 @default.
• W3039277544 cites W2900569176 @default.
• W3039277544 cites W2914888844 @default.
• W3039277544 cites W3102476541 @default.
• W3039277544 cites W582147111 @default.
• W3039277544 doi "https://doi.org/10.3389/fbioe.2020.00729" @default.
• W3039277544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7343705" @default.
• W3039277544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32714913" @default.
• W3039277544 hasPublicationYear "2020" @default.
• W3039277544 type Work @default.
• W3039277544 sameAs 3039277544 @default.
• W3039277544 citedByCount "7" @default.
• W3039277544 countsByYear W30392775442020 @default.
• W3039277544 countsByYear W30392775442021 @default.
• W3039277544 countsByYear W30392775442022 @default.
• W3039277544 countsByYear W30392775442023 @default.
• W3039277544 crossrefType "journal-article" @default.
• W3039277544 hasAuthorship W3039277544A5016609966 @default.
• W3039277544 hasAuthorship W3039277544A5021295192 @default.
• W3039277544 hasAuthorship W3039277544A5032130196 @default.
• W3039277544 hasAuthorship W3039277544A5038572440 @default.
• W3039277544 hasAuthorship W3039277544A5044544424 @default.
• W3039277544 hasAuthorship W3039277544A5047701629 @default.
• W3039277544 hasAuthorship W3039277544A5063975762 @default.
• W3039277544 hasAuthorship W3039277544A5078433604 @default.
• W3039277544 hasAuthorship W3039277544A5080943944 @default.
• W3039277544 hasAuthorship W3039277544A5083203760 @default.
• W3039277544 hasBestOaLocation W30392775441 @default.
• W3039277544 hasConcept C104317684 @default.
• W3039277544 hasConcept C124535831 @default.
• W3039277544 hasConcept C150194340 @default.
• W3039277544 hasConcept C18431079 @default.
• W3039277544 hasConcept C2781197716 @default.
• W3039277544 hasConcept C46111723 @default.
• W3039277544 hasConcept C54355233 @default.
• W3039277544 hasConcept C60644358 @default.
• W3039277544 hasConcept C67339327 @default.
• W3039277544 hasConcept C70721500 @default.
• W3039277544 hasConcept C86803240 @default.
• W3039277544 hasConceptScore W3039277544C104317684 @default.
• W3039277544 hasConceptScore W3039277544C124535831 @default.
• W3039277544 hasConceptScore W3039277544C150194340 @default.
• W3039277544 hasConceptScore W3039277544C18431079 @default.
• W3039277544 hasConceptScore W3039277544C2781197716 @default.
• W3039277544 hasConceptScore W3039277544C46111723 @default.
• W3039277544 hasConceptScore W3039277544C54355233 @default.
• W3039277544 hasConceptScore W3039277544C60644358 @default.
• W3039277544 hasConceptScore W3039277544C67339327 @default.
• W3039277544 hasConceptScore W3039277544C70721500 @default.
• W3039277544 hasConceptScore W3039277544C86803240 @default.
• W3039277544 hasLocation W30392775441 @default.
• W3039277544 hasLocation W30392775442 @default.
• W3039277544 hasLocation W30392775443 @default.
• W3039277544 hasLocation W30392775444 @default.
• W3039277544 hasOpenAccess W3039277544 @default.
• W3039277544 hasPrimaryLocation W30392775441 @default.
• W3039277544 hasRelatedWork W1597363747 @default.
• W3039277544 hasRelatedWork W166274801 @default.
• W3039277544 hasRelatedWork W1971166208 @default.

• next