Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039279833> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3039279833 endingPage "1555" @default.
- W3039279833 startingPage "1553" @default.
- W3039279833 abstract "The antimalarial drug lumefantrine exhibits erratic pharmacokinetics. Intersubject variability might be attributed, in part, to differences in gut microbiome–mediated drug metabolism. We assessed lumefantrine disposition in healthy mice stratified by enterotype to explore associations between the gut microbiota and lumefantrine pharmacokinetics. Gut microbiota enterotypes were classified according to abundance and diversity indices from 16S rRNA sequencing. Pharmacokinetic parameters were computed using noncompartmental analysis. Two distinct enterotypes were identified. Maximal concentration (Cmax) and total drug exposure measured as the area under the drug concentration–time curve (AUC0–24) differed significantly between the groups. The mean and standard deviation of Cmax were 660 ± 220 ng/mL versus 390 ± 59 ng/mL (P = 0.02), and AUC0–24 was 9,600 ± 2,800 versus 5,800 ± 810 ng × h/mL (P = 0.01). In healthy mice intragastrically dosed with the antimalarial drug lumefantrine in combination with artemether, lumefantrine exposure was associated with gut bacterial community structure. Studies of xenobiotic–microbiota interactions can inform drug posology and elucidate mechanisms of drug disposition." @default.
- W3039279833 created "2020-07-10" @default.
- W3039279833 creator A5013612221 @default.
- W3039279833 creator A5026922666 @default.
- W3039279833 creator A5073102114 @default.
- W3039279833 creator A5077230926 @default.
- W3039279833 creator A5079252369 @default.
- W3039279833 date "2020-10-07" @default.
- W3039279833 modified "2023-10-12" @default.
- W3039279833 title "Evidence of Microbiome–Drug Interaction between the Antimalarial Lumefantrine and Gut Microbiota in Mice" @default.
- W3039279833 cites W2034446643 @default.
- W3039279833 cites W2053811616 @default.
- W3039279833 cites W2061156796 @default.
- W3039279833 cites W2072970694 @default.
- W3039279833 cites W2090726723 @default.
- W3039279833 cites W2097478615 @default.
- W3039279833 cites W2170024099 @default.
- W3039279833 cites W2256712352 @default.
- W3039279833 cites W2892657299 @default.
- W3039279833 cites W2911990720 @default.
- W3039279833 cites W2914718086 @default.
- W3039279833 cites W2919022009 @default.
- W3039279833 doi "https://doi.org/10.4269/ajtmh.20-0333" @default.
- W3039279833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7543808" @default.
- W3039279833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32618266" @default.
- W3039279833 hasPublicationYear "2020" @default.
- W3039279833 type Work @default.
- W3039279833 sameAs 3039279833 @default.
- W3039279833 citedByCount "1" @default.
- W3039279833 countsByYear W30392798332022 @default.
- W3039279833 crossrefType "journal-article" @default.
- W3039279833 hasAuthorship W3039279833A5013612221 @default.
- W3039279833 hasAuthorship W3039279833A5026922666 @default.
- W3039279833 hasAuthorship W3039279833A5073102114 @default.
- W3039279833 hasAuthorship W3039279833A5077230926 @default.
- W3039279833 hasAuthorship W3039279833A5079252369 @default.
- W3039279833 hasBestOaLocation W30392798331 @default.
- W3039279833 hasConcept C112705442 @default.
- W3039279833 hasConcept C143121216 @default.
- W3039279833 hasConcept C203014093 @default.
- W3039279833 hasConcept C22979827 @default.
- W3039279833 hasConcept C2776120307 @default.
- W3039279833 hasConcept C2778048844 @default.
- W3039279833 hasConcept C2778371730 @default.
- W3039279833 hasConcept C2778629330 @default.
- W3039279833 hasConcept C2780035454 @default.
- W3039279833 hasConcept C2780780316 @default.
- W3039279833 hasConcept C539455810 @default.
- W3039279833 hasConcept C60644358 @default.
- W3039279833 hasConcept C71924100 @default.
- W3039279833 hasConcept C76318530 @default.
- W3039279833 hasConcept C86803240 @default.
- W3039279833 hasConcept C98274493 @default.
- W3039279833 hasConceptScore W3039279833C112705442 @default.
- W3039279833 hasConceptScore W3039279833C143121216 @default.
- W3039279833 hasConceptScore W3039279833C203014093 @default.
- W3039279833 hasConceptScore W3039279833C22979827 @default.
- W3039279833 hasConceptScore W3039279833C2776120307 @default.
- W3039279833 hasConceptScore W3039279833C2778048844 @default.
- W3039279833 hasConceptScore W3039279833C2778371730 @default.
- W3039279833 hasConceptScore W3039279833C2778629330 @default.
- W3039279833 hasConceptScore W3039279833C2780035454 @default.
- W3039279833 hasConceptScore W3039279833C2780780316 @default.
- W3039279833 hasConceptScore W3039279833C539455810 @default.
- W3039279833 hasConceptScore W3039279833C60644358 @default.
- W3039279833 hasConceptScore W3039279833C71924100 @default.
- W3039279833 hasConceptScore W3039279833C76318530 @default.
- W3039279833 hasConceptScore W3039279833C86803240 @default.
- W3039279833 hasConceptScore W3039279833C98274493 @default.
- W3039279833 hasIssue "4" @default.
- W3039279833 hasLocation W30392798331 @default.
- W3039279833 hasLocation W30392798332 @default.
- W3039279833 hasLocation W30392798333 @default.
- W3039279833 hasLocation W30392798334 @default.
- W3039279833 hasOpenAccess W3039279833 @default.
- W3039279833 hasPrimaryLocation W30392798331 @default.
- W3039279833 hasRelatedWork W1967512152 @default.
- W3039279833 hasRelatedWork W2007933951 @default.
- W3039279833 hasRelatedWork W2102965958 @default.
- W3039279833 hasRelatedWork W2125585793 @default.
- W3039279833 hasRelatedWork W2350403668 @default.
- W3039279833 hasRelatedWork W3084122795 @default.
- W3039279833 hasRelatedWork W3092052599 @default.
- W3039279833 hasRelatedWork W3166570314 @default.
- W3039279833 hasRelatedWork W4244223763 @default.
- W3039279833 hasRelatedWork W2026222656 @default.
- W3039279833 hasVolume "103" @default.
- W3039279833 isParatext "false" @default.
- W3039279833 isRetracted "false" @default.
- W3039279833 magId "3039279833" @default.
- W3039279833 workType "article" @default.