FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039302293> ?p ?o ?g. }

• W3039302293 endingPage "577" @default.
• W3039302293 startingPage "560" @default.
• W3039302293 abstract "Specialization of many cells, including the acinar cells of the salivary glands and pancreas, milk-producing cells of mammary glands, mucus-secreting goblet cells, antibody-producing plasma cells, and cells that generate the dense extracellular matrices of bone and cartilage, requires scaling up both secretory machinery and cell-type specific secretory cargo. Using tissue-specific genome-scale analyses, we determine how increases in secretory capacity are coordinated with increases in secretory load in the Drosophila salivary gland (SG), an ideal model for gaining mechanistic insight into the functional specialization of secretory organs. Our findings show that CrebA, a bZIP transcription factor, directly binds genes encoding the core secretory machinery, including protein components of the signal recognition particle and receptor, ER cargo translocators, Cop I and Cop II vesicles, as well as the structural proteins and enzymes of these organelles. CrebA directly binds a subset of SG cargo genes and CrebA binds and boosts expression of Sage, a SG-specific transcription factor essential for cargo expression. To further enhance secretory output, CrebA binds and activates Xbp1 and Tudor-SN. Thus, CrebA directly upregulates the machinery of secretion and additional factors to increase overall secretory capacity in professional secretory cells; concomitant increases in cargo are achieved both directly and indirectly." @default.
• W3039302293 created "2020-07-10" @default.
• W3039302293 creator A5003368129 @default.
• W3039302293 creator A5023116799 @default.
• W3039302293 creator A5041627138 @default.
• W3039302293 creator A5042173388 @default.
• W3039302293 creator A5047474501 @default.
• W3039302293 creator A5058132242 @default.
• W3039302293 creator A5066162680 @default.
• W3039302293 creator A5066938712 @default.
• W3039302293 creator A5069610584 @default.
• W3039302293 date "2020-08-18" @default.
• W3039302293 modified "2023-10-06" @default.
• W3039302293 title "Creb<scp>A</scp>increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators" @default.
• W3039302293 cites W1529217091 @default.
• W3039302293 cites W1697178647 @default.
• W3039302293 cites W1733558362 @default.
• W3039302293 cites W1927398280 @default.
• W3039302293 cites W1971727593 @default.
• W3039302293 cites W1975159690 @default.
• W3039302293 cites W1979075281 @default.
• W3039302293 cites W1984297099 @default.
• W3039302293 cites W1989956075 @default.
• W3039302293 cites W1993456009 @default.
• W3039302293 cites W1997017455 @default.
• W3039302293 cites W2016087279 @default.
• W3039302293 cites W2018438969 @default.
• W3039302293 cites W2042466557 @default.
• W3039302293 cites W2053352747 @default.
• W3039302293 cites W2058552632 @default.
• W3039302293 cites W2063074039 @default.
• W3039302293 cites W2070924960 @default.
• W3039302293 cites W2076880493 @default.
• W3039302293 cites W2084625759 @default.
• W3039302293 cites W2089834604 @default.
• W3039302293 cites W2099143842 @default.
• W3039302293 cites W2102619694 @default.
• W3039302293 cites W2104335085 @default.
• W3039302293 cites W2107424466 @default.
• W3039302293 cites W2124064920 @default.
• W3039302293 cites W2125362831 @default.
• W3039302293 cites W2125841178 @default.
• W3039302293 cites W2133465414 @default.
• W3039302293 cites W2135185213 @default.
• W3039302293 cites W2148609464 @default.
• W3039302293 cites W2154395280 @default.
• W3039302293 cites W2154500525 @default.
• W3039302293 cites W2157009395 @default.
• W3039302293 cites W2158217645 @default.
• W3039302293 cites W2163049570 @default.
• W3039302293 cites W2169636861 @default.
• W3039302293 cites W2170830174 @default.
• W3039302293 cites W2170964754 @default.
• W3039302293 cites W2171808845 @default.
• W3039302293 cites W2187168332 @default.
• W3039302293 cites W2207442238 @default.
• W3039302293 cites W2209585205 @default.
• W3039302293 cites W2330553172 @default.
• W3039302293 cites W2529751801 @default.
• W3039302293 cites W2613916037 @default.
• W3039302293 cites W2626395293 @default.
• W3039302293 cites W2749710285 @default.
• W3039302293 cites W2777064170 @default.
• W3039302293 cites W2786758975 @default.
• W3039302293 cites W2790023639 @default.
• W3039302293 cites W2790264760 @default.
• W3039302293 cites W2809554459 @default.
• W3039302293 cites W2898204371 @default.
• W3039302293 cites W2917207851 @default.
• W3039302293 cites W2949274170 @default.
• W3039302293 cites W2952053464 @default.
• W3039302293 cites W2971951026 @default.
• W3039302293 cites W34905309 @default.
• W3039302293 doi "https://doi.org/10.1111/tra.12753" @default.
• W3039302293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8142552" @default.
• W3039302293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32613751" @default.
• W3039302293 hasPublicationYear "2020" @default.
• W3039302293 type Work @default.
• W3039302293 sameAs 3039302293 @default.
• W3039302293 citedByCount "13" @default.
• W3039302293 countsByYear W30393022932020 @default.
• W3039302293 countsByYear W30393022932021 @default.
• W3039302293 countsByYear W30393022932022 @default.
• W3039302293 countsByYear W30393022932023 @default.
• W3039302293 crossrefType "journal-article" @default.
• W3039302293 hasAuthorship W3039302293A5003368129 @default.
• W3039302293 hasAuthorship W3039302293A5023116799 @default.
• W3039302293 hasAuthorship W3039302293A5041627138 @default.
• W3039302293 hasAuthorship W3039302293A5042173388 @default.
• W3039302293 hasAuthorship W3039302293A5047474501 @default.
• W3039302293 hasAuthorship W3039302293A5058132242 @default.
• W3039302293 hasAuthorship W3039302293A5066162680 @default.
• W3039302293 hasAuthorship W3039302293A5066938712 @default.
• W3039302293 hasAuthorship W3039302293A5069610584 @default.
• W3039302293 hasBestOaLocation W30393022931 @default.
• W3039302293 hasConcept C104317684 @default.
• W3039302293 hasConcept C119062480 @default.
• W3039302293 hasConcept C156399914 @default.

• next