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- W3039333411 abstract "Abstract During development, naïve cells gradually acquire distinct cell fates, through sophisticated mechanisms of precise spatio-temporal gene regulation. Acquisition of cell fate is thought to rely on the specific interaction of remote cis -regulatory modules (e.g. enhancers, silencers) (CRM) and target promoters. However, the precise interplay between chromatin structure and gene expression is still unclear, particularly in single cells within multicellular developing organisms. Here we employ Hi-M, a single-cell spatial genomics approach, to systematically detect CRM-promoter looping interactions within topological associating domains (TADs) during Drosophila development. By comparing cis -regulatory loops in alternate cell types, we show that physical proximity does not necessarily instruct transcriptional states. Moreover, multi-way analyses revealed the existence of local interactions between multiple remote CRMs to form hubs. We found that loops and CRM hubs are established early during development, prior to the emergence of TADs. Moreover, CRM hubs are formed via the action of the pioneer transcription factor Zelda and precede transcriptional activation. Our approach offers a new perspective on the role of CRM-promoter interactions in defining transcriptional activation and repression states, as well as distinct cell types." @default.
- W3039333411 created "2020-07-10" @default.
- W3039333411 creator A5009574425 @default.
- W3039333411 creator A5014210983 @default.
- W3039333411 creator A5015356981 @default.
- W3039333411 creator A5028537170 @default.
- W3039333411 creator A5038118676 @default.
- W3039333411 creator A5052270400 @default.
- W3039333411 creator A5063155873 @default.
- W3039333411 creator A5078835009 @default.
- W3039333411 date "2020-07-07" @default.
- W3039333411 modified "2023-10-08" @default.
- W3039333411 title "<i>Cis</i>-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during development" @default.
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