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- W3039340965 endingPage "101195" @default.
- W3039340965 startingPage "101195" @default.
- W3039340965 abstract "The myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are a heterogenous group of myeloid malignancies hallmarked by clinicopathologic features that overlap with myelodysplastic syndromes and myeloproliferative neoplasms. Formally recognized by the World Health Organization, this group includes the entities chronic myelomonocytic leukemia, juvenile myelomonocytic leukemia, atypical chronic myeloid leukemia, MDS/MPN with ring sideroblasts and thrombocytosis and MDS/MPN, unclassifiable. Advancements in next generation sequencing have begun to unravel the molecular underpinnings of these diseases, identifying an array of recurrently mutated genes involved in epigenetic regulation, RNA splicing, transcription, and cell signaling. Despite molecular overlap with other myeloid malignancies, each entity displays a unique spectrum of somatic mutations supporting their unique pathobiology and clinical features. Importantly, molecular profiling is becoming an integral tool utilized in routine clinical practice. This review summarizes our current understanding of the molecular pathogenesis of overlap syndromes and details the impact of somatic mutations in diagnostic, prognostic, and therapeutic decision-making." @default.
- W3039340965 created "2020-07-10" @default.
- W3039340965 creator A5020631581 @default.
- W3039340965 creator A5041754278 @default.
- W3039340965 date "2020-09-01" @default.
- W3039340965 modified "2023-10-16" @default.
- W3039340965 title "Molecular genetics of MDS/MPN overlap syndromes" @default.
- W3039340965 cites W1498250169 @default.
- W3039340965 cites W1656026419 @default.
- W3039340965 cites W1889574318 @default.
- W3039340965 cites W1948939232 @default.
- W3039340965 cites W1963865821 @default.
- W3039340965 cites W1965033113 @default.
- W3039340965 cites W1972914723 @default.
- W3039340965 cites W1983611328 @default.
- W3039340965 cites W1993236149 @default.
- W3039340965 cites W1993685021 @default.
- W3039340965 cites W1994924914 @default.
- W3039340965 cites W1996101136 @default.
- W3039340965 cites W2001048486 @default.
- W3039340965 cites W2007580297 @default.
- W3039340965 cites W2015157349 @default.
- W3039340965 cites W2016329514 @default.
- W3039340965 cites W2026010924 @default.
- W3039340965 cites W2029679731 @default.
- W3039340965 cites W2033721263 @default.
- W3039340965 cites W2037984374 @default.
- W3039340965 cites W2052505035 @default.
- W3039340965 cites W2056589782 @default.
- W3039340965 cites W2066210952 @default.
- W3039340965 cites W2067257787 @default.
- W3039340965 cites W2075614812 @default.
- W3039340965 cites W2082448876 @default.
- W3039340965 cites W2084334750 @default.
- W3039340965 cites W2094640639 @default.
- W3039340965 cites W2095066915 @default.
- W3039340965 cites W2096102839 @default.
- W3039340965 cites W2096638244 @default.
- W3039340965 cites W2104599144 @default.
- W3039340965 cites W2105248187 @default.
- W3039340965 cites W2109840335 @default.
- W3039340965 cites W2121743767 @default.
- W3039340965 cites W2125746373 @default.
- W3039340965 cites W2131444433 @default.
- W3039340965 cites W2134878671 @default.
- W3039340965 cites W2138122783 @default.
- W3039340965 cites W2140419897 @default.
- W3039340965 cites W2146275856 @default.
- W3039340965 cites W2149089431 @default.
- W3039340965 cites W2155046477 @default.
- W3039340965 cites W2160873970 @default.
- W3039340965 cites W2162079601 @default.
- W3039340965 cites W2179401874 @default.
- W3039340965 cites W220016304 @default.
- W3039340965 cites W2236323615 @default.
- W3039340965 cites W2263083658 @default.
- W3039340965 cites W2271038606 @default.
- W3039340965 cites W2300078413 @default.
- W3039340965 cites W2302493965 @default.
- W3039340965 cites W2323602978 @default.
- W3039340965 cites W2339658711 @default.
- W3039340965 cites W2465481988 @default.
- W3039340965 cites W2473994407 @default.
- W3039340965 cites W2500218405 @default.
- W3039340965 cites W2559313212 @default.
- W3039340965 cites W2586125700 @default.
- W3039340965 cites W2587066646 @default.
- W3039340965 cites W2589411765 @default.
- W3039340965 cites W2598911025 @default.
- W3039340965 cites W2605318061 @default.
- W3039340965 cites W2607063630 @default.
- W3039340965 cites W2617816639 @default.
- W3039340965 cites W2752628798 @default.
- W3039340965 cites W2761473242 @default.
- W3039340965 cites W2767798380 @default.
- W3039340965 cites W2770293018 @default.
- W3039340965 cites W2770503151 @default.
- W3039340965 cites W2800637362 @default.
- W3039340965 cites W2892085072 @default.
- W3039340965 cites W2909410317 @default.
- W3039340965 cites W2943165310 @default.
- W3039340965 cites W2972844745 @default.
- W3039340965 cites W2983543368 @default.
- W3039340965 cites W2984640173 @default.
- W3039340965 cites W2987458761 @default.
- W3039340965 cites W2987762913 @default.
- W3039340965 cites W2998901800 @default.
- W3039340965 doi "https://doi.org/10.1016/j.beha.2020.101195" @default.
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