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• W3039341641 abstract "Purpose of review Antibody–drug conjugates (ADCs) represent a new class of drugs that combine a surface receptor-targeting antibody linked to a cytotoxic molecule. This review summarizes the current literature demonstrating their tremendous promise as therapeutic agents in the treatment of aggressive gynecologic malignancies. Recent findings Several antigens have proven to be differentially overexpressed in a variety of gynecologic tumors when compared with normal surrounding tissue and serve as novel targets for ADC therapy. In the last few years HER2/neu, folic acid-alpha (FRα) and Trop-2 overexpression have been exploited as excellent targets by novel ADCs such as Trastuzumab emtansine (T-DM1), SYD985, IMGN853 (Mirvetuximab soravtansine) and Sacituzumab govitecan (SG, IMMU-132) in multiple tumors including ovarian, endometrial and cervical cancers. Although the selectivity of ADCs with noncleavable linkers (i.e. T-DM1) has shown negligible effect on surrounding antigen negative cells, those ADCs with cleavable linkers (i.e. SYD985, IMGN853 and SG) may kill both antigen-positive target cells and surrounding antigen-negative cells via the bystander effect. Summary Preclinical data strongly supports these ADCs and ongoing clinical trials will shed further light into the potential of making these drugs part of current standard practice and providing our patients with a higher level of personalized cancer care." @default.
• W3039341641 created "2020-07-10" @default.
• W3039341641 creator A5003477055 @default.
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• W3039341641 date "2020-06-29" @default.
• W3039341641 modified "2023-10-16" @default.
• W3039341641 title "Novel antibody–drug conjugates: current and future roles in gynecologic oncology" @default.
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• W3039341641 doi "https://doi.org/10.1097/gco.0000000000000642" @default.
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• W3039341641 hasPublicationYear "2020" @default.
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