FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039346962> ?p ?o ?g. }

• W3039346962 abstract "We found evidence of dynamic scaling in the spreading of Madin-Darby canine kidney (MDCK) cell monolayer, which can be characterized by the Hurst exponent $ensuremath{alpha}=0.86$ and the growth exponent $ensuremath{beta}=0.73$, and theoretically and experimentally clarified the mechanism that governs the contour shape dynamics. Dynamic scaling refers to the roughness of the surface scales, both spatially and temporally. During the spreading of the monolayer, it is known that so-called leader cells generate the driving force and lead the other cells. Our time-lapse observations of cell behavior showed that these leader cells appeared at the early stage of the spreading and formed the monolayer protrusion. Informed by these observations, we developed a simple mathematical model that included differences in cell motility, cell-cell adhesion, and random cell movement. The model reproduced the quantitative characteristics obtained from the experiment, such as the spreading speed, the distribution of the increment, and the dynamic scaling law. Analysis of the model equation shows that the model can reproduce different scaling laws from $(ensuremath{alpha}=0.5,ensuremath{beta}=0.25)$ to $(ensuremath{alpha}=0.9,ensuremath{beta}=0.75)$, where the exponents $ensuremath{alpha}$ and $ensuremath{beta}$ are determined by two dimensionless quantities determined by the microscopic cell behavior. From the analytical result, parameter estimation from the experimental results was achieved. The monolayer on the collagen-coated dishes showed a different scaling law, $ensuremath{alpha}=0.74,ensuremath{beta}=0.68$, suggesting that cell motility increased ninefold. This result was consistent with the assay of the single-cell motility. Our study demonstrated that the dynamics of the contour of the monolayer were explained by the simple model, and we propose a mechanism that exhibits the dynamic scaling property." @default.
• W3039346962 created "2020-07-10" @default.
• W3039346962 creator A5013530666 @default.
• W3039346962 creator A5038146146 @default.
• W3039346962 creator A5055086720 @default.
• W3039346962 date "2020-12-04" @default.
• W3039346962 modified "2023-09-27" @default.
• W3039346962 title "Mechanism underlying dynamic scaling properties observed in the contour of spreading epithelial monolayer" @default.
• W3039346962 cites W1907126089 @default.
• W3039346962 cites W1963739427 @default.
• W3039346962 cites W1964755274 @default.
• W3039346962 cites W1975472487 @default.
• W3039346962 cites W1978944068 @default.
• W3039346962 cites W1982115118 @default.
• W3039346962 cites W1991169338 @default.
• W3039346962 cites W1993153669 @default.
• W3039346962 cites W1998506673 @default.
• W3039346962 cites W2012778906 @default.
• W3039346962 cites W2015330218 @default.
• W3039346962 cites W2022593932 @default.
• W3039346962 cites W2028815830 @default.
• W3039346962 cites W2033120183 @default.
• W3039346962 cites W2040034548 @default.
• W3039346962 cites W2040843328 @default.
• W3039346962 cites W2048242269 @default.
• W3039346962 cites W2063220206 @default.
• W3039346962 cites W2075536913 @default.
• W3039346962 cites W2079425770 @default.
• W3039346962 cites W2087496472 @default.
• W3039346962 cites W2088046890 @default.
• W3039346962 cites W2089376707 @default.
• W3039346962 cites W2094098398 @default.
• W3039346962 cites W2095491615 @default.
• W3039346962 cites W2162658340 @default.
• W3039346962 cites W2206592217 @default.
• W3039346962 cites W2225115505 @default.
• W3039346962 cites W2332767074 @default.
• W3039346962 cites W2427489601 @default.
• W3039346962 cites W2529052661 @default.
• W3039346962 cites W2594380017 @default.
• W3039346962 cites W2598845049 @default.
• W3039346962 cites W2614040375 @default.
• W3039346962 cites W2748386604 @default.
• W3039346962 cites W2888091086 @default.
• W3039346962 cites W2919052965 @default.
• W3039346962 cites W2953138240 @default.
• W3039346962 cites W2968378212 @default.
• W3039346962 cites W2994898027 @default.
• W3039346962 cites W3098725301 @default.
• W3039346962 cites W3101920236 @default.
• W3039346962 cites W4231518691 @default.
• W3039346962 doi "https://doi.org/10.1103/physreve.102.062408" @default.
• W3039346962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33466041" @default.
• W3039346962 hasPublicationYear "2020" @default.
• W3039346962 type Work @default.
• W3039346962 sameAs 3039346962 @default.
• W3039346962 citedByCount "1" @default.
• W3039346962 countsByYear W30393469622023 @default.
• W3039346962 crossrefType "journal-article" @default.
• W3039346962 hasAuthorship W3039346962A5013530666 @default.
• W3039346962 hasAuthorship W3039346962A5038146146 @default.
• W3039346962 hasAuthorship W3039346962A5055086720 @default.
• W3039346962 hasBestOaLocation W30393469622 @default.
• W3039346962 hasConcept C121332964 @default.
• W3039346962 hasConcept C138885662 @default.
• W3039346962 hasConcept C171250308 @default.
• W3039346962 hasConcept C192562407 @default.
• W3039346962 hasConcept C199360897 @default.
• W3039346962 hasConcept C24872484 @default.
• W3039346962 hasConcept C2524010 @default.
• W3039346962 hasConcept C26873012 @default.
• W3039346962 hasConcept C2776174256 @default.
• W3039346962 hasConcept C2780388253 @default.
• W3039346962 hasConcept C2780500908 @default.
• W3039346962 hasConcept C2988430800 @default.
• W3039346962 hasConcept C33923547 @default.
• W3039346962 hasConcept C41008148 @default.
• W3039346962 hasConcept C41895202 @default.
• W3039346962 hasConcept C57879066 @default.
• W3039346962 hasConcept C7070889 @default.
• W3039346962 hasConcept C99844830 @default.
• W3039346962 hasConceptScore W3039346962C121332964 @default.
• W3039346962 hasConceptScore W3039346962C138885662 @default.
• W3039346962 hasConceptScore W3039346962C171250308 @default.
• W3039346962 hasConceptScore W3039346962C192562407 @default.
• W3039346962 hasConceptScore W3039346962C199360897 @default.
• W3039346962 hasConceptScore W3039346962C24872484 @default.
• W3039346962 hasConceptScore W3039346962C2524010 @default.
• W3039346962 hasConceptScore W3039346962C26873012 @default.
• W3039346962 hasConceptScore W3039346962C2776174256 @default.
• W3039346962 hasConceptScore W3039346962C2780388253 @default.
• W3039346962 hasConceptScore W3039346962C2780500908 @default.
• W3039346962 hasConceptScore W3039346962C2988430800 @default.
• W3039346962 hasConceptScore W3039346962C33923547 @default.
• W3039346962 hasConceptScore W3039346962C41008148 @default.
• W3039346962 hasConceptScore W3039346962C41895202 @default.
• W3039346962 hasConceptScore W3039346962C57879066 @default.
• W3039346962 hasConceptScore W3039346962C7070889 @default.
• W3039346962 hasConceptScore W3039346962C99844830 @default.
• W3039346962 hasFunder F4320315052 @default.

• next