Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039347241> ?p ?o ?g. }
- W3039347241 endingPage "1626" @default.
- W3039347241 startingPage "1620" @default.
- W3039347241 abstract "Kinases represent one of the most intensively pursued groups of targets in modern-day drug discovery. Often it is desirable to achieve selective inhibition of the kinase of interest over the remaining ∼500 kinases in the human kinome. This is especially true when inhibitors are intended to be used to study the biology of the target of interest. We present a pipeline of open-source software that analyzes public domain data to repurpose compounds that have been used in previous kinase inhibitor development projects. We define the dual-specificity tyrosine-regulated kinase 1A (DYRK1A) as the kinase of interest, and by addition of a single methyl group to the chosen starting point we remove glycogen synthase kinase β (GSK3β) and cyclin-dependent kinase (CDK) inhibition. Thus, in an efficient manner we repurpose a GSK3β/CDK chemotype to deliver 8b, a highly selective DYRK1A inhibitor." @default.
- W3039347241 created "2020-07-10" @default.
- W3039347241 creator A5017647626 @default.
- W3039347241 creator A5020842804 @default.
- W3039347241 creator A5026301472 @default.
- W3039347241 creator A5034364371 @default.
- W3039347241 creator A5046678810 @default.
- W3039347241 creator A5052226453 @default.
- W3039347241 creator A5054228857 @default.
- W3039347241 creator A5087947375 @default.
- W3039347241 date "2020-06-30" @default.
- W3039347241 modified "2023-10-16" @default.
- W3039347241 title "Mining Public Domain Data to Develop Selective DYRK1A Inhibitors" @default.
- W3039347241 cites W1569593946 @default.
- W3039347241 cites W1608240838 @default.
- W3039347241 cites W1831651395 @default.
- W3039347241 cites W1891334654 @default.
- W3039347241 cites W1918079945 @default.
- W3039347241 cites W1957658076 @default.
- W3039347241 cites W1975875968 @default.
- W3039347241 cites W1979900513 @default.
- W3039347241 cites W1987138662 @default.
- W3039347241 cites W1995346182 @default.
- W3039347241 cites W2011253324 @default.
- W3039347241 cites W2016575780 @default.
- W3039347241 cites W2036384121 @default.
- W3039347241 cites W2040716278 @default.
- W3039347241 cites W2044935263 @default.
- W3039347241 cites W2058589383 @default.
- W3039347241 cites W2058968970 @default.
- W3039347241 cites W2064264167 @default.
- W3039347241 cites W2070186790 @default.
- W3039347241 cites W2086286404 @default.
- W3039347241 cites W2117905439 @default.
- W3039347241 cites W2120771633 @default.
- W3039347241 cites W2125851351 @default.
- W3039347241 cites W2152265294 @default.
- W3039347241 cites W2152705959 @default.
- W3039347241 cites W2166594615 @default.
- W3039347241 cites W2468259612 @default.
- W3039347241 cites W2595826333 @default.
- W3039347241 cites W2740631829 @default.
- W3039347241 cites W2830873838 @default.
- W3039347241 cites W2891820340 @default.
- W3039347241 cites W2907422278 @default.
- W3039347241 cites W2950902065 @default.
- W3039347241 cites W2951428751 @default.
- W3039347241 cites W4248107770 @default.
- W3039347241 cites W973171548 @default.
- W3039347241 doi "https://doi.org/10.1021/acsmedchemlett.0c00279" @default.
- W3039347241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7430967" @default.
- W3039347241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32832032" @default.
- W3039347241 hasPublicationYear "2020" @default.
- W3039347241 type Work @default.
- W3039347241 sameAs 3039347241 @default.
- W3039347241 citedByCount "9" @default.
- W3039347241 countsByYear W30393472412021 @default.
- W3039347241 countsByYear W30393472412022 @default.
- W3039347241 countsByYear W30393472412023 @default.
- W3039347241 crossrefType "journal-article" @default.
- W3039347241 hasAuthorship W3039347241A5017647626 @default.
- W3039347241 hasAuthorship W3039347241A5020842804 @default.
- W3039347241 hasAuthorship W3039347241A5026301472 @default.
- W3039347241 hasAuthorship W3039347241A5034364371 @default.
- W3039347241 hasAuthorship W3039347241A5046678810 @default.
- W3039347241 hasAuthorship W3039347241A5052226453 @default.
- W3039347241 hasAuthorship W3039347241A5054228857 @default.
- W3039347241 hasAuthorship W3039347241A5087947375 @default.
- W3039347241 hasBestOaLocation W30393472411 @default.
- W3039347241 hasConcept C104317684 @default.
- W3039347241 hasConcept C124320809 @default.
- W3039347241 hasConcept C182996813 @default.
- W3039347241 hasConcept C184235292 @default.
- W3039347241 hasConcept C185592680 @default.
- W3039347241 hasConcept C2777736865 @default.
- W3039347241 hasConcept C29537977 @default.
- W3039347241 hasConcept C41008148 @default.
- W3039347241 hasConcept C54174078 @default.
- W3039347241 hasConcept C55493867 @default.
- W3039347241 hasConcept C59143045 @default.
- W3039347241 hasConcept C70721500 @default.
- W3039347241 hasConcept C74187038 @default.
- W3039347241 hasConcept C82495950 @default.
- W3039347241 hasConcept C86803240 @default.
- W3039347241 hasConcept C97029542 @default.
- W3039347241 hasConceptScore W3039347241C104317684 @default.
- W3039347241 hasConceptScore W3039347241C124320809 @default.
- W3039347241 hasConceptScore W3039347241C182996813 @default.
- W3039347241 hasConceptScore W3039347241C184235292 @default.
- W3039347241 hasConceptScore W3039347241C185592680 @default.
- W3039347241 hasConceptScore W3039347241C2777736865 @default.
- W3039347241 hasConceptScore W3039347241C29537977 @default.
- W3039347241 hasConceptScore W3039347241C41008148 @default.
- W3039347241 hasConceptScore W3039347241C54174078 @default.
- W3039347241 hasConceptScore W3039347241C55493867 @default.
- W3039347241 hasConceptScore W3039347241C59143045 @default.
- W3039347241 hasConceptScore W3039347241C70721500 @default.
- W3039347241 hasConceptScore W3039347241C74187038 @default.