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- W3039382022 endingPage "602" @default.
- W3039382022 startingPage "589" @default.
- W3039382022 abstract "Inhaled lung cancer therapy is promising because of direct and noninvasive drug delivery to the lungs with low potential for severe systemic toxicity. Thus chemotherapeutic drugs have been administered clinically by nebulization of solution or suspension formulations, which demonstrated their limited pulmonary absorption and relatively mild systemic toxicity. In all these clinical trials, however, there was no obviously superior anticancer efficacy in lung cancer patients even at the maximum doses of drugs limited by pulmonary toxicity. Therefore methods that deliver both higher anticancer efficacy and lower pulmonary toxicity are strongly desired. In addition to the worldwide availability of pressured metered dose inhalers (pMDIs) and dry powder inhalers (DPIs) to treat local respiratory diseases, recent innovations in medicines and technologies are encouraging next steps toward effective inhaled lung cancer therapy with new therapeutic or drug delivery concepts. These include the discovery of target cells/molecules and drug candidates for novel cancer therapy, the development of high-performance inhalation devices for effective pulmonary drug delivery, and the establishment of manufacturing technologies for functional nanoparticles/microparticles. This review highlights the present situation and future progress of inhaled drugs for lung cancer therapy, including an overview of available inhalation devices, pharmacokinetics, and outcomes in clinical trials so far and some novel formulation strategies based on drug delivery systems to achieve enhanced anticancer efficacy and attenuated pulmonary toxicity." @default.
- W3039382022 created "2020-07-10" @default.
- W3039382022 creator A5063947325 @default.
- W3039382022 creator A5082859565 @default.
- W3039382022 date "2020-07-01" @default.
- W3039382022 modified "2023-10-14" @default.
- W3039382022 title "Present Situation and Future Progress of Inhaled Lung Cancer Therapy: Necessity of Inhaled Formulations with Drug Delivery Functions" @default.
- W3039382022 cites W1530050238 @default.
- W3039382022 cites W163900819 @default.
- W3039382022 cites W1677881169 @default.
- W3039382022 cites W1683956275 @default.
- W3039382022 cites W1743108589 @default.
- W3039382022 cites W1826768019 @default.
- W3039382022 cites W1964196183 @default.
- W3039382022 cites W1966302921 @default.
- W3039382022 cites W1966435798 @default.
- W3039382022 cites W1966580084 @default.
- W3039382022 cites W1967819079 @default.
- W3039382022 cites W1968728209 @default.
- W3039382022 cites W1969556564 @default.
- W3039382022 cites W1970942128 @default.
- W3039382022 cites W1975150426 @default.
- W3039382022 cites W1977176265 @default.
- W3039382022 cites W1981709216 @default.
- W3039382022 cites W1983222220 @default.
- W3039382022 cites W1984477495 @default.
- W3039382022 cites W1985241728 @default.
- W3039382022 cites W1985634027 @default.
- W3039382022 cites W1986410429 @default.
- W3039382022 cites W1989589605 @default.
- W3039382022 cites W1992919122 @default.
- W3039382022 cites W1997071885 @default.
- W3039382022 cites W1998445104 @default.
- W3039382022 cites W2002383654 @default.
- W3039382022 cites W2004931777 @default.
- W3039382022 cites W2007301712 @default.
- W3039382022 cites W2008299447 @default.
- W3039382022 cites W2008759459 @default.
- W3039382022 cites W2010796656 @default.
- W3039382022 cites W2015299325 @default.
- W3039382022 cites W2015934294 @default.
- W3039382022 cites W2016565975 @default.
- W3039382022 cites W2020623049 @default.
- W3039382022 cites W2024822044 @default.
- W3039382022 cites W2032739411 @default.
- W3039382022 cites W2034165978 @default.
- W3039382022 cites W2036325897 @default.
- W3039382022 cites W2042612658 @default.
- W3039382022 cites W2043768346 @default.
- W3039382022 cites W2044925494 @default.
- W3039382022 cites W2049209536 @default.
- W3039382022 cites W2049281680 @default.
- W3039382022 cites W2050730934 @default.
- W3039382022 cites W2052034310 @default.
- W3039382022 cites W2054616259 @default.
- W3039382022 cites W2055737571 @default.
- W3039382022 cites W2055750804 @default.
- W3039382022 cites W2056932561 @default.
- W3039382022 cites W2058889783 @default.
- W3039382022 cites W2062181861 @default.
- W3039382022 cites W2063435055 @default.
- W3039382022 cites W2063601146 @default.
- W3039382022 cites W2064499831 @default.
- W3039382022 cites W2068616022 @default.
- W3039382022 cites W2070362125 @default.
- W3039382022 cites W2075003434 @default.
- W3039382022 cites W2075527551 @default.
- W3039382022 cites W2076476870 @default.
- W3039382022 cites W2077722212 @default.
- W3039382022 cites W2082604088 @default.
- W3039382022 cites W2088603650 @default.
- W3039382022 cites W2088659772 @default.
- W3039382022 cites W2089648906 @default.
- W3039382022 cites W2089669803 @default.
- W3039382022 cites W2091173330 @default.
- W3039382022 cites W2092482435 @default.
- W3039382022 cites W2093312070 @default.
- W3039382022 cites W2093940404 @default.
- W3039382022 cites W2098776311 @default.
- W3039382022 cites W2105393448 @default.
- W3039382022 cites W2105395122 @default.
- W3039382022 cites W2110471088 @default.
- W3039382022 cites W2112679976 @default.
- W3039382022 cites W2121421664 @default.
- W3039382022 cites W2124140010 @default.
- W3039382022 cites W2124596793 @default.
- W3039382022 cites W2127344848 @default.
- W3039382022 cites W2127654256 @default.
- W3039382022 cites W2140989670 @default.
- W3039382022 cites W2141533074 @default.
- W3039382022 cites W2144779713 @default.
- W3039382022 cites W2149974395 @default.
- W3039382022 cites W2151329903 @default.
- W3039382022 cites W2152782396 @default.
- W3039382022 cites W2153207740 @default.
- W3039382022 cites W2155062388 @default.
- W3039382022 cites W2160027607 @default.
- W3039382022 cites W2165188539 @default.