Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039386892> ?p ?o ?g. }
- W3039386892 abstract "S ummary Mammalian genomes contain long domains with distinct average compositions of A/T versus G/C base pairs. In a screen for proteins that might interpret base composition by binding to AT-rich motifs, we identified the stem cell factor SALL4 which contains multiple zinc-fingers. Mutation of the domain responsible for AT binding drastically reduced SALL4 genome occupancy and prematurely up-regulated genes in proportion to their AT content. Inactivation of this single AT-binding zinc-finger cluster mimicked defects seen in Sall4 -null cells, including precocious differentiation of embryonic stem cells and embryonic lethality in mice. In contrast, deletion of two other zinc-finger clusters was phenotypically neutral. Our data indicate that loss of pluripotency is triggered by down-regulation of SALL4, leading to de-repression of a set of AT-rich genes that promotes neuronal differentiation. We conclude that base composition is not merely a passive by-product of genome evolution, but constitutes a signal that aids control of cell fate." @default.
- W3039386892 created "2020-07-10" @default.
- W3039386892 creator A5011106347 @default.
- W3039386892 creator A5011960591 @default.
- W3039386892 creator A5020181431 @default.
- W3039386892 creator A5024599083 @default.
- W3039386892 creator A5028751448 @default.
- W3039386892 creator A5044816611 @default.
- W3039386892 creator A5048594051 @default.
- W3039386892 creator A5050687411 @default.
- W3039386892 creator A5053952380 @default.
- W3039386892 creator A5059576154 @default.
- W3039386892 creator A5073346894 @default.
- W3039386892 creator A5078036095 @default.
- W3039386892 creator A5084077265 @default.
- W3039386892 date "2020-07-01" @default.
- W3039386892 modified "2023-09-28" @default.
- W3039386892 title "SALL4 controls cell fate in response to DNA base composition" @default.
- W3039386892 cites W1510523291 @default.
- W3039386892 cites W1525573602 @default.
- W3039386892 cites W1570257026 @default.
- W3039386892 cites W1665729359 @default.
- W3039386892 cites W1967269362 @default.
- W3039386892 cites W1968962291 @default.
- W3039386892 cites W1973672022 @default.
- W3039386892 cites W1977709885 @default.
- W3039386892 cites W1986689815 @default.
- W3039386892 cites W1987333766 @default.
- W3039386892 cites W1987513180 @default.
- W3039386892 cites W1989000599 @default.
- W3039386892 cites W1989550427 @default.
- W3039386892 cites W1994453710 @default.
- W3039386892 cites W2001442967 @default.
- W3039386892 cites W2002566405 @default.
- W3039386892 cites W2003236418 @default.
- W3039386892 cites W2004776010 @default.
- W3039386892 cites W2009025045 @default.
- W3039386892 cites W2009166526 @default.
- W3039386892 cites W2009677247 @default.
- W3039386892 cites W2010291571 @default.
- W3039386892 cites W2012763636 @default.
- W3039386892 cites W2018604728 @default.
- W3039386892 cites W2020159234 @default.
- W3039386892 cites W2024800238 @default.
- W3039386892 cites W2028051736 @default.
- W3039386892 cites W2030948026 @default.
- W3039386892 cites W2035618305 @default.
- W3039386892 cites W2053700159 @default.
- W3039386892 cites W2055597783 @default.
- W3039386892 cites W2055852018 @default.
- W3039386892 cites W2055924676 @default.
- W3039386892 cites W2056783276 @default.
- W3039386892 cites W2057322816 @default.
- W3039386892 cites W2058521801 @default.
- W3039386892 cites W2065128082 @default.
- W3039386892 cites W2066483052 @default.
- W3039386892 cites W2070030982 @default.
- W3039386892 cites W2074380974 @default.
- W3039386892 cites W2080116079 @default.
- W3039386892 cites W2080752012 @default.
- W3039386892 cites W2083487263 @default.
- W3039386892 cites W2084090304 @default.
- W3039386892 cites W2084118479 @default.
- W3039386892 cites W2091459202 @default.
- W3039386892 cites W2092464006 @default.
- W3039386892 cites W2092920480 @default.
- W3039386892 cites W2095111355 @default.
- W3039386892 cites W2096532391 @default.
- W3039386892 cites W2102619694 @default.
- W3039386892 cites W2110251865 @default.
- W3039386892 cites W2114951390 @default.
- W3039386892 cites W2118916005 @default.
- W3039386892 cites W2122638939 @default.
- W3039386892 cites W2124514674 @default.
- W3039386892 cites W2127455821 @default.
- W3039386892 cites W2131271579 @default.
- W3039386892 cites W2152121035 @default.
- W3039386892 cites W2153771353 @default.
- W3039386892 cites W2157458089 @default.
- W3039386892 cites W2157952888 @default.
- W3039386892 cites W2158771952 @default.
- W3039386892 cites W2158789637 @default.
- W3039386892 cites W2160352834 @default.
- W3039386892 cites W2164419770 @default.
- W3039386892 cites W2167319920 @default.
- W3039386892 cites W2170314963 @default.
- W3039386892 cites W2170964754 @default.
- W3039386892 cites W2171808845 @default.
- W3039386892 cites W2179438025 @default.
- W3039386892 cites W2267877430 @default.
- W3039386892 cites W2412835885 @default.
- W3039386892 cites W2463195069 @default.
- W3039386892 cites W2501554892 @default.
- W3039386892 cites W2507306980 @default.
- W3039386892 cites W2554550365 @default.
- W3039386892 cites W2565494381 @default.
- W3039386892 cites W2573731673 @default.
- W3039386892 cites W2586326639 @default.
- W3039386892 cites W2753202871 @default.
- W3039386892 cites W2886283685 @default.