FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039403455> ?p ?o ?g. }

• W3039403455 abstract "Abstract Background Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset and recurrent, severe episodes or a chronic course with poor psychosocial functioning in a proportion of patients. Many patients with BD experience substantial symptomatology months or even years before full BD manifestation. Adequate diagnosis and treatment is often delayed, which is associated with a worse outcome. This study aims to prospectively evaluate and improve early recognition and intervention strategies for persons at-risk for BD. Methods Early-BipoLife is a prospective-longitudinal cohort study of 1419 participants (aged 15–35 years) with at least five waves of assessment over a period of at least 2 years (baseline, 6, 12, 18 and 24 months). A research consortium of ten university and teaching hospitals across Germany conducts this study. The following risk groups (RGs) were recruited: RG I: help-seeking youth and young adults consulting early recognition centres/facilities presenting ≥ 1 of the proposed risk factors for BD, RG II: in-/outpatients with unipolar depressive syndrome, and RG III: in-/outpatients with attention-deficit/hyperactivity disorder (ADHD). The reference cohort was selected from the German representative IMAGEN cohort. Over the study period, the natural course of risk and resilience factors, early symptoms of BD and changes of symptom severity (including conversion to manifest BD) are observed. Psychometric properties of recently developed, structured instruments on potential risk factors for conversion to BD and subsyndromal symptomatology (Bipolar Prodrome Symptom Scale, Bipolar at-risk criteria, EPI bipolar ) and biomarkers that potentially improve prediction are investigated. Moreover, actual treatment recommendations are monitored in the participating specialized services and compared to recently postulated clinical categorization and treatment guidance in the field of early BD. Discussion Findings from this study will contribute to an improved knowledge about the natural course of BD, from the onset of first noticeable symptoms (precursors) to fully developed BD, and about mechanisms of conversion from subthreshold to manifest BD. Moreover, these generated data will provide information for the development of evidence-based guidelines for early-targeted detection and preventive intervention for people at risk for BD." @default.
• W3039403455 created "2020-07-10" @default.
• W3039403455 creator A5005954499 @default.
• W3039403455 creator A5006780095 @default.
• W3039403455 creator A5007537656 @default.
• W3039403455 creator A5010852646 @default.
• W3039403455 creator A5022013485 @default.
• W3039403455 creator A5027556916 @default.
• W3039403455 creator A5036153586 @default.
• W3039403455 creator A5041397944 @default.
• W3039403455 creator A5042491419 @default.
• W3039403455 creator A5052199719 @default.
• W3039403455 creator A5052673298 @default.
• W3039403455 creator A5056944189 @default.
• W3039403455 creator A5057711679 @default.
• W3039403455 creator A5059967833 @default.
• W3039403455 creator A5063823796 @default.
• W3039403455 creator A5067269418 @default.
• W3039403455 creator A5071728849 @default.
• W3039403455 creator A5072564468 @default.
• W3039403455 creator A5073090214 @default.
• W3039403455 creator A5077655064 @default.
• W3039403455 creator A5079874777 @default.
• W3039403455 creator A5089666136 @default.
• W3039403455 date "2020-07-01" @default.
• W3039403455 modified "2023-10-03" @default.
• W3039403455 title "Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife)" @default.
• W3039403455 cites W116668670 @default.
• W3039403455 cites W143843505 @default.
• W3039403455 cites W1594114024 @default.
• W3039403455 cites W1604629503 @default.
• W3039403455 cites W1879988696 @default.
• W3039403455 cites W1913323837 @default.
• W3039403455 cites W1938273588 @default.
• W3039403455 cites W1958934871 @default.
• W3039403455 cites W1959544975 @default.
• W3039403455 cites W1963897326 @default.
• W3039403455 cites W1966411707 @default.
• W3039403455 cites W1969490649 @default.
• W3039403455 cites W1969679828 @default.
• W3039403455 cites W1979258014 @default.
• W3039403455 cites W1981803616 @default.
• W3039403455 cites W1983960867 @default.
• W3039403455 cites W1985129141 @default.
• W3039403455 cites W1985689469 @default.
• W3039403455 cites W1986275520 @default.
• W3039403455 cites W1987928276 @default.
• W3039403455 cites W1990043440 @default.
• W3039403455 cites W2010677545 @default.
• W3039403455 cites W2011003381 @default.
• W3039403455 cites W2011709753 @default.
• W3039403455 cites W2018131844 @default.
• W3039403455 cites W2023311435 @default.
• W3039403455 cites W2023731405 @default.
• W3039403455 cites W2024947622 @default.
• W3039403455 cites W2026834521 @default.
• W3039403455 cites W2028336126 @default.
• W3039403455 cites W2038363427 @default.
• W3039403455 cites W2038821609 @default.
• W3039403455 cites W2046492864 @default.
• W3039403455 cites W2047147474 @default.
• W3039403455 cites W2049867826 @default.
• W3039403455 cites W2057194742 @default.
• W3039403455 cites W2059256690 @default.
• W3039403455 cites W2078774097 @default.
• W3039403455 cites W2082085369 @default.
• W3039403455 cites W2083312379 @default.
• W3039403455 cites W2088502642 @default.
• W3039403455 cites W2088913489 @default.
• W3039403455 cites W2089160234 @default.
• W3039403455 cites W2096948995 @default.
• W3039403455 cites W2101209751 @default.
• W3039403455 cites W2104807599 @default.
• W3039403455 cites W2108080286 @default.
• W3039403455 cites W2109010008 @default.
• W3039403455 cites W2113568573 @default.
• W3039403455 cites W2115558364 @default.
• W3039403455 cites W2117023943 @default.
• W3039403455 cites W2119225029 @default.
• W3039403455 cites W2119325457 @default.
• W3039403455 cites W2120670471 @default.
• W3039403455 cites W2123436465 @default.
• W3039403455 cites W2124435984 @default.
• W3039403455 cites W2130766477 @default.
• W3039403455 cites W2132476041 @default.
• W3039403455 cites W2133752646 @default.
• W3039403455 cites W2134670478 @default.
• W3039403455 cites W2138107058 @default.
• W3039403455 cites W2140589869 @default.
• W3039403455 cites W2143644129 @default.
• W3039403455 cites W2151193184 @default.
• W3039403455 cites W2158521887 @default.
• W3039403455 cites W2167209772 @default.
• W3039403455 cites W2169411569 @default.
• W3039403455 cites W2170372220 @default.
• W3039403455 cites W2209358680 @default.
• W3039403455 cites W2235745041 @default.
• W3039403455 cites W2311058692 @default.
• W3039403455 cites W2409240063 @default.
• W3039403455 cites W2496143505 @default.

• next