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- W3039427359 abstract "Autonomous rodent protoparvoviruses (PVs) are promising anticancer agents due to their excellent safety profile, natural oncotropism, and oncosuppressive activities. Viral infection can trigger immunogenic cell death, activating the immune system against the tumor. However, the efficacy of this treatment in recent clinical trials is moderate compared with results seen in preclinical work. Various strategies have been employed to improve the anticancer activities of oncolytic PVs, including development of second-generation parvoviruses with enhanced oncolytic and immunostimulatory activities and rational combination of PVs with other therapies. Understanding the cellular factors involved in the PV life cycle is another important area of investigation. Indeed, these studies may lead to the identification of biomarkers that would allow a more personalized use of PV-based therapies. This review focuses on this work and the challenges that still need to be overcome to move PVs forward into clinical practice as an effective therapeutic option for cancer patients." @default.
- W3039427359 created "2020-07-10" @default.
- W3039427359 creator A5017217643 @default.
- W3039427359 creator A5018068390 @default.
- W3039427359 creator A5063476387 @default.
- W3039427359 creator A5081121646 @default.
- W3039427359 date "2020-09-29" @default.
- W3039427359 modified "2023-10-18" @default.
- W3039427359 title "A Roadmap for the Success of Oncolytic Parvovirus-Based Anticancer Therapies" @default.
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