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- W3039431119 abstract "In cancer, suppression of protein phosphatases, such as protein phosphatase 2A (PP2A), that normally counteract kinases, contributes to aberrant signaling. Leonard et al. recently demonstrated that a novel small-molecule activator of PP2A, DT-061, selectively stabilizes a specific PP2A holoenzyme responsible for dephosphorylating critical oncogenic targets, including MYC. The 3.6-A cryo-electron microscopy map of the heterotrimer assembly provides insight into the druggable structure of PP2A, guiding future phosphatase therapeutics." @default.
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- W3039431119 date "2020-09-01" @default.
- W3039431119 modified "2023-10-02" @default.
- W3039431119 title "Select Stabilization of a Tumor-Suppressive PP2A Heterotrimer" @default.
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- W3039431119 doi "https://doi.org/10.1016/j.tips.2020.06.008" @default.
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