FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039449583> ?p ?o ?g. }

• W3039449583 abstract "ABSTRACT Background The bioactive metabolites production contributes to the resistance of fungi towards adverse environmental conditions. Some metabolites often have interesting health-promoting activities. This study addressed the anti-tumoural properties of Penicillium purpurogenum isolated from a polluted lagoon in Northeastern Brazil. Methods The extract obtained from the polished environment strain P. purpurogenum was fermented, filtered, concentrated and lyophilized, giving rise to the Ethyl Acetate Extracellular Extract (EAE). The metabolites of the extracellular extract of P. purpurogenum were studied using direct infusion mass spectrometry. The solid Ehrlic tumor model was used to evaluate the extract antitumor activity. Female Swiss mice were divided in groups (n=10/group) as follow: Negative control (CTL-) treated with phosphate buffered solution; Positive Control (CTL+) treated with cyclophosphamide (25mg/mL); Extracts treatment at doses 4, 20 and 100mg/Kg; Animals without tumor or treatment (Sham); and animals without tumor treated with intermediate dose (EAE20). All treatments were performed intraperitoneally, daily during 15 days. After, the animals were eutanized and the tumor, lymphoid organs and serum were used for immunological, histological and biochemical parameters evaluation. Results The extract was rich in meroterpenoids. All doses of the extract significantly reduced tumor size compared to CLT- and were associated with 100% survival. Histologically, the 20 and 100mg/kg doses reduced tumour-associated inflammation and tumour necrosis. The extract also reduced cellular infiltration of lymphoid organs and circulating TNF-α levels when compared with CLT-. The extract did not induce weight loss and renal or hepatic toxic changes. Conclusions These results indicate that P. purpurogenum from a polluted marine environment produce hybrid natural products of the terpenoid pathway that exhibits immunomodulatory and antitumor properties in vivo . Thus, fungal fermentation is a biotechnological approach for the production of antitumour agents." @default.
• W3039449583 created "2020-07-10" @default.
• W3039449583 creator A5004864639 @default.
• W3039449583 creator A5011590333 @default.
• W3039449583 creator A5013511462 @default.
• W3039449583 creator A5015636954 @default.
• W3039449583 creator A5020331899 @default.
• W3039449583 creator A5038704332 @default.
• W3039449583 creator A5039316458 @default.
• W3039449583 creator A5044964742 @default.
• W3039449583 creator A5053545794 @default.
• W3039449583 creator A5061671111 @default.
• W3039449583 creator A5062286192 @default.
• W3039449583 creator A5065071420 @default.
• W3039449583 creator A5081249489 @default.
• W3039449583 date "2020-07-02" @default.
• W3039449583 modified "2023-10-01" @default.
• W3039449583 title "Penicillium purpurogenum exerts antitumor effects and ameliorates inflammations in Erlich mice model" @default.
• W3039449583 cites W1599978992 @default.
• W3039449583 cites W1627786998 @default.
• W3039449583 cites W1964168757 @default.
• W3039449583 cites W1970206930 @default.
• W3039449583 cites W1980498264 @default.
• W3039449583 cites W1994432921 @default.
• W3039449583 cites W2004798169 @default.
• W3039449583 cites W2020606724 @default.
• W3039449583 cites W2020873812 @default.
• W3039449583 cites W2021912805 @default.
• W3039449583 cites W2023360367 @default.
• W3039449583 cites W2029997716 @default.
• W3039449583 cites W2035158433 @default.
• W3039449583 cites W2056357003 @default.
• W3039449583 cites W2074296318 @default.
• W3039449583 cites W2108616612 @default.
• W3039449583 cites W2114579415 @default.
• W3039449583 cites W2116283917 @default.
• W3039449583 cites W2132870387 @default.
• W3039449583 cites W2171644284 @default.
• W3039449583 cites W2319254461 @default.
• W3039449583 cites W2339031801 @default.
• W3039449583 cites W2437248532 @default.
• W3039449583 cites W2462228245 @default.
• W3039449583 cites W2556968169 @default.
• W3039449583 cites W2560578126 @default.
• W3039449583 cites W2575715638 @default.
• W3039449583 cites W2587251743 @default.
• W3039449583 cites W2594069356 @default.
• W3039449583 cites W2617782212 @default.
• W3039449583 cites W2621398346 @default.
• W3039449583 cites W2752108244 @default.
• W3039449583 cites W2754888878 @default.
• W3039449583 cites W2756370341 @default.
• W3039449583 cites W2810052683 @default.
• W3039449583 cites W2843717716 @default.
• W3039449583 cites W2868066886 @default.
• W3039449583 cites W2889300460 @default.
• W3039449583 cites W2889646458 @default.
• W3039449583 cites W2890201446 @default.
• W3039449583 cites W2908985181 @default.
• W3039449583 cites W2958959267 @default.
• W3039449583 cites W2982709819 @default.
• W3039449583 cites W3009100563 @default.
• W3039449583 cites W3016171372 @default.
• W3039449583 cites W4213216846 @default.
• W3039449583 cites W4232974758 @default.
• W3039449583 doi "https://doi.org/10.1101/2020.07.02.184291" @default.
• W3039449583 hasPublicationYear "2020" @default.
• W3039449583 type Work @default.
• W3039449583 sameAs 3039449583 @default.
• W3039449583 citedByCount "0" @default.
• W3039449583 crossrefType "posted-content" @default.
• W3039449583 hasAuthorship W3039449583A5004864639 @default.
• W3039449583 hasAuthorship W3039449583A5011590333 @default.
• W3039449583 hasAuthorship W3039449583A5013511462 @default.
• W3039449583 hasAuthorship W3039449583A5015636954 @default.
• W3039449583 hasAuthorship W3039449583A5020331899 @default.
• W3039449583 hasAuthorship W3039449583A5038704332 @default.
• W3039449583 hasAuthorship W3039449583A5039316458 @default.
• W3039449583 hasAuthorship W3039449583A5044964742 @default.
• W3039449583 hasAuthorship W3039449583A5053545794 @default.
• W3039449583 hasAuthorship W3039449583A5061671111 @default.
• W3039449583 hasAuthorship W3039449583A5062286192 @default.
• W3039449583 hasAuthorship W3039449583A5065071420 @default.
• W3039449583 hasAuthorship W3039449583A5081249489 @default.
• W3039449583 hasBestOaLocation W30394495831 @default.
• W3039449583 hasConcept C121332964 @default.
• W3039449583 hasConcept C126322002 @default.
• W3039449583 hasConcept C153400128 @default.
• W3039449583 hasConcept C17991360 @default.
• W3039449583 hasConcept C185592680 @default.
• W3039449583 hasConcept C203014093 @default.
• W3039449583 hasConcept C2776694085 @default.
• W3039449583 hasConcept C2776755627 @default.
• W3039449583 hasConcept C2780931953 @default.
• W3039449583 hasConcept C28406088 @default.
• W3039449583 hasConcept C55493867 @default.
• W3039449583 hasConcept C71924100 @default.
• W3039449583 hasConcept C86803240 @default.
• W3039449583 hasConcept C97355855 @default.
• W3039449583 hasConcept C98274493 @default.

• next