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• W3039478115 endingPage "1588" @default.
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• W3039478115 abstract "Stress causes symptom exacerbation in functional disorders of the urinary bladder. However, the potential mediators and underlying mechanisms of stress effects on micturition reflex function are unknown. We have characterized PACAP (Adcyap1) and PAC1 receptor (Adcyap1r1) signaling in stress-induced urinary bladder dysfunction in mice. We determined PACAP and PAC1 transcripts and protein expressions in the urinary bladder and lumbosacral dorsal root ganglia (DRG) and spinal cord in repeated variate stress (RVS) or control mouse (handling only) groups. RVS in mice significantly (p ≤ 0.01) increased serum corticosterone and urinary bladder NGF content and decreased weight gain. PACAP and PAC1 mRNA and protein were differentially regulated in lower urinary tract tissues with changes observed in lumbosacral DRG and spinal cord but not in urinary bladder. RVS exposure in mice significantly (p ≤ 0.01) increased (2.5-fold) voiding frequency as determined using conscious cystometry. Intrabladder administration of the PAC1 receptor antagonist, PACAP(6-38) (300 nM), significantly (p ≤ 0.01) increased infused volume (1.5-2.7-fold) to elicit a micturition event and increased the intercontraction interval (i.e., decreased voiding frequency) in mice exposed to RVS and in control mice, but changes were smaller in magnitude in control mice. We also evaluated the effect of PAC1 blockade at the level of the urinary bladder on pelvic sensitivity in RVS or control mouse groups using von Frey filament testing. Intrabladder administration of PACAP(6-38) (300 nM) significantly (p ≤ 0.01) reduced pelvic sensitivity following RVS. PACAP/receptor signaling in the CNS and PNS contributes to increased voiding frequency and pelvic sensitivity following RVS and may represent a potential target for therapeutic intervention." @default.
• W3039478115 created "2020-07-10" @default.
• W3039478115 creator A5002575953 @default.
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• W3039478115 date "2020-07-01" @default.
• W3039478115 modified "2023-10-15" @default.
• W3039478115 title "Intrabladder PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in Mice Exposed to Repeated Variate Stress (RVS)" @default.
• W3039478115 cites W1503681492 @default.
• W3039478115 cites W1763102409 @default.
• W3039478115 cites W1943803896 @default.
• W3039478115 cites W1961069803 @default.
• W3039478115 cites W1967643044 @default.
• W3039478115 cites W1968309695 @default.
• W3039478115 cites W1969138434 @default.
• W3039478115 cites W1969446471 @default.
• W3039478115 cites W1971284716 @default.
• W3039478115 cites W1971947927 @default.
• W3039478115 cites W1975486846 @default.
• W3039478115 cites W1975765156 @default.
• W3039478115 cites W1976403587 @default.
• W3039478115 cites W1980113161 @default.
• W3039478115 cites W1980649916 @default.
• W3039478115 cites W1982315004 @default.
• W3039478115 cites W1983496212 @default.
• W3039478115 cites W1983600193 @default.
• W3039478115 cites W1987422111 @default.
• W3039478115 cites W1989334840 @default.
• W3039478115 cites W1992723041 @default.
• W3039478115 cites W1995826005 @default.
• W3039478115 cites W1996091038 @default.
• W3039478115 cites W1996128733 @default.
• W3039478115 cites W2003024942 @default.
• W3039478115 cites W2004930473 @default.
• W3039478115 cites W2013488690 @default.
• W3039478115 cites W2016654953 @default.
• W3039478115 cites W2020428801 @default.
• W3039478115 cites W2021981193 @default.
• W3039478115 cites W2024876386 @default.
• W3039478115 cites W2031099784 @default.
• W3039478115 cites W2045650131 @default.
• W3039478115 cites W2047523044 @default.
• W3039478115 cites W2053241556 @default.
• W3039478115 cites W2054860352 @default.
• W3039478115 cites W2056794468 @default.
• W3039478115 cites W2057018679 @default.
• W3039478115 cites W2058771734 @default.
• W3039478115 cites W2066320273 @default.
• W3039478115 cites W2068146214 @default.
• W3039478115 cites W2072901766 @default.
• W3039478115 cites W2073110610 @default.
• W3039478115 cites W2073676810 @default.
• W3039478115 cites W2075424733 @default.
• W3039478115 cites W2080249698 @default.
• W3039478115 cites W2082155672 @default.
• W3039478115 cites W2082327161 @default.
• W3039478115 cites W2085428036 @default.
• W3039478115 cites W2085898792 @default.
• W3039478115 cites W2087353002 @default.
• W3039478115 cites W2091854576 @default.
• W3039478115 cites W2092980860 @default.
• W3039478115 cites W2098117013 @default.
• W3039478115 cites W2105363367 @default.
• W3039478115 cites W2105588815 @default.
• W3039478115 cites W2105720373 @default.
• W3039478115 cites W2106949446 @default.
• W3039478115 cites W2109358424 @default.
• W3039478115 cites W2111058306 @default.
• W3039478115 cites W2111407966 @default.
• W3039478115 cites W2119799442 @default.
• W3039478115 cites W2123865806 @default.
• W3039478115 cites W2124776014 @default.
• W3039478115 cites W2124950240 @default.
• W3039478115 cites W2127053354 @default.
• W3039478115 cites W2131166849 @default.
• W3039478115 cites W2135271875 @default.
• W3039478115 cites W2136800716 @default.
• W3039478115 cites W2142393381 @default.
• W3039478115 cites W2143589064 @default.
• W3039478115 cites W2144400722 @default.
• W3039478115 cites W2157766864 @default.
• W3039478115 cites W2161647215 @default.
• W3039478115 cites W2163110107 @default.
• W3039478115 cites W2165709961 @default.
• W3039478115 cites W2168704375 @default.
• W3039478115 cites W2170312314 @default.
• W3039478115 cites W2329393689 @default.
• W3039478115 cites W2345351513 @default.
• W3039478115 cites W2357264154 @default.
• W3039478115 cites W2512786904 @default.
• W3039478115 cites W2527741586 @default.
• W3039478115 cites W2626370384 @default.
• W3039478115 cites W2772666645 @default.
• W3039478115 cites W2778279333 @default.

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