FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039486665> ?p ?o ?g. }

• W3039486665 endingPage "559" @default.
• W3039486665 startingPage "549" @default.
• W3039486665 abstract "OBJECTIVE: Studies have suggested that miR-21-5p and WWC2 are key players in most cancer types, yet the underlying mechanisms in lung adenocarcinoma (LUAD) remain elusive. This study made in-depth research on the two factors-dependent mechanisms underlying LUAD occurrence and development. METHODS: Bioinformatics methods were employed to identify the miRNA and its target gene of interest. In all, 20 pairs of LUAD tumor tissue samples and matched adjacent normal samples along with 5 LUAD cell lines were collected for evaluating the aberrant expression of miR-21-5p and WWC2. Dual-luciferase reporter assay was performed to validate the targeted relationship between miR-21-5p and WWC2. A series of in vitro experiments including colony formation assay, EdU, wound healing assay and Transwell were conducted for assessment of the LUAD cell biological behaviors. In addition, Western blot was carried out to determine the protein expression of epithelial-mesenchymal transition (EMT)-related proteins. RESULTS: miR-21-5p was found to be considerably increased in LUAD tissue and cells relative to that in the adjacent tissue and the human bronchial epithelial cells, whereas WWC2 was significantly decreased. Dual-luciferase reporter assay revealed that miR-21-5p targeted WWC2 and down-regulated its expression. Besides, silencing miR-21-5p or overexpressing WWC2 played an inhibitory role in PC-9 cancer cell proliferation, migration and invasion, but such effect was suppressed when miR-21-5p was overexpressed. Furthermore, Western blot uncovered that WWC2 overexpression impeded the EMT process in LUAD cells. CONCLUSION: miR-21-5p facilitates LUAD cell proliferation, migration and invasion through targeting WWC2, which provides a novel therapeutic target for LUAD treatment." @default.
• W3039486665 created "2020-07-10" @default.
• W3039486665 creator A5000799549 @default.
• W3039486665 creator A5020794198 @default.
• W3039486665 creator A5032815771 @default.
• W3039486665 creator A5046900031 @default.
• W3039486665 creator A5060471072 @default.
• W3039486665 creator A5082930059 @default.
• W3039486665 creator A5084288880 @default.
• W3039486665 date "2020-08-03" @default.
• W3039486665 modified "2023-09-29" @default.
• W3039486665 title "miR-21-5p promotes lung adenocarcinoma cell proliferation, migration and invasion via targeting WWC2" @default.
• W3039486665 cites W1051643313 @default.
• W3039486665 cites W1551999069 @default.
• W3039486665 cites W1757407923 @default.
• W3039486665 cites W1994548165 @default.
• W3039486665 cites W2032093760 @default.
• W3039486665 cites W2042044023 @default.
• W3039486665 cites W2056631765 @default.
• W3039486665 cites W2066505201 @default.
• W3039486665 cites W2096439249 @default.
• W3039486665 cites W2100393058 @default.
• W3039486665 cites W2118019849 @default.
• W3039486665 cites W2132264180 @default.
• W3039486665 cites W2136876543 @default.
• W3039486665 cites W2139979194 @default.
• W3039486665 cites W2272984102 @default.
• W3039486665 cites W2295032943 @default.
• W3039486665 cites W2316248694 @default.
• W3039486665 cites W2324080174 @default.
• W3039486665 cites W2333972433 @default.
• W3039486665 cites W2409066095 @default.
• W3039486665 cites W2466033276 @default.
• W3039486665 cites W2516581903 @default.
• W3039486665 cites W2604974376 @default.
• W3039486665 cites W2612818445 @default.
• W3039486665 cites W2743647926 @default.
• W3039486665 cites W2746461215 @default.
• W3039486665 cites W2766763414 @default.
• W3039486665 cites W2767656535 @default.
• W3039486665 cites W2783374245 @default.
• W3039486665 cites W2790831960 @default.
• W3039486665 cites W2804027477 @default.
• W3039486665 cites W2903106403 @default.
• W3039486665 cites W2949921751 @default.
• W3039486665 cites W2974899097 @default.
• W3039486665 cites W4206673553 @default.
• W3039486665 cites W4210982799 @default.
• W3039486665 doi "https://doi.org/10.3233/cbm-201489" @default.
• W3039486665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32623387" @default.
• W3039486665 hasPublicationYear "2020" @default.
• W3039486665 type Work @default.
• W3039486665 sameAs 3039486665 @default.
• W3039486665 citedByCount "19" @default.
• W3039486665 countsByYear W30394866652020 @default.
• W3039486665 countsByYear W30394866652021 @default.
• W3039486665 countsByYear W30394866652022 @default.
• W3039486665 countsByYear W30394866652023 @default.
• W3039486665 crossrefType "journal-article" @default.
• W3039486665 hasAuthorship W3039486665A5000799549 @default.
• W3039486665 hasAuthorship W3039486665A5020794198 @default.
• W3039486665 hasAuthorship W3039486665A5032815771 @default.
• W3039486665 hasAuthorship W3039486665A5046900031 @default.
• W3039486665 hasAuthorship W3039486665A5060471072 @default.
• W3039486665 hasAuthorship W3039486665A5082930059 @default.
• W3039486665 hasAuthorship W3039486665A5084288880 @default.
• W3039486665 hasConcept C104317684 @default.
• W3039486665 hasConcept C111335760 @default.
• W3039486665 hasConcept C119056186 @default.
• W3039486665 hasConcept C11957725 @default.
• W3039486665 hasConcept C121608353 @default.
• W3039486665 hasConcept C137738243 @default.
• W3039486665 hasConcept C142724271 @default.
• W3039486665 hasConcept C145059251 @default.
• W3039486665 hasConcept C1491633281 @default.
• W3039486665 hasConcept C150194340 @default.
• W3039486665 hasConcept C153911025 @default.
• W3039486665 hasConcept C161733203 @default.
• W3039486665 hasConcept C203014093 @default.
• W3039486665 hasConcept C2776256026 @default.
• W3039486665 hasConcept C2776415932 @default.
• W3039486665 hasConcept C2779013556 @default.
• W3039486665 hasConcept C2780269544 @default.
• W3039486665 hasConcept C2781182431 @default.
• W3039486665 hasConcept C502942594 @default.
• W3039486665 hasConcept C54009773 @default.
• W3039486665 hasConcept C54355233 @default.
• W3039486665 hasConcept C62112901 @default.
• W3039486665 hasConcept C71924100 @default.
• W3039486665 hasConcept C76419328 @default.
• W3039486665 hasConcept C81885089 @default.
• W3039486665 hasConcept C86803240 @default.
• W3039486665 hasConceptScore W3039486665C104317684 @default.
• W3039486665 hasConceptScore W3039486665C111335760 @default.
• W3039486665 hasConceptScore W3039486665C119056186 @default.
• W3039486665 hasConceptScore W3039486665C11957725 @default.
• W3039486665 hasConceptScore W3039486665C121608353 @default.
• W3039486665 hasConceptScore W3039486665C137738243 @default.

• next