Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039488799> ?p ?o ?g. }
- W3039488799 endingPage "167" @default.
- W3039488799 startingPage "158" @default.
- W3039488799 abstract "Abstract Excess cobalt may lead to metallosis, characterized by sensorineural hearing loss, visual, and cognitive impairment, and peripheral neuropathy. In the present study, we sought to address the molecular mechanisms of cobalt-induced neurotoxicity, using Caenorhabditis elegans as an experimental model. Exposure to cobalt chloride for 2 h significantly decreased the survival rate and lifespan in nematodes. Cobalt chloride exposure led to increased oxidative stress and upregulation of glutathione S-transferase 4. Consistently, its upstream regulator skn-1, a mammalian homolog of the nuclear factor erythroid 2-related factor 2, was activated. Among the mRNAs examined by quantitative real-time polymerase chain reactions, apoptotic activator egl-1, proapoptotic gene ced-9, autophagic (bec-1 and lgg-1), and mitochondrial fission regulator drp-1 were significantly upregulated upon cobalt exposure, concomitant with mitochondrial fragmentation, as determined by confocal microscopy. Moreover, drp-1 inhibition suppressed the cobalt chloride-induced reactive oxygen species generation, growth defects, and reduced mitochondrial fragmentation. Our novel findings suggest that the acute toxicity of cobalt is mediated by mitochondrial fragmentation and drp-1 upregulation." @default.
- W3039488799 created "2020-07-10" @default.
- W3039488799 creator A5014582487 @default.
- W3039488799 creator A5035503566 @default.
- W3039488799 creator A5045876312 @default.
- W3039488799 creator A5072815126 @default.
- W3039488799 date "2020-06-10" @default.
- W3039488799 modified "2023-10-12" @default.
- W3039488799 title "Drp-1-Dependent Mitochondrial Fragmentation Contributes to Cobalt Chloride-Induced Toxicity in Caenorhabditis elegans" @default.
- W3039488799 cites W1104977322 @default.
- W3039488799 cites W1514640681 @default.
- W3039488799 cites W1548631381 @default.
- W3039488799 cites W1765741204 @default.
- W3039488799 cites W1926228770 @default.
- W3039488799 cites W1944127002 @default.
- W3039488799 cites W1973127599 @default.
- W3039488799 cites W1997554636 @default.
- W3039488799 cites W2002830783 @default.
- W3039488799 cites W2006696253 @default.
- W3039488799 cites W2044911918 @default.
- W3039488799 cites W2065721484 @default.
- W3039488799 cites W2077826769 @default.
- W3039488799 cites W2080321548 @default.
- W3039488799 cites W2084034472 @default.
- W3039488799 cites W2087212218 @default.
- W3039488799 cites W2096297372 @default.
- W3039488799 cites W2107277218 @default.
- W3039488799 cites W2120473107 @default.
- W3039488799 cites W2125459676 @default.
- W3039488799 cites W2135138213 @default.
- W3039488799 cites W2140152944 @default.
- W3039488799 cites W2148071816 @default.
- W3039488799 cites W2160913295 @default.
- W3039488799 cites W2167279371 @default.
- W3039488799 cites W2274068909 @default.
- W3039488799 cites W2318014300 @default.
- W3039488799 cites W2326527743 @default.
- W3039488799 cites W2344007450 @default.
- W3039488799 cites W2411445504 @default.
- W3039488799 cites W2460897363 @default.
- W3039488799 cites W2572344066 @default.
- W3039488799 cites W2586648405 @default.
- W3039488799 cites W2613842191 @default.
- W3039488799 cites W2617805895 @default.
- W3039488799 cites W2620870153 @default.
- W3039488799 cites W2624096141 @default.
- W3039488799 cites W2706756441 @default.
- W3039488799 cites W2734451746 @default.
- W3039488799 cites W2742558281 @default.
- W3039488799 cites W2789315082 @default.
- W3039488799 cites W2790785565 @default.
- W3039488799 cites W2790888692 @default.
- W3039488799 cites W2794388470 @default.
- W3039488799 cites W2810003284 @default.
- W3039488799 cites W2811182796 @default.
- W3039488799 cites W2891659819 @default.
- W3039488799 cites W2906548750 @default.
- W3039488799 cites W2919102081 @default.
- W3039488799 cites W2921306672 @default.
- W3039488799 cites W2921825971 @default.
- W3039488799 cites W2941222591 @default.
- W3039488799 cites W2942083769 @default.
- W3039488799 cites W2954494198 @default.
- W3039488799 cites W2965602747 @default.
- W3039488799 cites W3006639556 @default.
- W3039488799 cites W3015418032 @default.
- W3039488799 cites W4244477971 @default.
- W3039488799 doi "https://doi.org/10.1093/toxsci/kfaa105" @default.
- W3039488799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7553700" @default.
- W3039488799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32617571" @default.
- W3039488799 hasPublicationYear "2020" @default.
- W3039488799 type Work @default.
- W3039488799 sameAs 3039488799 @default.
- W3039488799 citedByCount "13" @default.
- W3039488799 countsByYear W30394887992021 @default.
- W3039488799 countsByYear W30394887992022 @default.
- W3039488799 countsByYear W30394887992023 @default.
- W3039488799 crossrefType "journal-article" @default.
- W3039488799 hasAuthorship W3039488799A5014582487 @default.
- W3039488799 hasAuthorship W3039488799A5035503566 @default.
- W3039488799 hasAuthorship W3039488799A5045876312 @default.
- W3039488799 hasAuthorship W3039488799A5072815126 @default.
- W3039488799 hasBestOaLocation W30394887992 @default.
- W3039488799 hasConcept C104317684 @default.
- W3039488799 hasConcept C127561419 @default.
- W3039488799 hasConcept C153911025 @default.
- W3039488799 hasConcept C178790620 @default.
- W3039488799 hasConcept C179104552 @default.
- W3039488799 hasConcept C185592680 @default.
- W3039488799 hasConcept C2776151105 @default.
- W3039488799 hasConcept C2778944004 @default.
- W3039488799 hasConcept C2779491297 @default.
- W3039488799 hasConcept C28859421 @default.
- W3039488799 hasConcept C29730261 @default.
- W3039488799 hasConcept C48349386 @default.
- W3039488799 hasConcept C515602321 @default.
- W3039488799 hasConcept C55493867 @default.
- W3039488799 hasConcept C86803240 @default.