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- W3039491166 endingPage "125" @default.
- W3039491166 startingPage "117" @default.
- W3039491166 abstract "Neurodegenerative and neuropsychiatric disorders are pervasive and debilitating conditions characterized by diverse clinical syndromes and comorbidities, whose origins are as complex and heterogeneous as their associated phenotypes. Risk for these disorders involves substantial genetic liability, which has fueled large-scale genetic studies that have led to a flood of discoveries. In turn, these discoveries have exposed substantial gaps in our knowledge with regards to the complicated genetic architecture of each disorder and the substantial amount of genetic overlap among disorders, which implies some degree of shared pathophysiology underlying these clinically distinct, multifactorial disorders. Understanding the role of specific genetic variants will involve resolving the connections between molecular pathways, heterogeneous cell types, specific circuits and disease pathogenesis at the tissue and patient level. We consider the current known genetic basis of these disorders and highlight the utility of molecular systems approaches that establish the function of genetic variation in the context of specific neurobiological networks, cell-types, and life stages. Beyond expanding our knowledge of disease mechanisms, understanding these relationships provides promise for early detection and potential therapeutic interventions." @default.
- W3039491166 created "2020-07-10" @default.
- W3039491166 creator A5018481303 @default.
- W3039491166 creator A5064346542 @default.
- W3039491166 date "2020-12-01" @default.
- W3039491166 modified "2023-10-14" @default.
- W3039491166 title "Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease" @default.
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