Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039515093> ?p ?o ?g. }
- W3039515093 abstract "Summary The HIV-1 envelope (Env) is comprised by mass of over 50% glycans. A goal of HIV-1 vaccine development is the induction of Env glycan-reactive broadly neutralizing antibodies (bnAbs). The 2G12 bnAb recognizes an Env glycan cluster using a unique variable heavy (V H ) domain-swapped conformation that results in fragment antigen-binding (Fab) dimerization. Here we describe Fab-dimerized glycan (FDG)-reactive antibodies without V H -swapped domains from simian-human immunodeficiency virus (SHIV)-infected macaques that neutralized heterologous HIV-1 isolates. FDG precursors were boosted by vaccination in macaques, and were present in HIV-1-naïve humans with an average estimated frequency of one per 340,000 B cells. These data demonstrate frequent HIV-1 Env glycan-reactive bnAb B cell precursors in macaques and humans and reveal a novel strategy for their induction by vaccination. Highlights Discovery of Fab-dimerized HIV-1 glycan-reactive antibodies with a non-domain-swapped architecture Fab-dimerized antibodies neutralize heterologous HIV-1 isolates. Antibodies with this architecture can be elicited by vaccination in macaques. Fab-dimerized antibodies are found in HIV-1 naïve humans." @default.
- W3039515093 created "2020-07-10" @default.
- W3039515093 creator A5000868484 @default.
- W3039515093 creator A5001519257 @default.
- W3039515093 creator A5002763808 @default.
- W3039515093 creator A5004036928 @default.
- W3039515093 creator A5005488553 @default.
- W3039515093 creator A5007210971 @default.
- W3039515093 creator A5008852116 @default.
- W3039515093 creator A5009364817 @default.
- W3039515093 creator A5014091726 @default.
- W3039515093 creator A5017908122 @default.
- W3039515093 creator A5018174312 @default.
- W3039515093 creator A5021207499 @default.
- W3039515093 creator A5023047971 @default.
- W3039515093 creator A5024274180 @default.
- W3039515093 creator A5027270152 @default.
- W3039515093 creator A5028777325 @default.
- W3039515093 creator A5029284176 @default.
- W3039515093 creator A5038092347 @default.
- W3039515093 creator A5039954117 @default.
- W3039515093 creator A5041098204 @default.
- W3039515093 creator A5043677118 @default.
- W3039515093 creator A5045696256 @default.
- W3039515093 creator A5047959968 @default.
- W3039515093 creator A5051827275 @default.
- W3039515093 creator A5053047060 @default.
- W3039515093 creator A5054266472 @default.
- W3039515093 creator A5055818037 @default.
- W3039515093 creator A5056602559 @default.
- W3039515093 creator A5057739482 @default.
- W3039515093 creator A5059058426 @default.
- W3039515093 creator A5059261585 @default.
- W3039515093 creator A5059634158 @default.
- W3039515093 creator A5061200264 @default.
- W3039515093 creator A5065001474 @default.
- W3039515093 creator A5065859286 @default.
- W3039515093 creator A5067541140 @default.
- W3039515093 creator A5073096940 @default.
- W3039515093 creator A5074729687 @default.
- W3039515093 creator A5080175927 @default.
- W3039515093 creator A5084461087 @default.
- W3039515093 creator A5086413052 @default.
- W3039515093 creator A5089898015 @default.
- W3039515093 creator A5090978976 @default.
- W3039515093 date "2020-06-30" @default.
- W3039515093 modified "2023-10-18" @default.
- W3039515093 title "Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques" @default.
- W3039515093 cites W1505517942 @default.
- W3039515093 cites W1555431980 @default.
- W3039515093 cites W1940767994 @default.
- W3039515093 cites W1970749005 @default.
- W3039515093 cites W1972143601 @default.
- W3039515093 cites W1979050735 @default.
- W3039515093 cites W1979366990 @default.
- W3039515093 cites W1980193047 @default.
- W3039515093 cites W1985711808 @default.
- W3039515093 cites W1995466180 @default.
- W3039515093 cites W2000475809 @default.
- W3039515093 cites W2001107896 @default.
- W3039515093 cites W2003298597 @default.
- W3039515093 cites W2007432405 @default.
- W3039515093 cites W2014694459 @default.
- W3039515093 cites W2014764918 @default.
- W3039515093 cites W2026781760 @default.
- W3039515093 cites W2026925153 @default.
- W3039515093 cites W2038883675 @default.
- W3039515093 cites W2047006060 @default.
- W3039515093 cites W2053961916 @default.
- W3039515093 cites W2055448283 @default.
- W3039515093 cites W2069759146 @default.
- W3039515093 cites W2070086938 @default.
- W3039515093 cites W2078437475 @default.
- W3039515093 cites W2083726777 @default.
- W3039515093 cites W2092220359 @default.
- W3039515093 cites W2096409198 @default.
- W3039515093 cites W2097594050 @default.
- W3039515093 cites W2101429257 @default.
- W3039515093 cites W2104234755 @default.
- W3039515093 cites W2108823547 @default.
- W3039515093 cites W2118820599 @default.
- W3039515093 cites W2122210861 @default.
- W3039515093 cites W2122796331 @default.
- W3039515093 cites W2124026197 @default.
- W3039515093 cites W2127130852 @default.
- W3039515093 cites W2127552260 @default.
- W3039515093 cites W2128579789 @default.
- W3039515093 cites W2131760800 @default.
- W3039515093 cites W2132629607 @default.
- W3039515093 cites W2141444589 @default.
- W3039515093 cites W2144733364 @default.
- W3039515093 cites W2149940797 @default.
- W3039515093 cites W2153583705 @default.
- W3039515093 cites W2157107905 @default.
- W3039515093 cites W2157309762 @default.
- W3039515093 cites W2169821755 @default.
- W3039515093 cites W2172063653 @default.
- W3039515093 cites W2172848756 @default.
- W3039515093 cites W2180229411 @default.
- W3039515093 cites W2197610643 @default.