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- W3039523091 abstract "Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging. Several stressors associated with aging and MS pathology, such as oxidative stress, mitochondrial dysfunction, cytokines and replicative exhaustion are known triggers of cellular senescence. Senescent cells exhibit stereotypical metabolic and functional changes, which include cell-cycle arrest and acquiring a pro-inflammatory phenotype secreting cytokines, growth factors, metalloproteinases and reactive oxygen species. They accumulate with aging and can convert neighboring cells to senescence in a paracrine manner. In MS, accelerated cellular senescence may drive disease progression by promoting chronic non-remitting inflammation, loss or altered immune, glial and neuronal function, failure of remyelination, impaired blood-brain barrier integrity and ultimately neurodegeneration. Here we discuss the evidence linking cellular senescence to the pathogenesis of MS and the putative role of senolytic and senomorphic agents as neuroprotective therapies in tackling disease progression." @default.
- W3039523091 created "2020-07-10" @default.
- W3039523091 creator A5015903333 @default.
- W3039523091 creator A5016235730 @default.
- W3039523091 creator A5019481679 @default.
- W3039523091 creator A5047519313 @default.
- W3039523091 creator A5065359762 @default.
- W3039523091 date "2020-06-30" @default.
- W3039523091 modified "2023-10-12" @default.
- W3039523091 title "Aging, Cellular Senescence, and Progressive Multiple Sclerosis" @default.
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