FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039525094> ?p ?o ?g. }

• W3039525094 endingPage "931" @default.
• W3039525094 startingPage "919" @default.
• W3039525094 abstract "Zornia latifolia is a plant suspected to possess psychoactive properties and marketed as a marijuana substitute under the name 'maconha brava'. In this study, the effects of fractions obtained from a 2-propanol extract of aerial portions of the plant were determined by multielectrode array (MEA) analyses on cultured networks of rat cortical neurons. Lipophilic (ZL_lipo, mainly containing flavonoid aglycones), and hydrophilic (ZL_hydro, mainly containing flavonoid glycosides) fractions were initially obtained from the raw extract. ZL_lipo significantly inhibited mean firing rate (MFR) and mean bursting rate (MBR) of MEA recordings, while ZL_hydro induced no inhibition. Column chromatography separation of ZL_lipo yielded five fractions (ZL1-ZL5), among which ZL1 induced the strongest MFR and MBR inhibition. NMR and HPLC-MS analyses of ZL1 revealed the prevalence of the common flavonoids genistein (1) and apigenin (2) (in about a 1:1 ratio), and the presence of the rare flavone syzalterin (6,8-dimethylapigenin) (3) as a minor compound. Exposures of MEA to apigenin and genistein standards did not induce the MFR and MBR inhibition observed with ZL1, whereas exposure to syzalterin standard or to a 1:9 mixture syzalterin-genistein induced effects similar to ZL1. These inhibitory effects were comparable to that observed with high-THC hashish, possibly accounting for the plant psychoactive properties. Data indicate that Z. latifolia, currently marketed as a free herbal product, should be subjected to measures of control. In addition, syzalterin showed distinctive pharmacological properties, opening the way to its possible exploitation as a neuroactive drug." @default.
• W3039525094 created "2020-07-10" @default.
• W3039525094 creator A5002329381 @default.
• W3039525094 creator A5003413472 @default.
• W3039525094 creator A5006744931 @default.
• W3039525094 creator A5026338430 @default.
• W3039525094 creator A5038559219 @default.
• W3039525094 creator A5047823589 @default.
• W3039525094 creator A5049721221 @default.
• W3039525094 creator A5061022967 @default.
• W3039525094 creator A5075992126 @default.
• W3039525094 date "2020-07-06" @default.
• W3039525094 modified "2023-10-01" @default.
• W3039525094 title "Cannabis-like activity of Zornia latifolia Sm. detected in vitro on rat cortical neurons: major role of the flavone syzalterin" @default.
• W3039525094 cites W1542102949 @default.
• W3039525094 cites W1565303318 @default.
• W3039525094 cites W1611868769 @default.
• W3039525094 cites W1916942032 @default.
• W3039525094 cites W1975813031 @default.
• W3039525094 cites W1980002605 @default.
• W3039525094 cites W1987590478 @default.
• W3039525094 cites W1989552647 @default.
• W3039525094 cites W1992700289 @default.
• W3039525094 cites W2001217013 @default.
• W3039525094 cites W2002249313 @default.
• W3039525094 cites W2006538429 @default.
• W3039525094 cites W2010288352 @default.
• W3039525094 cites W2029607252 @default.
• W3039525094 cites W2031866242 @default.
• W3039525094 cites W2042493641 @default.
• W3039525094 cites W2045260260 @default.
• W3039525094 cites W2049970571 @default.
• W3039525094 cites W2053984364 @default.
• W3039525094 cites W2062862729 @default.
• W3039525094 cites W2066141760 @default.
• W3039525094 cites W2072791486 @default.
• W3039525094 cites W2083942952 @default.
• W3039525094 cites W2104048193 @default.
• W3039525094 cites W2105295666 @default.
• W3039525094 cites W2138076373 @default.
• W3039525094 cites W2141449020 @default.
• W3039525094 cites W2165487404 @default.
• W3039525094 cites W2332303179 @default.
• W3039525094 cites W2374660525 @default.
• W3039525094 cites W2407092072 @default.
• W3039525094 cites W2417142388 @default.
• W3039525094 cites W2515262002 @default.
• W3039525094 cites W2609968886 @default.
• W3039525094 cites W2739748386 @default.
• W3039525094 cites W2767420079 @default.
• W3039525094 cites W2772965988 @default.
• W3039525094 cites W2784460514 @default.
• W3039525094 cites W2895838347 @default.
• W3039525094 cites W4242912487 @default.
• W3039525094 doi "https://doi.org/10.1080/01480545.2020.1788057" @default.
• W3039525094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32628037" @default.
• W3039525094 hasPublicationYear "2020" @default.
• W3039525094 type Work @default.
• W3039525094 sameAs 3039525094 @default.
• W3039525094 citedByCount "1" @default.
• W3039525094 countsByYear W30395250942023 @default.
• W3039525094 crossrefType "journal-article" @default.
• W3039525094 hasAuthorship W3039525094A5002329381 @default.
• W3039525094 hasAuthorship W3039525094A5003413472 @default.
• W3039525094 hasAuthorship W3039525094A5006744931 @default.
• W3039525094 hasAuthorship W3039525094A5026338430 @default.
• W3039525094 hasAuthorship W3039525094A5038559219 @default.
• W3039525094 hasAuthorship W3039525094A5047823589 @default.
• W3039525094 hasAuthorship W3039525094A5049721221 @default.
• W3039525094 hasAuthorship W3039525094A5061022967 @default.
• W3039525094 hasAuthorship W3039525094A5075992126 @default.
• W3039525094 hasConcept C134018914 @default.
• W3039525094 hasConcept C179998833 @default.
• W3039525094 hasConcept C185592680 @default.
• W3039525094 hasConcept C194671627 @default.
• W3039525094 hasConcept C202751555 @default.
• W3039525094 hasConcept C2778004101 @default.
• W3039525094 hasConcept C2778298627 @default.
• W3039525094 hasConcept C2778609962 @default.
• W3039525094 hasConcept C2779054382 @default.
• W3039525094 hasConcept C43617362 @default.
• W3039525094 hasConcept C55493867 @default.
• W3039525094 hasConcept C556039675 @default.
• W3039525094 hasConcept C71240020 @default.
• W3039525094 hasConcept C71924100 @default.
• W3039525094 hasConcept C86803240 @default.
• W3039525094 hasConcept C98274493 @default.
• W3039525094 hasConceptScore W3039525094C134018914 @default.
• W3039525094 hasConceptScore W3039525094C179998833 @default.
• W3039525094 hasConceptScore W3039525094C185592680 @default.
• W3039525094 hasConceptScore W3039525094C194671627 @default.
• W3039525094 hasConceptScore W3039525094C202751555 @default.
• W3039525094 hasConceptScore W3039525094C2778004101 @default.
• W3039525094 hasConceptScore W3039525094C2778298627 @default.
• W3039525094 hasConceptScore W3039525094C2778609962 @default.
• W3039525094 hasConceptScore W3039525094C2779054382 @default.
• W3039525094 hasConceptScore W3039525094C43617362 @default.
• W3039525094 hasConceptScore W3039525094C55493867 @default.

• next