FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039551103> ?p ?o ?g. }

• W3039551103 abstract "Abstract Apoptosis, or programmed cell death, is a fundamental requirement for life in multicellular organisms, including humans, and a mechanism to maintain homeostasis and prevent unwarranted cellular proliferations such as cancer. An antisense gene in HIV-1 ( Hap ) induces apoptosis in human cells. Apoptotic T cell death following HIV-1 infection leads to a compromised immune system and eventually AIDS (acquired immunodeficiency syndrome). A review of several studies that focused on long-term survivors of HIV-1 reveals that these survivors had deletion-mutations in Hap . A subset of these survivors changed course and experienced CD4+ T cell death and progression to AIDS. These individuals had virus that regained Hap gene sequence that had previously been deleted. Analysis of the changes in the genetic sequences with in vivo progression of the revertant HIV-1 virus allowed identification of a specific region in Hap we are calling MORT. MORT, in Hap RNA forms a primary microRNA-like structure. Potential human mRNAs targeted by MORT mi/siRNAs include gene/RNA sequences of X-linked inhibitor of apoptosis (XIAP), survivin, and apollon, along with many other human gene sites/RNAs. Thus MORT may be acting as an RNA antagonist to cellular IAPs thereby inducing apoptotic cell death. Surprisingly, additional potential MORT targets include viral sites in human SARS-CoV-2, including the protease, nsp5 RNA. Future uses for RNA therapy and a hypothesis for an HIV intrinsic mechanism utilizing MORT for viral anti-viral (or anti-microbial) and HIV anti-immune cell defense are proposed." @default.
• W3039551103 created "2020-07-10" @default.
• W3039551103 creator A5026307344 @default.
• W3039551103 creator A5033571053 @default.
• W3039551103 date "2020-07-01" @default.
• W3039551103 modified "2023-09-26" @default.
• W3039551103 title "MORT, a locus for apoptosis in the human immunodeficiency virus-type 1 antisense gene: implications for AIDS, Cancer, and Covid-19" @default.
• W3039551103 cites W1085669341 @default.
• W3039551103 cites W1514840588 @default.
• W3039551103 cites W1535874622 @default.
• W3039551103 cites W1558864286 @default.
• W3039551103 cites W1593416572 @default.
• W3039551103 cites W1764550320 @default.
• W3039551103 cites W1961949729 @default.
• W3039551103 cites W1969963419 @default.
• W3039551103 cites W1970165130 @default.
• W3039551103 cites W1971057735 @default.
• W3039551103 cites W1974393084 @default.
• W3039551103 cites W1974729150 @default.
• W3039551103 cites W1976322247 @default.
• W3039551103 cites W1978210201 @default.
• W3039551103 cites W1980269624 @default.
• W3039551103 cites W1985050346 @default.
• W3039551103 cites W1985974546 @default.
• W3039551103 cites W1995513136 @default.
• W3039551103 cites W1997251774 @default.
• W3039551103 cites W2005090326 @default.
• W3039551103 cites W2007021820 @default.
• W3039551103 cites W2014199817 @default.
• W3039551103 cites W2016723478 @default.
• W3039551103 cites W2023285589 @default.
• W3039551103 cites W2027734327 @default.
• W3039551103 cites W2034269086 @default.
• W3039551103 cites W2035523654 @default.
• W3039551103 cites W2052853635 @default.
• W3039551103 cites W2055313665 @default.
• W3039551103 cites W2055349083 @default.
• W3039551103 cites W2064497822 @default.
• W3039551103 cites W2064557078 @default.
• W3039551103 cites W2065133594 @default.
• W3039551103 cites W2074427182 @default.
• W3039551103 cites W2078360449 @default.
• W3039551103 cites W2080966262 @default.
• W3039551103 cites W2081452698 @default.
• W3039551103 cites W2084770914 @default.
• W3039551103 cites W2086227770 @default.
• W3039551103 cites W2088493593 @default.
• W3039551103 cites W2090630729 @default.
• W3039551103 cites W2093423926 @default.
• W3039551103 cites W2094101863 @default.
• W3039551103 cites W2100067355 @default.
• W3039551103 cites W2102373531 @default.
• W3039551103 cites W2104459600 @default.
• W3039551103 cites W2104944781 @default.
• W3039551103 cites W2106118201 @default.
• W3039551103 cites W2108573975 @default.
• W3039551103 cites W2109923675 @default.
• W3039551103 cites W2111098905 @default.
• W3039551103 cites W2113869362 @default.
• W3039551103 cites W2114366060 @default.
• W3039551103 cites W2115688236 @default.
• W3039551103 cites W2117149353 @default.
• W3039551103 cites W2117692326 @default.
• W3039551103 cites W2123040915 @default.
• W3039551103 cites W2130993320 @default.
• W3039551103 cites W2131475898 @default.
• W3039551103 cites W2134250297 @default.
• W3039551103 cites W2139907097 @default.
• W3039551103 cites W2141157874 @default.
• W3039551103 cites W2142784929 @default.
• W3039551103 cites W2150395782 @default.
• W3039551103 cites W2152993806 @default.
• W3039551103 cites W2154011163 @default.
• W3039551103 cites W2156904056 @default.
• W3039551103 cites W2157258525 @default.
• W3039551103 cites W2158029570 @default.
• W3039551103 cites W2158201646 @default.
• W3039551103 cites W2158989286 @default.
• W3039551103 cites W2159651971 @default.
• W3039551103 cites W2160519413 @default.
• W3039551103 cites W2162674813 @default.
• W3039551103 cites W2165729635 @default.
• W3039551103 cites W2169619807 @default.
• W3039551103 cites W2317645848 @default.
• W3039551103 cites W2332941954 @default.
• W3039551103 cites W2336069963 @default.
• W3039551103 cites W2342220526 @default.
• W3039551103 cites W2390999917 @default.
• W3039551103 cites W2524642230 @default.
• W3039551103 cites W2528044351 @default.
• W3039551103 cites W2738491178 @default.
• W3039551103 cites W2782696110 @default.
• W3039551103 cites W2792485812 @default.
• W3039551103 cites W2916516961 @default.
• W3039551103 cites W3003464757 @default.
• W3039551103 cites W4229662680 @default.
• W3039551103 cites W4230515018 @default.
• W3039551103 doi "https://doi.org/10.1101/2020.07.01.180828" @default.
• W3039551103 hasPublicationYear "2020" @default.
• W3039551103 type Work @default.

• next