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• W3039567548 startingPage "81" @default.
• W3039567548 abstract "A common genetic variant in the apolipoprotein E (ApoE) gene called E4 was shown to be strongly linked to both sporadic and familial late onset Alzheimer’s disease (AD). Neurochemical evidence obtained in autopsy-confirmed sporadic AD and control cases over the years clearly indicate that the presence of ApoE4 allele in humans directly compromises several neurotransmitters systems in the aging adult brain. These include the cholinergic, noradrenergic, dopaminergic systems, and the vasopressinergic pathways. In recent years, novel genetic markers modulating drugs responsiveness and adverse side-effect profiles have been identified in clinical drug trials and their pharmacogenomic properties were shown to clearly extend beyond the cholinergic system. This chapter will carefully examine the specific role of genetic variants found to affect cholinergic and noncholinergic neurotransmission, as well as the pathophysiological regulators of AD neurobiology." @default.
• W3039567548 created "2020-07-10" @default.
• W3039567548 creator A5009915411 @default.
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• W3039567548 date "2020-01-01" @default.
• W3039567548 modified "2023-10-05" @default.
• W3039567548 title "Pharmacogenomic approaches to the treatment of sporadic Alzheimer’s disease" @default.
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• W3039567548 doi "https://doi.org/10.1016/b978-0-12-813955-4.00006-4" @default.
• W3039567548 hasPublicationYear "2020" @default.
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