Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039576069> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3039576069 endingPage "620" @default.
- W3039576069 startingPage "617" @default.
- W3039576069 abstract "A 7-month-old male infant with severe hemophilia A who received on-demand therapy with recombinant factor VIII (rFVIII) vomited because of acute intracranial bleeding. With rFVIII treatment for suppressing bleeding, there was development of high-titer (≤673 BU/ml) inhibitors. The patient was administered bypassing agents followed by immune tolerance induction therapy (ITI) with 50 U/kg of FVIII thrice weekly. In addition, he was treated with weekly and thrice weekly prophylaxis with 50 U/kg of activated prothrombin complex concentrate (aPCC). Despite ITI and aPCC prophylaxis treatments, it was difficult to control the hemorrhage, and the annualized bleeding ratio (ABR) remained high (5-13 bleeding episodes per year). We started emicizumab 2 weeks after completing the administration of aPCC. Weekly subdermal injections of 1.5 mg/kg emicizumab after loading dramatically decreased ABR (one bleeding episode per year), although biweekly injections of 3 mg/kg emicizumab for several months were associated with one joint hemorrhage. Compared to regular aPCC administration, our observations suggest that weekly emicizumab treatments can improve the ABR in a hemophilia patient with inhibitors and improve the quality of life of patient without limitations in terms of school events." @default.
- W3039576069 created "2020-07-10" @default.
- W3039576069 creator A5000608555 @default.
- W3039576069 creator A5013169655 @default.
- W3039576069 creator A5034646173 @default.
- W3039576069 creator A5054966180 @default.
- W3039576069 date "2020-01-01" @default.
- W3039576069 modified "2023-09-23" @default.
- W3039576069 title "[Successful treatment by switching from activated prothrombin complex concentrate to emicizumab therapy in a hemophilia A patient with inhibitors]." @default.
- W3039576069 doi "https://doi.org/10.11406/rinketsu.61.617" @default.
- W3039576069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32624534" @default.
- W3039576069 hasPublicationYear "2020" @default.
- W3039576069 type Work @default.
- W3039576069 sameAs 3039576069 @default.
- W3039576069 citedByCount "0" @default.
- W3039576069 crossrefType "journal-article" @default.
- W3039576069 hasAuthorship W3039576069A5000608555 @default.
- W3039576069 hasAuthorship W3039576069A5013169655 @default.
- W3039576069 hasAuthorship W3039576069A5034646173 @default.
- W3039576069 hasAuthorship W3039576069A5054966180 @default.
- W3039576069 hasConcept C126322002 @default.
- W3039576069 hasConcept C141071460 @default.
- W3039576069 hasConcept C159654299 @default.
- W3039576069 hasConcept C203014093 @default.
- W3039576069 hasConcept C2776301958 @default.
- W3039576069 hasConcept C2777091921 @default.
- W3039576069 hasConcept C2777902738 @default.
- W3039576069 hasConcept C2778961111 @default.
- W3039576069 hasConcept C2779076696 @default.
- W3039576069 hasConcept C2779161974 @default.
- W3039576069 hasConcept C2908647359 @default.
- W3039576069 hasConcept C2986817661 @default.
- W3039576069 hasConcept C32611913 @default.
- W3039576069 hasConcept C71924100 @default.
- W3039576069 hasConcept C99454951 @default.
- W3039576069 hasConceptScore W3039576069C126322002 @default.
- W3039576069 hasConceptScore W3039576069C141071460 @default.
- W3039576069 hasConceptScore W3039576069C159654299 @default.
- W3039576069 hasConceptScore W3039576069C203014093 @default.
- W3039576069 hasConceptScore W3039576069C2776301958 @default.
- W3039576069 hasConceptScore W3039576069C2777091921 @default.
- W3039576069 hasConceptScore W3039576069C2777902738 @default.
- W3039576069 hasConceptScore W3039576069C2778961111 @default.
- W3039576069 hasConceptScore W3039576069C2779076696 @default.
- W3039576069 hasConceptScore W3039576069C2779161974 @default.
- W3039576069 hasConceptScore W3039576069C2908647359 @default.
- W3039576069 hasConceptScore W3039576069C2986817661 @default.
- W3039576069 hasConceptScore W3039576069C32611913 @default.
- W3039576069 hasConceptScore W3039576069C71924100 @default.
- W3039576069 hasConceptScore W3039576069C99454951 @default.
- W3039576069 hasIssue "6" @default.
- W3039576069 hasLocation W30395760691 @default.
- W3039576069 hasOpenAccess W3039576069 @default.
- W3039576069 hasPrimaryLocation W30395760691 @default.
- W3039576069 hasRelatedWork W2003938723 @default.
- W3039576069 hasRelatedWork W2019517015 @default.
- W3039576069 hasRelatedWork W2118496982 @default.
- W3039576069 hasRelatedWork W2364998975 @default.
- W3039576069 hasRelatedWork W2439875401 @default.
- W3039576069 hasRelatedWork W2793763904 @default.
- W3039576069 hasRelatedWork W3039576069 @default.
- W3039576069 hasRelatedWork W4238867864 @default.
- W3039576069 hasRelatedWork W2519357708 @default.
- W3039576069 hasRelatedWork W2525756941 @default.
- W3039576069 hasVolume "61" @default.
- W3039576069 isParatext "false" @default.
- W3039576069 isRetracted "false" @default.
- W3039576069 magId "3039576069" @default.
- W3039576069 workType "article" @default.