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- W3039576578 endingPage "2282" @default.
- W3039576578 startingPage "2268" @default.
- W3039576578 abstract "Protein aggregation has been widely implicated in neurodegenerative diseases such as Alzheimer's disease, frontotemporal dementia, Parkinson's disease, and Huntington disease, as well as in systemic amyloidoses and conditions associated with localized amyloid deposits, such as type-II diabetes. The pressing need for a better understanding of the factors governing protein assembly has driven research for the development of molecular sensors for amyloidogenic proteins. To date, a number of sensors have been developed that report on the presence of protein aggregates utilizing various modalities, and their utility demonstrated for imaging protein aggregation in vitro and in vivo. Analysis of these sensors highlights the various advantages and disadvantages of the different imaging modalities and makes clear that multimodal sensors with properties amenable to more than one imaging technique need to be developed. This critical review highlights the key molecular scaffolds reported for molecular imaging modalities such as fluorescence, positron emission tomography, single photon emission computed tomography, and magnetic resonance imaging and includes discussion of the advantages and disadvantages of each modality, and future directions for the design of amyloid sensors. We also discuss the recent efforts focused on the design and development of multimodal sensors and the value of cross-validation across multiple modalities." @default.
- W3039576578 created "2020-07-10" @default.
- W3039576578 creator A5025304140 @default.
- W3039576578 creator A5031455448 @default.
- W3039576578 creator A5079596222 @default.
- W3039576578 date "2020-07-06" @default.
- W3039576578 modified "2023-10-01" @default.
- W3039576578 title "Strategies for the Molecular Imaging of Amyloid and the Value of a Multimodal Approach" @default.
- W3039576578 cites W1486032953 @default.
- W3039576578 cites W1559704329 @default.
- W3039576578 cites W1858389955 @default.
- W3039576578 cites W1958023642 @default.
- W3039576578 cites W1964152528 @default.
- W3039576578 cites W1965203878 @default.
- W3039576578 cites W1981556764 @default.
- W3039576578 cites W1985603549 @default.
- W3039576578 cites W1986291736 @default.
- W3039576578 cites W1986905524 @default.
- W3039576578 cites W1989662165 @default.
- W3039576578 cites W1995217052 @default.
- W3039576578 cites W1995713813 @default.
- W3039576578 cites W2000441131 @default.
- W3039576578 cites W2000770097 @default.
- W3039576578 cites W2001385435 @default.
- W3039576578 cites W2001447241 @default.
- W3039576578 cites W2006665405 @default.
- W3039576578 cites W2007284815 @default.
- W3039576578 cites W2015145881 @default.
- W3039576578 cites W2015476325 @default.
- W3039576578 cites W2020515492 @default.
- W3039576578 cites W2021585786 @default.
- W3039576578 cites W2025595434 @default.
- W3039576578 cites W2027442107 @default.
- W3039576578 cites W2028459481 @default.
- W3039576578 cites W2030325989 @default.
- W3039576578 cites W2047623666 @default.
- W3039576578 cites W2050262683 @default.
- W3039576578 cites W2050508852 @default.
- W3039576578 cites W2056237956 @default.
- W3039576578 cites W2065358927 @default.
- W3039576578 cites W2065376967 @default.
- W3039576578 cites W2065505692 @default.
- W3039576578 cites W2069433780 @default.
- W3039576578 cites W2071542271 @default.
- W3039576578 cites W2074274706 @default.
- W3039576578 cites W2076030252 @default.
- W3039576578 cites W2082184462 @default.
- W3039576578 cites W2085899859 @default.
- W3039576578 cites W2090294047 @default.
- W3039576578 cites W2092677917 @default.
- W3039576578 cites W2095049107 @default.
- W3039576578 cites W2098705089 @default.
- W3039576578 cites W2109727228 @default.
- W3039576578 cites W2115735718 @default.
- W3039576578 cites W2116124089 @default.
- W3039576578 cites W2116940063 @default.
- W3039576578 cites W2118010696 @default.
- W3039576578 cites W2120800588 @default.
- W3039576578 cites W2123021161 @default.
- W3039576578 cites W2123444269 @default.
- W3039576578 cites W2124172940 @default.
- W3039576578 cites W2124544960 @default.
- W3039576578 cites W2127642254 @default.
- W3039576578 cites W2130393399 @default.
- W3039576578 cites W2137792756 @default.
- W3039576578 cites W2138023380 @default.
- W3039576578 cites W2140797607 @default.
- W3039576578 cites W2144512165 @default.
- W3039576578 cites W2144535585 @default.
- W3039576578 cites W2144975288 @default.
- W3039576578 cites W2155258338 @default.
- W3039576578 cites W2159879659 @default.
- W3039576578 cites W2163201296 @default.
- W3039576578 cites W2163372429 @default.
- W3039576578 cites W2164909639 @default.
- W3039576578 cites W2186953769 @default.
- W3039576578 cites W2194293559 @default.
- W3039576578 cites W2198850752 @default.
- W3039576578 cites W2225657959 @default.
- W3039576578 cites W2259672753 @default.
- W3039576578 cites W2307600746 @default.
- W3039576578 cites W2317113760 @default.
- W3039576578 cites W2327665479 @default.
- W3039576578 cites W2328607238 @default.
- W3039576578 cites W2330490280 @default.
- W3039576578 cites W2333446478 @default.
- W3039576578 cites W2341395354 @default.
- W3039576578 cites W2382261180 @default.
- W3039576578 cites W2401885309 @default.
- W3039576578 cites W2412145118 @default.
- W3039576578 cites W2526931426 @default.
- W3039576578 cites W2550424027 @default.
- W3039576578 cites W2560511804 @default.
- W3039576578 cites W2572424493 @default.
- W3039576578 cites W2606393075 @default.
- W3039576578 cites W2614053601 @default.
- W3039576578 cites W2664576861 @default.
- W3039576578 cites W2734651019 @default.