Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039592711> ?p ?o ?g. }
- W3039592711 abstract "Abstract Abnormal coagulation and an increased risk of thrombosis are features of severe COVID-19, with parallels proposed with hemophagocytic lymphohistiocytosis (HLH), a life-threating condition associated with hyperinflammation. The presence of HLH was described in severely ill patients during the H1N1 influenza epidemic, presenting with pulmonary vascular thrombosis. We tested the hypothesis that genes causing primary HLH regulate pathways linking pulmonary thromboembolism to the presence of SARS-CoV-2 using novel network-informed computational algorithms. This approach led to the identification of Neutrophils Extracellular Traps (NETs) as plausible mediators of vascular thrombosis in severe COVID-19 in children and adults. Taken together, the network-informed analysis led us to propose the following model: the release of NETs in response to inflammatory signals acting in concert with SARS-CoV-2 damage the endothelium and direct platelet-activation promoting abnormal coagulation leading to serious complications of COVID-19. The underlying hypothesis is that genetic and/or environmental conditions that favor the release of NETs may predispose individuals to thrombotic complications of COVID-19 due to an increase risk of abnormal coagulation. This would be a common pathogenic mechanism in conditions including autoimmune/infectious diseases, hematologic and metabolic disorders." @default.
- W3039592711 created "2020-07-10" @default.
- W3039592711 creator A5003509226 @default.
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- W3039592711 creator A5084971879 @default.
- W3039592711 date "2020-07-02" @default.
- W3039592711 modified "2023-10-03" @default.
- W3039592711 title "A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil Extracellular Traps as mediators of thrombosis in COVID-19" @default.
- W3039592711 cites W1578965592 @default.
- W3039592711 cites W1911952 @default.
- W3039592711 cites W1948224020 @default.
- W3039592711 cites W1978982003 @default.
- W3039592711 cites W2007626593 @default.
- W3039592711 cites W2011340259 @default.
- W3039592711 cites W2012437303 @default.
- W3039592711 cites W2015370938 @default.
- W3039592711 cites W2018843223 @default.
- W3039592711 cites W2021796120 @default.
- W3039592711 cites W2032894750 @default.
- W3039592711 cites W2041026060 @default.
- W3039592711 cites W2058192001 @default.
- W3039592711 cites W2061053728 @default.
- W3039592711 cites W2067986808 @default.
- W3039592711 cites W2071978209 @default.
- W3039592711 cites W2074274231 @default.
- W3039592711 cites W2098261445 @default.
- W3039592711 cites W2098485024 @default.
- W3039592711 cites W2098613848 @default.
- W3039592711 cites W2111604419 @default.
- W3039592711 cites W2140995313 @default.
- W3039592711 cites W2153581012 @default.
- W3039592711 cites W2163067702 @default.
- W3039592711 cites W2169535061 @default.
- W3039592711 cites W2171730321 @default.
- W3039592711 cites W2310456000 @default.
- W3039592711 cites W2327736479 @default.
- W3039592711 cites W2417595397 @default.
- W3039592711 cites W2547632055 @default.
- W3039592711 cites W2593144838 @default.
- W3039592711 cites W2626760894 @default.
- W3039592711 cites W2762816177 @default.
- W3039592711 cites W2783439885 @default.
- W3039592711 cites W2796883066 @default.
- W3039592711 cites W2798105113 @default.
- W3039592711 cites W2807619077 @default.
- W3039592711 cites W2885977543 @default.
- W3039592711 cites W2888492249 @default.
- W3039592711 cites W2898080189 @default.
- W3039592711 cites W2899728356 @default.
- W3039592711 cites W2900569176 @default.
- W3039592711 cites W2901233119 @default.
- W3039592711 cites W2904625821 @default.
- W3039592711 cites W2914519030 @default.
- W3039592711 cites W2918844264 @default.
- W3039592711 cites W2941779923 @default.
- W3039592711 cites W2942444134 @default.
- W3039592711 cites W2947642275 @default.
- W3039592711 cites W2950439755 @default.
- W3039592711 cites W2954560205 @default.
- W3039592711 cites W2967469077 @default.
- W3039592711 cites W2969128576 @default.
- W3039592711 cites W2995120640 @default.
- W3039592711 cites W3000361975 @default.
- W3039592711 cites W3002405437 @default.
- W3039592711 cites W3008461878 @default.
- W3039592711 cites W3009314935 @default.
- W3039592711 cites W3012421327 @default.
- W3039592711 cites W3012502392 @default.
- W3039592711 cites W3013233995 @default.
- W3039592711 cites W3013749134 @default.
- W3039592711 cites W3014206579 @default.
- W3039592711 cites W3016123694 @default.
- W3039592711 cites W3016489853 @default.
- W3039592711 cites W3017806808 @default.
- W3039592711 cites W3018507926 @default.
- W3039592711 cites W3020735691 @default.
- W3039592711 cites W3021684016 @default.
- W3039592711 cites W3022248657 @default.
- W3039592711 cites W3022285953 @default.
- W3039592711 cites W3022564719 @default.
- W3039592711 cites W3024521558 @default.
- W3039592711 cites W3024913291 @default.
- W3039592711 cites W3025256562 @default.
- W3039592711 cites W3025458834 @default.
- W3039592711 cites W3026306769 @default.
- W3039592711 cites W3027918021 @default.
- W3039592711 cites W3029289629 @default.
- W3039592711 cites W3124375039 @default.
- W3039592711 cites W4232931847 @default.
- W3039592711 cites W4241263512 @default.