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• W3039593810 abstract "Abstract BACKGROUND CONTEXT The interface and interactions between an interbody cage, graft material, and host bone can all participate in the fusion. Shortcomings of Poly(aryl-ether-ether-ketone) interbody cages have been addressed with novel titanium surfaces. Titanium surfaces paired with macroscale topography features on the endplates and within the aperture may provide additional benefits. PURPOSE To evaluate the influence of cage design parameters on interbody fusion in a large animal preclinical model. STUDY DESIGN/SETTING A comparative preclinical large animal model was performed to evaluate how macroscale topography features of an interbody cage can facilitate early integration between the host bone, graft material, and interbody cage and these effects on biomechanical stability and fusion. METHODS Forty single level interbody fusions (L4–L5) using iliac crest autograft and bilateral pedicle screw fixation were performed in adult sheep to evaluate the effect of undercut macrostructure topography features of an interbody cage on the endplates and within the aperture. Fusions were evaluated at 6 and 12 weeks (n=10 per group) using radiography, microcomputed tomography, biomechanical integrity, and histology endpoints. RESULTS The presence of the undercut macrostructures present on the endplates and within the aperture statistically improved biomechanical integrity at 6 and 12 weeks compared with controls. Microcomputed tomography and histology demonstrated bony interdigitation within the endplate and aperture features contributing to the improvement in properties. CONCLUSIONS The present study demonstrates that Poly(aryl-ether-ether-ketone) implants with titanium surfaces can be augmented by undercut macrostructures present on the endplates and within the aperture to provide opportunities for a series of anchoring points that, with new bone formation and remodelling, result in earlier and improved biomechanical integrity of the treated level. CLINICAL SIGNIFICANCE This preclinical study showed that bone interdigitation with the undercut macrostructures present on the endplates and within the aperture resulted in improved fusion and biomechanical stability in a clinically relevant spinal fusion model. Future clinical study is warranted to evaluate such implants’ performance in humans." @default.
• W3039593810 created "2020-07-10" @default.
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• W3039593810 date "2020-11-01" @default.
• W3039593810 modified "2023-10-14" @default.
• W3039593810 title "Undercut macrostructure topography on and within an interbody cage improves biomechanical stability and interbody fusion" @default.
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• W3039593810 doi "https://doi.org/10.1016/j.spinee.2020.06.023" @default.
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