FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3039643179> ?p ?o ?g. }

• W3039643179 abstract "Insulin and insulin-like growth factor-1 (IGF1), acting respectively via the insulin (INSR) and IGF1 (IGF1R) receptors, play key developmental and metabolic roles throughout life. In addition, both signaling pathways fulfill important roles in cancer initiation and progression. The inherent complexity of the INSR/IGF1R pathways, along with the well documented cross-talk between insulin-like ligands and receptors, translated into a disappointingly slow pace in the development of INSR/IGF1R-directed therapies in oncology. The present study was aimed at identifying mechanistic differences between INSR and IGF1R using a recently developed bioinformatics tool, the Biological Network Simulator (BioNSi). This application allows to import and merge multiple pathways and interaction information from the KEGG database into a single network representation. The BioNsi network simulation tool allowed us to exploit the availability of gene expression data derived from breast cancer cell lines with specific disruptions of the INSR or IGF1R genes in order to investigate potential differences in protein expression that might be linked to biological attributes of the specific receptor networks. Modeling-generated information was corroborated by experimental and biological assays. Our simulation analysis identified a number of commonalities and, most importantly, dissimilarities between the IGF1R and INSR pathways that were experimentally validated and that might help explain the basis for the biological differences between these networks." @default.
• W3039643179 created "2020-07-10" @default.
• W3039643179 creator A5003904670 @default.
• W3039643179 creator A5024749019 @default.
• W3039643179 creator A5037650844 @default.
• W3039643179 creator A5050551541 @default.
• W3039643179 creator A5085482230 @default.
• W3039643179 date "2020-07-07" @default.
• W3039643179 modified "2023-10-16" @default.
• W3039643179 title "Systems Analysis of Insulin and IGF1 Receptors Networks in Breast Cancer Cells Identifies Commonalities and Divergences in Expression Patterns" @default.
• W3039643179 cites W1822043635 @default.
• W3039643179 cites W1966738468 @default.
• W3039643179 cites W1969536729 @default.
• W3039643179 cites W1970332601 @default.
• W3039643179 cites W1970563875 @default.
• W3039643179 cites W1974196575 @default.
• W3039643179 cites W1987544117 @default.
• W3039643179 cites W2006485431 @default.
• W3039643179 cites W2007278291 @default.
• W3039643179 cites W2008947700 @default.
• W3039643179 cites W2023771726 @default.
• W3039643179 cites W2031997272 @default.
• W3039643179 cites W2044714476 @default.
• W3039643179 cites W2047683380 @default.
• W3039643179 cites W2052722944 @default.
• W3039643179 cites W2053785710 @default.
• W3039643179 cites W2067233601 @default.
• W3039643179 cites W2075931967 @default.
• W3039643179 cites W2077180087 @default.
• W3039643179 cites W2081729700 @default.
• W3039643179 cites W2084967524 @default.
• W3039643179 cites W2088861488 @default.
• W3039643179 cites W2089171551 @default.
• W3039643179 cites W2096452837 @default.
• W3039643179 cites W2104908670 @default.
• W3039643179 cites W2119994212 @default.
• W3039643179 cites W2129013371 @default.
• W3039643179 cites W2131058993 @default.
• W3039643179 cites W2136493937 @default.
• W3039643179 cites W2137395664 @default.
• W3039643179 cites W2137560695 @default.
• W3039643179 cites W2148829631 @default.
• W3039643179 cites W2152185756 @default.
• W3039643179 cites W2163480486 @default.
• W3039643179 cites W2164237749 @default.
• W3039643179 cites W2424236546 @default.
• W3039643179 cites W2465162209 @default.
• W3039643179 cites W2518219781 @default.
• W3039643179 cites W2559588208 @default.
• W3039643179 cites W2584289628 @default.
• W3039643179 cites W2749412384 @default.
• W3039643179 cites W2763635492 @default.
• W3039643179 cites W2788776849 @default.
• W3039643179 cites W2912063221 @default.
• W3039643179 cites W2968300883 @default.
• W3039643179 cites W4250323908 @default.
• W3039643179 cites W4251606449 @default.
• W3039643179 cites W733633 @default.
• W3039643179 doi "https://doi.org/10.3389/fendo.2020.00435" @default.
• W3039643179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7359857" @default.
• W3039643179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32733384" @default.
• W3039643179 hasPublicationYear "2020" @default.
• W3039643179 type Work @default.
• W3039643179 sameAs 3039643179 @default.
• W3039643179 citedByCount "2" @default.
• W3039643179 countsByYear W30396431792022 @default.
• W3039643179 crossrefType "journal-article" @default.
• W3039643179 hasAuthorship W3039643179A5003904670 @default.
• W3039643179 hasAuthorship W3039643179A5024749019 @default.
• W3039643179 hasAuthorship W3039643179A5037650844 @default.
• W3039643179 hasAuthorship W3039643179A5050551541 @default.
• W3039643179 hasAuthorship W3039643179A5085482230 @default.
• W3039643179 hasBestOaLocation W30396431791 @default.
• W3039643179 hasConcept C112446052 @default.
• W3039643179 hasConcept C121608353 @default.
• W3039643179 hasConcept C134018914 @default.
• W3039643179 hasConcept C144174609 @default.
• W3039643179 hasConcept C152662350 @default.
• W3039643179 hasConcept C170493617 @default.
• W3039643179 hasConcept C2775960820 @default.
• W3039643179 hasConcept C2777391703 @default.
• W3039643179 hasConcept C2779306644 @default.
• W3039643179 hasConcept C2780689927 @default.
• W3039643179 hasConcept C28225019 @default.
• W3039643179 hasConcept C41008148 @default.
• W3039643179 hasConcept C530470458 @default.
• W3039643179 hasConcept C54355233 @default.
• W3039643179 hasConcept C60644358 @default.
• W3039643179 hasConcept C62478195 @default.
• W3039643179 hasConcept C70721500 @default.
• W3039643179 hasConcept C86803240 @default.
• W3039643179 hasConcept C95444343 @default.
• W3039643179 hasConceptScore W3039643179C112446052 @default.
• W3039643179 hasConceptScore W3039643179C121608353 @default.
• W3039643179 hasConceptScore W3039643179C134018914 @default.
• W3039643179 hasConceptScore W3039643179C144174609 @default.
• W3039643179 hasConceptScore W3039643179C152662350 @default.
• W3039643179 hasConceptScore W3039643179C170493617 @default.
• W3039643179 hasConceptScore W3039643179C2775960820 @default.
• W3039643179 hasConceptScore W3039643179C2777391703 @default.

• next