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- W3039656498 abstract "Coronavirus disease 2019 (COVID-19) first emerged in late 2019 in China. At the time of writing, its causative agent SARS-CoV-2 has spread worldwide infecting over 9 million individuals and causing more than 460,000 deaths. In the absence of vaccines, we are facing the dramatic challenge of controlling COVID-19 pandemic. Among currently available drugs, type I Interferons (IFN-I) – mainly IFN-α and β –represent ideal candidates given their direct and immune-mediated antiviral effects and the long record of clinical use. However, the best modalities of using these cytokines in SARS-CoV-2 infected patients is a matter of debate. Here, we discuss how we can exploit the current knowledge on IFN-I system to tailor the most promising dosing, timing and route of administration of IFN-I to the disease stage, with the final aim of making these cytokines a valuable therapeutic strategy in today's fight against COVID-19 pandemic." @default.
- W3039656498 created "2020-07-10" @default.
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- W3039656498 date "2020-08-01" @default.
- W3039656498 modified "2023-10-04" @default.
- W3039656498 title "Are we fully exploiting type I Interferons in today's fight against COVID-19 pandemic?" @default.
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- W3039656498 doi "https://doi.org/10.1016/j.cytogfr.2020.07.010" @default.
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